Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Anti–Retinal Pigment Epithelium Antibodies in Acute Exudative Polymorphous Vitelliform Maculopathy

Anti–Retinal Pigment Epithelium Antibodies in Acute Exudative Polymorphous Vitelliform Maculopathy CLINICAL SCIENCES Anti–Retinal Pigment Epithelium Antibodies in Acute Exudative Polymorphous Vitelliform Maculopathy A New Hypothesis About Disease Pathogenesis Larry Koreen, MD, PhD, MPH; Shirley X. He, MD; Mark W. Johnson, MD; Richard E. Hackel, MA; Naheed W. Khan, PhD; John R. Heckenlively, MD Objective: To investigate the etiology of acute exuda- tract demonstrated several antiretinal antibodies, as well tive polymorphous vitelliform maculopathy (AEPVM) in as anti-RPE antibodies against a 26-kDa protein that was a patient with metastatic melanoma, undiagnosed at ini- identified as peroxiredoxin 3 (PRDX3). Serum reactiv- tial examination, by testing for autoimmune mechanisms. ity against PRDX3 was greatly decreased in the conva- lescent-stage serum sample compared with the acute- stage serum sample, while results of retinal extract Methods: Serum samples were obtained from a 50-year- Western immunoblots remained essentially un- old man with AEPVM and metastatic unknown primary changed. Five separate serum samples from partici- melanoma during the acute stage and 3 years later when pants without AEPVM had no autoantibodies against subretinal fluid had resolved and melanoma was in re- PRDX3. mission (AEPVM convalescent stage). Western immu- noblots using both serum samples against human do- Conclusions: Paraneoplastic autoimmune reaction nor retinal extract and cultured primary human http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Ophthalmology American Medical Association

Anti–Retinal Pigment Epithelium Antibodies in Acute Exudative Polymorphous Vitelliform Maculopathy

Download PDF
7 pages

Loading next page...
 
/lp/american-medical-association/anti-retinal-pigment-epithelium-antibodies-in-acute-exudative-IIdirWNYk2

References (43)

Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6165
eISSN
2168-6173
DOI
10.1001/archophthalmol.2010.316
pmid
21220625
Publisher site
See Article on Publisher Site

Abstract

CLINICAL SCIENCES Anti–Retinal Pigment Epithelium Antibodies in Acute Exudative Polymorphous Vitelliform Maculopathy A New Hypothesis About Disease Pathogenesis Larry Koreen, MD, PhD, MPH; Shirley X. He, MD; Mark W. Johnson, MD; Richard E. Hackel, MA; Naheed W. Khan, PhD; John R. Heckenlively, MD Objective: To investigate the etiology of acute exuda- tract demonstrated several antiretinal antibodies, as well tive polymorphous vitelliform maculopathy (AEPVM) in as anti-RPE antibodies against a 26-kDa protein that was a patient with metastatic melanoma, undiagnosed at ini- identified as peroxiredoxin 3 (PRDX3). Serum reactiv- tial examination, by testing for autoimmune mechanisms. ity against PRDX3 was greatly decreased in the conva- lescent-stage serum sample compared with the acute- stage serum sample, while results of retinal extract Methods: Serum samples were obtained from a 50-year- Western immunoblots remained essentially un- old man with AEPVM and metastatic unknown primary changed. Five separate serum samples from partici- melanoma during the acute stage and 3 years later when pants without AEPVM had no autoantibodies against subretinal fluid had resolved and melanoma was in re- PRDX3. mission (AEPVM convalescent stage). Western immu- noblots using both serum samples against human do- Conclusions: Paraneoplastic autoimmune reaction nor retinal extract and cultured primary human

Journal

JAMA Ophthalmology – American Medical Association

Published: Jan 1, 2011

There are no references for this article.