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Ankle Ulcer Sign of Werner's Syndrome

Ankle Ulcer Sign of Werner's Syndrome Abstract In 1934, Oppenheimer and Kugel1 distinguished the 2 conditions originally reported by Werner in 1904 and Rothmund in 1868 and established the criteria for the eponymic Werner's syndrome as we know it today. We are presenting another case of this rare disorder in which chromosomal studies were performed. The brother of the patient in question was briefly seen, but unfortunately could not be studied, although he also exhibited some classical signs of the same condition. The fully developed syndrome creates a remarkably constant picture, although incomplete forms have been reported. Detailed listings of these changes can be found in most of the medical literature on Werner's syndrome.2 In brief, the usual changes of this particular form of progeria are (a) premature senility (premature baldness and gray hair; juvenile cataracts, arteriosclerosis); (b) scleroderma-like changes, clinically not histologically (atrophic skin and loss of subcutaneous tissue; circumscribed hyperkeratosis of soles; tightness References 1. Oppenheimer, B. S., and Kugel, V. H.: Werner's Syndrome , Tr. Ass. Amer. Physicians , 49: 358, 1934. 2. Irwin, G. W., and Ward, P. B.: Werner's Syndrome: With a Report of Two Cases . Amer. J. Med. , 15:266, 1953.Crossref 3. Pillsbury, D. M.; Shelley, W. B., and Kligman, A. M.: Dermatology , Philadelphia, W. B. Saunders Company, 1956. 4. Perloff, J. K., and Phelps, E. T.: A Review of Werner's Syndrome: With a Report of the Second Autopsied Case , Ann. Intern. Med. , 48: 1205, 1958.Crossref 5. Motulsky, A. G.; Schultz, A., and Priest, J.: Werner's Syndrome: Chromosomes, Genes, and the Aging Process, Letters to the Editor , Lancet , 1:160, 1962.Crossref 6. Fraccaro, M.; Bott, M. G., and Calvert, H. T.: Chromosomes in Werner's Syndrome, Letters to the Editor , Lancet , 1:536, 1962.Crossref 7. Learner, N.; Day, H. J.; Weiss, L., and George, A. D.: Chromosomes in Werner's Syndrome, Letters to the Editor , Lancet , 1:536, 1962. 8. Arthur, R. P., and Shelley, W. B.: The Epidermal Biopsy: Its Indications and Technique , A.M.A. Arch. Derm. 80:95, 1959.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Ankle Ulcer Sign of Werner's Syndrome

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Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1963.01590130092014
Publisher site
See Article on Publisher Site

Abstract

Abstract In 1934, Oppenheimer and Kugel1 distinguished the 2 conditions originally reported by Werner in 1904 and Rothmund in 1868 and established the criteria for the eponymic Werner's syndrome as we know it today. We are presenting another case of this rare disorder in which chromosomal studies were performed. The brother of the patient in question was briefly seen, but unfortunately could not be studied, although he also exhibited some classical signs of the same condition. The fully developed syndrome creates a remarkably constant picture, although incomplete forms have been reported. Detailed listings of these changes can be found in most of the medical literature on Werner's syndrome.2 In brief, the usual changes of this particular form of progeria are (a) premature senility (premature baldness and gray hair; juvenile cataracts, arteriosclerosis); (b) scleroderma-like changes, clinically not histologically (atrophic skin and loss of subcutaneous tissue; circumscribed hyperkeratosis of soles; tightness References 1. Oppenheimer, B. S., and Kugel, V. H.: Werner's Syndrome , Tr. Ass. Amer. Physicians , 49: 358, 1934. 2. Irwin, G. W., and Ward, P. B.: Werner's Syndrome: With a Report of Two Cases . Amer. J. Med. , 15:266, 1953.Crossref 3. Pillsbury, D. M.; Shelley, W. B., and Kligman, A. M.: Dermatology , Philadelphia, W. B. Saunders Company, 1956. 4. Perloff, J. K., and Phelps, E. T.: A Review of Werner's Syndrome: With a Report of the Second Autopsied Case , Ann. Intern. Med. , 48: 1205, 1958.Crossref 5. Motulsky, A. G.; Schultz, A., and Priest, J.: Werner's Syndrome: Chromosomes, Genes, and the Aging Process, Letters to the Editor , Lancet , 1:160, 1962.Crossref 6. Fraccaro, M.; Bott, M. G., and Calvert, H. T.: Chromosomes in Werner's Syndrome, Letters to the Editor , Lancet , 1:536, 1962.Crossref 7. Learner, N.; Day, H. J.; Weiss, L., and George, A. D.: Chromosomes in Werner's Syndrome, Letters to the Editor , Lancet , 1:536, 1962. 8. Arthur, R. P., and Shelley, W. B.: The Epidermal Biopsy: Its Indications and Technique , A.M.A. Arch. Derm. 80:95, 1959.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Jan 1, 1963

References