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Antenatal Acetaminophen Use and Attention-Deficit/Hyperactivity Disorder

Antenatal Acetaminophen Use and Attention-Deficit/Hyperactivity Disorder Opinion EDITORIAL Antenatal Acetaminophen Use and Attention-Deficit/Hyperactivity Disorder An Interesting Observed Association But Too Early to Infer Causality Miriam Cooper, MRCPsych, MSc; Kate Langley, PhD; Anita Thapar, FRCPsych, PhD Attention-deficit/hyperactivity disorder (ADHD) is the most of research designs that go beyond observational epidemiol- common childhood-onset neurodevelopmental disorder. ogy are necessary. Results should be interpreted cautiously for Although it is highly heritable, ADHD has a complex etiology, the following reasons. and noninherited factors also Acetaminophen is the most common drug used during 1 4 contribute. Early environ- pregnancy. Indeed, 56% of the participants in this cohort were Related article page 313 mental exposures that may exposed to the drug; however, factors that influence who takes cause neurobiological dys- the drug require consideration. Liew et al highlight that re- function and confer risk for ADHD (eg, lead and other toxins) sidual confounding may have been a possibility (eg, by ge- have been gaining increased attention of late. netic factors, unmeasured maternal psychopathology, expo- In this regard, an interesting new study in this issue of sure to other medications, or indication for drug use). With the journal has found preliminary evidence that prenatal regard to the indication for drug use, although it http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Antenatal Acetaminophen Use and Attention-Deficit/Hyperactivity Disorder

JAMA Pediatrics , Volume 168 (4) – Apr 1, 2014

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Publisher
American Medical Association
Copyright
Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/jamapediatrics.2013.5292
pmid
24566519
Publisher site
See Article on Publisher Site

Abstract

Opinion EDITORIAL Antenatal Acetaminophen Use and Attention-Deficit/Hyperactivity Disorder An Interesting Observed Association But Too Early to Infer Causality Miriam Cooper, MRCPsych, MSc; Kate Langley, PhD; Anita Thapar, FRCPsych, PhD Attention-deficit/hyperactivity disorder (ADHD) is the most of research designs that go beyond observational epidemiol- common childhood-onset neurodevelopmental disorder. ogy are necessary. Results should be interpreted cautiously for Although it is highly heritable, ADHD has a complex etiology, the following reasons. and noninherited factors also Acetaminophen is the most common drug used during 1 4 contribute. Early environ- pregnancy. Indeed, 56% of the participants in this cohort were Related article page 313 mental exposures that may exposed to the drug; however, factors that influence who takes cause neurobiological dys- the drug require consideration. Liew et al highlight that re- function and confer risk for ADHD (eg, lead and other toxins) sidual confounding may have been a possibility (eg, by ge- have been gaining increased attention of late. netic factors, unmeasured maternal psychopathology, expo- In this regard, an interesting new study in this issue of sure to other medications, or indication for drug use). With the journal has found preliminary evidence that prenatal regard to the indication for drug use, although it

Journal

JAMA PediatricsAmerican Medical Association

Published: Apr 1, 2014

References