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Anterior Segment Fluorophotometry in Acute Anterior Uveitis

Anterior Segment Fluorophotometry in Acute Anterior Uveitis Abstract • Anterior segment fluorophotometry was used to assess the severity of bloodaqueous barrier disruption in 25 patients with acute anterior uveitis. The results indicated that HLA-B27-positive patients had a more severe inflammation than did HLA-B27-negative patients, which was not discernible when judged by clinical signs and symptoms. Follow-up studies showed that the blood-aqueous barrier was disturbed for longer than the clinical signs indicated, and sometimes a temporary subclinical relapse was demonstrated on early withdrawal of topical therapy. The blood-aqueous barrier appeared to be restored after each attack of acute anterior uveitis in the majority of patients, with no evidence of progressive damage from repeated attacks. Our results indicated that fluorophotometry provides an objective and sensitive method of assessing anterior uveitis. References 1. Yourston D, Whicher J, Chambers R, et al: The acute phase response in acute anterior uveitis . Trans Ophthalmol Soc UK 1985;104:166-170. 2. Dunne JA, Jacobs N, Morrison A, et al: Efficacy in anterior uveitis of two known steroids and topical tolmetin . Br J Ophthalmol 1985;69:120-125.Crossref 3. Sanders DR, Kraff MC, Lieberman HL, et al: Breakdown and reestablishment of the bloodaqueous barrier with implant surgery . Arch Ophthalmol 1982;100:588-590.Crossref 4. Sanders DR, Spigelman A, Kraff C, et al: Quantitative assessment of postsurgical breakdown of the blood-aqueous barrier . Arch Ophthalmol 1983;101:131-133.Crossref 5. Sawa M, Sakanishi Y, Shimizu H: Fluorophotometric study of anterior segment barrier functions after extracapsular cataract extraction and posterior chamber intraocular lens implantation . Am J Ophthalmol 1984;97:197-204. 6. Miyake K, Asakura M, Kobayashi H: The effect of intraocular lens fixation on the blood-aqueous barrier . Am J Ophthalmol 1984;98:451-455.Crossref 7. Lugossy G: Fluorescein permeability of the blood-aqueous barrier . Adv Ophthalmol 1959;9:110-115. 8. Zeimer RC, Cunha-Vas JG, Johnson ME: Studies on the technique of vitreous fluorophotometry . Invest Ophthalmol Vis Sci 1982;22:668-674. 9. Zeimer RC, Blair NP, Cunha-Vas JG: Vitreous fluorophotometry for clinical research: I. Description and evaluation of a new fluorophotometer . Arch Ophthalmol 1983;101:1753-1756.Crossref 10. Chahal PS, Chowienczyk PJ, Kohner EM: Measurement of blood-retinal barrier permeability: A reproducibility study in normal eyes . Invest Ophthalmol Vis Sci 1985;26:977-982. 11. Miyake K, Asakura M, Maekubo K: Consensual reactions of human blood-aqueous barrier to implant operations . Arch Ophthalmol 1984;102:558-561.Crossref 12. Bennett PH, Wood PRN: New York criteria for diagnosing ankylosing spondylitis , in Bennett PH, Wood PRN (eds): Population Studies of the Rheumatic Diseases . Amsterdam, Exerpta Medica, 1968, p 457. 13. Zeimer RC, Blair NP, Cuhna-Vas JG: Vitreous fluorophotometry for clinical research: II. Method of data acquisition and processing . Arch Ophthalmol 1983;101:1757-1761.Crossref 14. Mapstone R, Woodrow JC: HL-A 27 and acute anterior uveitis . Br J Ophthalmol 1975;59:270-275.Crossref 15. Perkins ES: Uveitis in B27-related disease . Ann Rheum Dis 1979;38( (suppl 1) ):92-95.Crossref 16. Brewerton DA: The genetics of acute anterior uveitis . Trans Ophthalmol Soc UK 1985;104:242-246. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Anterior Segment Fluorophotometry in Acute Anterior Uveitis

