CLINICAL SCIENCES Antibiotic Resistance of Ocular Surface Flora With Repeated Use of a Topical Antibiotic After Intravitreal Injection Vivian T. Yin, MD; Daniel J. Weisbrod, MD, FRCSC; Kenneth T. Eng, MD, FRCSC; Carol Schwartz, MD, FRCSC; Radha Kohly, MD, PhD, FRCSC; Efrem Mandelcorn, MD, FRCSC; Wai-Ching Lam, MD, FRCSC; Nick Daneman, MD, FRCPC; Andrew Simor, MD, FRCPC; Peter J. Kertes, MD, CM, FRCSC Importance: Treatment with intravitreal (IVT) injec- monthly for 3 months by change in minimal inhibitory tions has increased during the last several years as evi- concentration (MIC) of culture isolates was studied. dence has accumulated demonstrating the efficacy of anti–vascular endothelial growth factor agents in the Results: The study group consisted of 84 patients, and the treatment of neovascular age-related macular degen- control group had 94 patients. In the study group, the base- eration (AMD) and various retinal vascular diseases. line adjusted MIC increased (from 1.04 to 1.25 g/mL; Although IVT injections are generally safe, infectious P=.01) as did the MIC for 50% of isolates (MIC ) (from endophthalmitis is a rare but devastating complica- 0.64to1.00g/mL)andtheMICfor90%ofisolates(MIC ) tion, and the risk of morbidity and vision loss from (from 0.94 to 4.00 g/mL). In both groups, the
JAMA Ophthalmology – American Medical Association
Published: Apr 1, 2013
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