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Antibodies to the Ganglioside GD1b in a Patient With Motor Neuron Disease and Thyroid Adenoma

Antibodies to the Ganglioside GD1b in a Patient With Motor Neuron Disease and Thyroid Adenoma Abstract • Patients with motor neuron disease with thyroid disorders have been described, although the relationship between the two conditions is unclear. We treated a patient with amyotrophic lateral sclerosis who also had a follicular adenoma of the thyroid gland. Because thyroid gland plasma membranes contain high concentrations of complex gangliosides, such as GD1b, and some patients with motor neuron disease have IgM antibodies to GD1b, we decided to assay serum from this patient for the presence of antiganglioside antibodies. IgM antibodies to GD1b were detectable at serum dilutions of 1:500 and 1:1000 by enzyme-linked immunosorbent assay. While these titers are less than those usually described in patients with plasma cell dyscrasia, they are well in excess of normal values. Antibody to GM1 was also detectable at a lower (1:100) dilution. We do not know the importance of the anti-GD1b antibodies in this patient, but it is possible that antibodies to GD1b are involved in this and other cases of motor neuron disease associated with thyroid disease. References 1. Appel SH. Stockton-Appel V, Stewart SS, Kerman RH. Amyotrophic lateral sclerosis: associated clinical disorders and immunological evaluations . Arch Neurol . 1987;43:234-238.Crossref 2. Garcia LA, Fleming RH. Reversible corticospinal tract disease due to hyperthyroidism . Arch Neurol . 1977;34:647-648.Crossref 3. McMenamin J, Croxson M. Motor neuron disease and hyperthyroid Graves's disease: a chance association . J Neurol Neurosurg Psychiatry . 1980;43:46-49.Crossref 4. Shy ME, Evans VA, Lublin FD, et al. Antibodies to GM1 and GD1b in patients with motor neuron disease with plasma cell dyscrasia . Ann Neurol . 1989;25:511-513.Crossref 5. Shy ME, Heiman-Patterson T, Parry G, et al. Lower motor neuron disease in a patient with autoantibodies against gangliosides GM1 and GD1b; improvement following immunotherapy . Neurology . 1990;40:842-844.Crossref 6. Freddo L, Yu RK, Latov N, et al. Gangliosides GM1 and GD1b are antigens for IgM M-protein in a patient with motor neuron disease . Neurology . 1986;36:454-458.Crossref 7. Schluep M, Steck AJ. Immunostaining of motor nerve terminals by IgM M protein with activity against gangliosides GM1 and GD1b from a patient with motor neuron disease . Neurology . 1988;38:1890-1892.Crossref 8. Pestronk A, Adams RN, Clawson L, et al. Serum antibodies to GM1 ganglioside in ALS . Neurology . 1988;38:1457-1461.Crossref 9. Pestronk A, Cornblath DR, Ilyas AA, et al. A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside . Ann Neurol . 1988;24:73-78.Crossref 10. Latov N, Hays AP, Donofrio PD, et al. Monoclonal IgM with unique specificity for gangliosides GM1 and GD1b and to lacto-N-tetraose associated with human motor neuron disease . Neurology . 1988;38:763-768.Crossref 11. Published erratum appears in Neurology 1988;38:1506. 12. Fishman PS, Carrigan DR. Motoneuron uptake from the circulation of the binding fragment of tetanus toxin . Arch Neurol . 1988;45:558-561.Crossref 13. Habermann E. Distribution of tetanus toxin in rats with generalized tetanus as influenced by antitoxin. Naunyn Schmeidebergs . Arch Pharmacol . 1973;276:327-340.Crossref 14. Mellanby J. How does tetanus toxin act? Neuroscience . 1981;6:281-300.Crossref 15. Ledley F, Lee G, Kohn LD, Habig WH, Hardegree MC. Tetanus toxin interactions with thyroid plasma membranes . J Biol Chem . 1977;252:4049-4055. 16. Lee G, Grollman EF, Dyer S, et al. Tetanus toxin and thyrotropin interactions with rat membrane preparations . J Biol Chem . 1979;254:3826-3832. 17. Baroni CD, Manente L, Maccallini V, DiMatteo G. Primary malignant tumors of the thyroid gland: histology, age, and sex distribution and pathological correlation in 139 cases . Tumori . 1983;69:205-213. 18. Lo Gerfo P, Starker P, Weber C, Moore D. Incidence of cancer in surgically treated thyroid nodules based on method of selection . Surgery . 1985;96:1197-1201. 19. Ron E, Modan B. Thyroid . In: Schoffenfeld D, Fraumeni JF, eds. Cancer Epidemiology and Prevention . Philadelphia, Pa: WB Saunders Co; 1982:837-347. 20. Evans BK, Fagan C, Arnold T, Dropcho EJ, Oh SJ. Paraneoplastic motor neuron disease and renal cell carcinoma: improvement after nephrectomy . Neurology . 1990;40:960-962.Crossref 21. Anderson NE, Rosenblum MK, Posner JB. Paraneoplastic cerebellar degeneration: clinical-immunological correlations . Ann Neurol . 1988;24:559-567.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Antibodies to the Ganglioside GD1b in a Patient With Motor Neuron Disease and Thyroid Adenoma

