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Antibiotics and Acid-Suppressing Medications in Early Life and Allergic Disorders—Reply

Antibiotics and Acid-Suppressing Medications in Early Life and Allergic Disorders—Reply Letters healthy obese individuals. Much attention has focused on adi- Antibiotics and Acid-Suppressing Medications pose tissue macrophages, but interestingly, adipocytes in Early Life and Allergic Disorders themselves may be more than just passive bystanders in “obe- To the Editor The study by Mitre et al is concerning given incom- sity-associated inflammation.” Adipocytes are capable of using plete acknowledgment of limitations and questionable accuracy conserved inflammatory pathways considered the hallmark of of associations between antireflux and antibiotic use indepen- myeloid and lymphoid cells. When white adipose tissue is ex- dently increasing the risk of developing allergic diseases. Using panded through adipocyte hypertrophy, fat cells adopt a pro- International Classification of Diseases, Ninth Revision codes to inflammatory secretory profile and release not only IL-32 but indicateadiagnosisofallergicconditionsisofteninaccuratewith- other immune mediators such as B-cell activating factor, tu- out additional encounter-level details verifying a history consis- mor necrosis factor, IL-1 β, IL-6, IL-8, leptin, resistin, and mono- tent with the condition and confirmatory testing. These diagno- cyte chemoattractant protein-1. The similarity to profes- ses were not linked to allergist referral and confirmatory coding, sional immune cells does not stop there. Adipocytes are also evidence of allergen sensitization, abnormal pulmonary func- known to express features http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Antibiotics and Acid-Suppressing Medications in Early Life and Allergic Disorders—Reply

JAMA Pediatrics , Volume 172 (10) – Oct 20, 2018

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Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/jamapediatrics.2018.2513
Publisher site
See Article on Publisher Site

Abstract

Letters healthy obese individuals. Much attention has focused on adi- Antibiotics and Acid-Suppressing Medications pose tissue macrophages, but interestingly, adipocytes in Early Life and Allergic Disorders themselves may be more than just passive bystanders in “obe- To the Editor The study by Mitre et al is concerning given incom- sity-associated inflammation.” Adipocytes are capable of using plete acknowledgment of limitations and questionable accuracy conserved inflammatory pathways considered the hallmark of of associations between antireflux and antibiotic use indepen- myeloid and lymphoid cells. When white adipose tissue is ex- dently increasing the risk of developing allergic diseases. Using panded through adipocyte hypertrophy, fat cells adopt a pro- International Classification of Diseases, Ninth Revision codes to inflammatory secretory profile and release not only IL-32 but indicateadiagnosisofallergicconditionsisofteninaccuratewith- other immune mediators such as B-cell activating factor, tu- out additional encounter-level details verifying a history consis- mor necrosis factor, IL-1 β, IL-6, IL-8, leptin, resistin, and mono- tent with the condition and confirmatory testing. These diagno- cyte chemoattractant protein-1. The similarity to profes- ses were not linked to allergist referral and confirmatory coding, sional immune cells does not stop there. Adipocytes are also evidence of allergen sensitization, abnormal pulmonary func- known to express features

Journal

JAMA PediatricsAmerican Medical Association

Published: Oct 20, 2018

References