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Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1987.01060110096040
Publisher site
See Article on Publisher Site

Abstract

Abstract • Anterior segment fluorophotometry was used to assess the severity of bloodaqueous barrier disruption in 25 patients with acute anterior uveitis. The results indicated that HLA-B27-positive patients had a more severe inflammation than did HLA-B27-negative patients, which was not discernible when judged by clinical signs and symptoms. Follow-up studies showed that the blood-aqueous barrier was disturbed for longer than the clinical signs indicated, and sometimes a temporary subclinical relapse was demonstrated on early withdrawal of topical therapy. The blood-aqueous barrier appeared to be restored after each attack of acute anterior uveitis in the majority of patients, with no evidence of progressive damage from repeated attacks. Our results indicated that fluorophotometry provides an objective and sensitive method of assessing anterior uveitis. References 1. Yourston D, Whicher J, Chambers R, et al: The acute phase response in acute anterior uveitis . Trans Ophthalmol Soc UK 1985;104:166-170. 2. Dunne JA, Jacobs N, Morrison A, et al: Efficacy in anterior uveitis of two known steroids and topical tolmetin . Br J Ophthalmol 1985;69:120-125.Crossref 3. Sanders DR, Kraff MC, Lieberman HL, et al: Breakdown and reestablishment of the bloodaqueous barrier with implant surgery . Arch Ophthalmol 1982;100:588-590.Crossref 4. Sanders DR, Spigelman A, Kraff C, et al: Quantitative assessment of postsurgical breakdown of the blood-aqueous barrier . Arch Ophthalmol 1983;101:131-133.Crossref 5. Sawa M, Sakanishi Y, Shimizu H: Fluorophotometric study of anterior segment barrier functions after extracapsular cataract extraction and posterior chamber intraocular lens implantation . Am J Ophthalmol 1984;97:197-204. 6. Miyake K, Asakura M, Kobayashi H: The effect of intraocular lens fixation on the blood-aqueous barrier . Am J Ophthalmol 1984;98:451-455.Crossref 7. Lugossy G: Fluorescein permeability of the blood-aqueous barrier . Adv Ophthalmol 1959;9:110-115. 8. Zeimer RC, Cunha-Vas JG, Johnson ME: Studies on the technique of vitreous fluorophotometry . Invest Ophthalmol Vis Sci 1982;22:668-674. 9. Zeimer RC, Blair NP, Cunha-Vas JG: Vitreous fluorophotometry for clinical research: I. Description and evaluation of a new fluorophotometer . Arch Ophthalmol 1983;101:1753-1756.Crossref 10. Chahal PS, Chowienczyk PJ, Kohner EM: Measurement of blood-retinal barrier permeability: A reproducibility study in normal eyes . Invest Ophthalmol Vis Sci 1985;26:977-982. 11. Miyake K, Asakura M, Maekubo K: Consensual reactions of human blood-aqueous barrier to implant operations . Arch Ophthalmol 1984;102:558-561.Crossref 12. Bennett PH, Wood PRN: New York criteria for diagnosing ankylosing spondylitis , in Bennett PH, Wood PRN (eds): Population Studies of the Rheumatic Diseases . Amsterdam, Exerpta Medica, 1968, p 457. 13. Zeimer RC, Blair NP, Cuhna-Vas JG: Vitreous fluorophotometry for clinical research: II. Method of data acquisition and processing . Arch Ophthalmol 1983;101:1757-1761.Crossref 14. Mapstone R, Woodrow JC: HL-A 27 and acute anterior uveitis . Br J Ophthalmol 1975;59:270-275.Crossref 15. Perkins ES: Uveitis in B27-related disease . Ann Rheum Dis 1979;38( (suppl 1) ):92-95.Crossref 16. Brewerton DA: The genetics of acute anterior uveitis . Trans Ophthalmol Soc UK 1985;104:242-246.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Nov 1, 1987

References