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the initial to nickel The amount of nickel Cerebral Circulation General Anesthesia and exposure carbonyl. During Hy- in is of cancer the rat in Man: Induction to Nitrous capable inducing lung comparable perventilation Thiopental to amount the of nickel inhaled less Oxide and d-Tubocurarine—H. Wollman et al by persons smoking (3400 than 15 for a of a year. cigarettes per day period Spruce St, Philadelphia) rats to nickel The mean of 26:329 1965 weight chronically exposed Anesthesiology (May-June) to than and was found be less that of Studies of cerebral circulation gaseous metabolism carbonyl consistently the control rats the entire of were in six volunteers throughout three-year period performed healthy young during After two of chronic to nickel car¬ anesthesia induced with and maintained with study. years exposure thiopental the of deaths in the of nitrous oxide and d-tubocurarine. The blood bonyl, percentage exposed group thiopental measurements and rats was three times level was low when were approximately greater. very made, not to affect intravenous d-tubocurarine had been shown cerebral flow or metabolism. Therefore nitrous oxide 70% was for probably the agent chiefly responsible the changes Anesthesiology, Philadelphia observed. Pco2 cerebral blood When arterial was normal, flow remained but
JAMA – American Medical Association
Published: Jun 7, 1965
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