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Antibiotics and Carbohydrate Malabsorption in Newborns

Antibiotics and Carbohydrate Malabsorption in Newborns Abstract In this issue, Bhatia et al1 report that full-term neonates who received parenteral antibiotics had a greater stool frequency, higher incidence of fecal-reducing substances, and greater requirement for dietary manipulation than did matched controls who did not receive antibiotics. Since all infants were receiving either a standard lactose-containing formula or breast milk and symptoms resolved by reducing the strength of the formula or by changing to a lactose-free formula, lactose malabsorption was implicated as the cause of these findings. From the data presented, it is difficult to ascertain the severity of the clinical problem. Although stool frequency was greater in the antibiotic-treated group, the difference was small (3.1 vs 2.2 stools per day). Body weight changes for the two groups are not given. The magnitude of caloric loss in stools was not quantitated. Yet, by clinical criteria alone, 14 of 25 infants in the antibiotic-treated References 1. Bhatia J, Prihoda AR, Richardson CJ: Parenteral antibiotics and carbohydrate intolerance in term neonates . AJDC 1986;140:111-113. 2. Davidson AGF, Mulleinger M: Reducing substances in neonatal stools detected by Clinitest . Pediatrics 1970;46:632-635. 3. Maclean WC Jr, Fink BB: Lactose malabsorption by premature infants: Magnitude and clinical significance . J Pediatr 1980;97:383-388.Crossref 4. Maclean WC Jr, Fink BB, Schoeller DA, et al: Lactose assimilation by full-term infants: Relation of [13C] and H2 breath tests with fecal [13C] excretion . Pediatr Res 1983;17:629-633.Crossref 5. Antonowicz I, Lebenthal E: Developmental pattern of small intestinal enterokinase and disaccharidase activities in the human fetus . Gastroenterology 1977;72:1299-1303. 6. Fulginiti VA: Bacterial infections in the newborn infant . J Pediatr 1970;76:646-648.Crossref 7. Aranda JV, Cohen S, Neims AH: Drug utilization in a newborn intensive care unit . J Pediatr 1976;89:315-317.Crossref 8. Aranda JV, Turmen T, Cote-Boileau T: Drug monitoring in the perinatal patient: Uses and abuses . Ther Drug Monit 1980;2:39-49.Crossref 9. ArandaJV, Portuguez-Malavasi A, Collinge JM, et al: Epidemiology of adverse drug reactions in the newborn . Dev Pharmacol Ther 1982; 5:173-184. 10. Philip AGS, Hewitt JR: Early diagnosis of neonatal sepsis . Pediatrics 1980;65:1036-1041. 11. Philip AGS: Decreased use of antibiotics using a neonatal sepsis screening technique . J Pediatr 1981;98:795-799.Crossref 12. StGemeJWJr, MurrayDL, Carter J, et al: Perinatal bacterial infection after prolonged rupture of amniotic membranes: An analysis of risk and management . J Pediatr 1984;104:608-613.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Antibiotics and Carbohydrate Malabsorption in Newborns

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Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1986.02140160019018
Publisher site
See Article on Publisher Site

Abstract

Abstract In this issue, Bhatia et al1 report that full-term neonates who received parenteral antibiotics had a greater stool frequency, higher incidence of fecal-reducing substances, and greater requirement for dietary manipulation than did matched controls who did not receive antibiotics. Since all infants were receiving either a standard lactose-containing formula or breast milk and symptoms resolved by reducing the strength of the formula or by changing to a lactose-free formula, lactose malabsorption was implicated as the cause of these findings. From the data presented, it is difficult to ascertain the severity of the clinical problem. Although stool frequency was greater in the antibiotic-treated group, the difference was small (3.1 vs 2.2 stools per day). Body weight changes for the two groups are not given. The magnitude of caloric loss in stools was not quantitated. Yet, by clinical criteria alone, 14 of 25 infants in the antibiotic-treated References 1. Bhatia J, Prihoda AR, Richardson CJ: Parenteral antibiotics and carbohydrate intolerance in term neonates . AJDC 1986;140:111-113. 2. Davidson AGF, Mulleinger M: Reducing substances in neonatal stools detected by Clinitest . Pediatrics 1970;46:632-635. 3. Maclean WC Jr, Fink BB: Lactose malabsorption by premature infants: Magnitude and clinical significance . J Pediatr 1980;97:383-388.Crossref 4. Maclean WC Jr, Fink BB, Schoeller DA, et al: Lactose assimilation by full-term infants: Relation of [13C] and H2 breath tests with fecal [13C] excretion . Pediatr Res 1983;17:629-633.Crossref 5. Antonowicz I, Lebenthal E: Developmental pattern of small intestinal enterokinase and disaccharidase activities in the human fetus . Gastroenterology 1977;72:1299-1303. 6. Fulginiti VA: Bacterial infections in the newborn infant . J Pediatr 1970;76:646-648.Crossref 7. Aranda JV, Cohen S, Neims AH: Drug utilization in a newborn intensive care unit . J Pediatr 1976;89:315-317.Crossref 8. Aranda JV, Turmen T, Cote-Boileau T: Drug monitoring in the perinatal patient: Uses and abuses . Ther Drug Monit 1980;2:39-49.Crossref 9. ArandaJV, Portuguez-Malavasi A, Collinge JM, et al: Epidemiology of adverse drug reactions in the newborn . Dev Pharmacol Ther 1982; 5:173-184. 10. Philip AGS, Hewitt JR: Early diagnosis of neonatal sepsis . Pediatrics 1980;65:1036-1041. 11. Philip AGS: Decreased use of antibiotics using a neonatal sepsis screening technique . J Pediatr 1981;98:795-799.Crossref 12. StGemeJWJr, MurrayDL, Carter J, et al: Perinatal bacterial infection after prolonged rupture of amniotic membranes: An analysis of risk and management . J Pediatr 1984;104:608-613.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Feb 1, 1986

References