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Annual High-Dose Oral Vitamin D and Falls and Fractures in Older Women

Annual High-Dose Oral Vitamin D and Falls and Fractures in Older Women ORIGINAL CONTRIBUTION Annual High-Dose Oral Vitamin D and Falls and Fractures in Older Women A Randomized Controlled Trial Kerrie M. Sanders, PhD Context Improving vitamin D status may be an important modifiable risk factor to re- Amanda L. Stuart, BappSc duce falls and fractures; however, adherence to daily supplementation is typically poor. Elizabeth J. Williamson, MA, PhD Objective To determine whether a single annual dose of 500 000 IU of cholecalcif- erol administered orally to older women in autumn or winter would improve adher- Julie A. Simpson, PhD ence and reduce the risk of falls and fracture. Mark A. Kotowicz, MBBS, FRACP Design, Setting, and Participants A double-blind, placebo-controlled trial of 2256 Doris Young, MD, MBBS, FRACGP community-dwelling women, aged 70 years or older, considered to be at high risk of fracture were recruited from June 2003 to June 2005 and were randomly assigned to Geoffrey C. Nicholson, PhD, FRACP receive cholecalciferol or placebo each autumn to winter for 3 to 5 years. The study HE RESULTS OF RANDOMIZED concluded in 2008. controlled trials investigating Intervention 500 000 IU of cholecalciferol or placebo. the effects of cholecalciferol Main Outcome Measures Falls and fractures were ascertained using monthly cal- T(vitamin http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Annual High-Dose Oral Vitamin D and Falls and Fractures in Older Women

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Publisher
American Medical Association
Copyright
Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2010.594
pmid
20460620
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Annual High-Dose Oral Vitamin D and Falls and Fractures in Older Women A Randomized Controlled Trial Kerrie M. Sanders, PhD Context Improving vitamin D status may be an important modifiable risk factor to re- Amanda L. Stuart, BappSc duce falls and fractures; however, adherence to daily supplementation is typically poor. Elizabeth J. Williamson, MA, PhD Objective To determine whether a single annual dose of 500 000 IU of cholecalcif- erol administered orally to older women in autumn or winter would improve adher- Julie A. Simpson, PhD ence and reduce the risk of falls and fracture. Mark A. Kotowicz, MBBS, FRACP Design, Setting, and Participants A double-blind, placebo-controlled trial of 2256 Doris Young, MD, MBBS, FRACGP community-dwelling women, aged 70 years or older, considered to be at high risk of fracture were recruited from June 2003 to June 2005 and were randomly assigned to Geoffrey C. Nicholson, PhD, FRACP receive cholecalciferol or placebo each autumn to winter for 3 to 5 years. The study HE RESULTS OF RANDOMIZED concluded in 2008. controlled trials investigating Intervention 500 000 IU of cholecalciferol or placebo. the effects of cholecalciferol Main Outcome Measures Falls and fractures were ascertained using monthly cal- T(vitamin

Journal

JAMAAmerican Medical Association

Published: May 12, 2010

References