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Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1991.00530230096030
Publisher site
See Article on Publisher Site

Abstract

Abstract • Patients with motor neuron disease with thyroid disorders have been described, although the relationship between the two conditions is unclear. We treated a patient with amyotrophic lateral sclerosis who also had a follicular adenoma of the thyroid gland. Because thyroid gland plasma membranes contain high concentrations of complex gangliosides, such as GD1b, and some patients with motor neuron disease have IgM antibodies to GD1b, we decided to assay serum from this patient for the presence of antiganglioside antibodies. IgM antibodies to GD1b were detectable at serum dilutions of 1:500 and 1:1000 by enzyme-linked immunosorbent assay. While these titers are less than those usually described in patients with plasma cell dyscrasia, they are well in excess of normal values. Antibody to GM1 was also detectable at a lower (1:100) dilution. We do not know the importance of the anti-GD1b antibodies in this patient, but it is possible that antibodies to GD1b are involved in this and other cases of motor neuron disease associated with thyroid disease. References 1. Appel SH. Stockton-Appel V, Stewart SS, Kerman RH. Amyotrophic lateral sclerosis: associated clinical disorders and immunological evaluations . Arch Neurol . 1987;43:234-238.Crossref 2. Garcia LA, Fleming RH. Reversible corticospinal tract disease due to hyperthyroidism . Arch Neurol . 1977;34:647-648.Crossref 3. McMenamin J, Croxson M. Motor neuron disease and hyperthyroid Graves's disease: a chance association . J Neurol Neurosurg Psychiatry . 1980;43:46-49.Crossref 4. Shy ME, Evans VA, Lublin FD, et al. Antibodies to GM1 and GD1b in patients with motor neuron disease with plasma cell dyscrasia . Ann Neurol . 1989;25:511-513.Crossref 5. Shy ME, Heiman-Patterson T, Parry G, et al. Lower motor neuron disease in a patient with autoantibodies against gangliosides GM1 and GD1b; improvement following immunotherapy . Neurology . 1990;40:842-844.Crossref 6. Freddo L, Yu RK, Latov N, et al. Gangliosides GM1 and GD1b are antigens for IgM M-protein in a patient with motor neuron disease . Neurology . 1986;36:454-458.Crossref 7. Schluep M, Steck AJ. Immunostaining of motor nerve terminals by IgM M protein with activity against gangliosides GM1 and GD1b from a patient with motor neuron disease . Neurology . 1988;38:1890-1892.Crossref 8. Pestronk A, Adams RN, Clawson L, et al. Serum antibodies to GM1 ganglioside in ALS . Neurology . 1988;38:1457-1461.Crossref 9. Pestronk A, Cornblath DR, Ilyas AA, et al. A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside . Ann Neurol . 1988;24:73-78.Crossref 10. Latov N, Hays AP, Donofrio PD, et al. Monoclonal IgM with unique specificity for gangliosides GM1 and GD1b and to lacto-N-tetraose associated with human motor neuron disease . Neurology . 1988;38:763-768.Crossref 11. Published erratum appears in Neurology 1988;38:1506. 12. Fishman PS, Carrigan DR. Motoneuron uptake from the circulation of the binding fragment of tetanus toxin . Arch Neurol . 1988;45:558-561.Crossref 13. Habermann E. Distribution of tetanus toxin in rats with generalized tetanus as influenced by antitoxin. Naunyn Schmeidebergs . Arch Pharmacol . 1973;276:327-340.Crossref 14. Mellanby J. How does tetanus toxin act? Neuroscience . 1981;6:281-300.Crossref 15. Ledley F, Lee G, Kohn LD, Habig WH, Hardegree MC. Tetanus toxin interactions with thyroid plasma membranes . J Biol Chem . 1977;252:4049-4055. 16. Lee G, Grollman EF, Dyer S, et al. Tetanus toxin and thyrotropin interactions with rat membrane preparations . J Biol Chem . 1979;254:3826-3832. 17. Baroni CD, Manente L, Maccallini V, DiMatteo G. Primary malignant tumors of the thyroid gland: histology, age, and sex distribution and pathological correlation in 139 cases . Tumori . 1983;69:205-213. 18. Lo Gerfo P, Starker P, Weber C, Moore D. Incidence of cancer in surgically treated thyroid nodules based on method of selection . Surgery . 1985;96:1197-1201. 19. Ron E, Modan B. Thyroid . In: Schoffenfeld D, Fraumeni JF, eds. Cancer Epidemiology and Prevention . Philadelphia, Pa: WB Saunders Co; 1982:837-347. 20. Evans BK, Fagan C, Arnold T, Dropcho EJ, Oh SJ. Paraneoplastic motor neuron disease and renal cell carcinoma: improvement after nephrectomy . Neurology . 1990;40:960-962.Crossref 21. Anderson NE, Rosenblum MK, Posner JB. Paraneoplastic cerebellar degeneration: clinical-immunological correlations . Ann Neurol . 1988;24:559-567.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Nov 1, 1991

References