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Gregory Brown, L. Curtsinger, J. Brightwell, D. Ackerman, G. Tobin, H. Polk, C. George-Nascimento, P. Valenzuela, G. Schultz (1986)
Enhancement of epidermal regeneration by biosynthetic epidermal growth factorThe Journal of Experimental Medicine, 163
W. Lawrence, J. Norton, M. Sporn, C. Gorschboth, Gary Grotendorst (1986)
The Reversal of an Adriamycin® Induced Healing Impairment with Chemoattractants and Growth FactorsAnnals of Surgery, 203
G. Schultz, M. White, R. Mitchell, Gregory Brown, J. Lynch, D. Twardzik, Todaro Gj (1987)
Epithelial wound healing enhanced by transforming growth factor-alpha and vaccinia growth factor.Science, 235 4786
M. Höckel, J. Sasse, J. Wissler (1987)
Purified monocyte‐derived angiogenic substance (angiotropin) stimulates migration, phenotypic changes, and “tube formation” but not proliferation of capillary endothelial cells in vitroJournal of Cellular Physiology, 133
J. Davidson, M. Klagsbrun, K. Hill, A. Buckley, R. Sullivan, P. Brewer, S. Woodward (1985)
Accelerated wound repair, cell proliferation, and collagen accumulation are produced by a cartilage-derived growth factorThe Journal of Cell Biology, 100
D. Knighton, K. Ciresi, V. Fiegel, L. Austin, E. Butler (1986)
Classification and treatment of chronic nonhealing wounds. Successful treatment with autologous platelet-derived wound healing factors (PDWHF).Annals of surgery, 204 3
I. Yannas, J. Burke, D. Orgill, E. Skrabut (1982)
Wound tissue can utilize a polymeric template to synthesize a functional extension of skin.Science, 215 4529
N. Dagalakis, J. Flink, P. Stasikelis, J. Burke, I. Yannas (1980)
Design of an artificial skin. Part III. Control of pore structure.Journal of biomedical materials research, 14 4
Michael, Walter, Jungt, Peter, Vaupel, Hartmut, Rabes, Cyrus Khaledpour, Josef, H. Wissler (1988)
Purified monocyte-derived angiogenic substance (angiotropin) induces controlled angiogenesis associated with regulated tissue proliferation in rabbit skin.The Journal of clinical investigation, 82 3
J. Niinikoski, L. Lebel, B. Gerdin (1986)
Stimulation of Wound Healing by Epidermal Growth FactorAnnals of Surgery, 203
Hunt Tk (1984)
Can repair processes be stimulated by modulators (cell growth factors, angiogenic factors, etc.) without adversely affecting normal processes?Journal of Trauma-injury Infection and Critical Care, 24
M. Sporn, A. Roberts, J. Shull, J. Smith, J. Ward, J. Sodek (1983)
Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo.Science, 219 4590
J. Burke, W. Quinby, C. Bondoc, W. Jung (1981)
Successful Use of a Physiologically Acceptable Artificial Skin in the Treatment of Extensive Burn InjuryAnnals of Surgery, 194
I. Yannas, J. Burke, P. Gordon, Chor Huang, R. Rubenstein (1980)
Design of an artificial skin. II. Control of chemical composition.Journal of biomedical materials research, 14 2
Ciresi KF Knighton DR (1986)
Classification and treatment of chronic nonhealing woundsAnn Surg, 204
R. Pearl (1981)
A Unifying Theory of the Delay Phenomenon– Recovery from the Hyperadrenergic StateAnnals of Plastic Surgery, 7
Thomas FACS, G. Pierce, A. Thomason, P. Gramates, M. Sporn, T. Deuel (1987)
Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta.Science, 237 4820
I. Yannas, J. Burke (1980)
Design of an artificial skin. I. Basic design principles.Journal of biomedical materials research, 14 1
Klagsbrun M Folkman J (1987)
Angiogenic factorsScience, 235
Anne Buckley, J. Davidson, Craig KAMERATHt, B. Terrill, WOLTt, S. Woodward (1985)
Sustained release of epidermal growth factor accelerates wound repair.Proceedings of the National Academy of Sciences of the United States of America, 82 21
H. Moses, R. Coffey, E. Leof, R. Lyons, J. Keski‐oja (1987)
Transforming growth factor β regulation of cell proliferationJournal of Cellular Physiology, 133
Logemann E Wissler JH (1986)
Structure and function of a monocytic blood vessel morphogen (angiotropin) for angiogenesis in vivo and in vitro: A copper-containing metallo-polyribonucleo-polypeptide as a novel and unique type of monokineProtides Biol Fluids, 34
M. Myers, G. Cherry (1967)
Augmentation of Tissue Survival by Delay: An Experimental Study in RabbitsPlastic and Reconstructive Surgery, 39
M. Höckel, T. Beck, J. Wissler (1984)
Neomorphogenesis of blood vessels in rabbit skin induced by a highly purified monocyte-derived polypeptide (monocyto-angiotropin) and associated tissue reactions.International journal of tissue reactions, 6 4
Abstract • Angiotropin is a potent angiogenesis factor isolated from the serum-free media of cultured, lectin-activated peripheral monocytes. In vitro, the purified substance stimulates migration, phenotypic differentiation, and tube formation, but not proliferation of capillary endothelial cells. When injected intradermally, angiotropin induces, in dose-dependent fashion, angiogenesis associated with skin hyperplasia. We have developed a flap model with insufficient blood supply and a model for contraction-free defect healing in rabbit skin. We show that (1) local pretreatment with angiotropin can prevent flap necrosis and (2) dermal regeneration after wounding can be augmented by angiotropin. From these results, we conclude that angiotropin might be of use as an adjuvant to healing in surgery. (Arch Surg 1989;124:693-698) References 1. Folkman J, Klagsbrun M: Angiogenic factors . Science 1987;235:442-447.Crossref 2. Hunt TK: Can repair processes be stimulated by modulators (cell growth factors, angiogenic factors, etc.) without adversely affecting normal processes? J Trauma 1984;24( (suppl 9) ):S39-S47. 3. Höckel M, Sasse J, Wissler JH: Purified monocyte-derived angiogenic substance (angiotropin) stimulates migration, phenotypic changes and 'tube formation' but not proliferation of capillary endothelial cells in vitro . J Cell Physiol 1987;133:1-13.Crossref 4. Wissler JH, Logemann E, Meyer HE, et al: Structure and function of a monocytic blood vessel morphogen (angiotropin) for angiogenesis in vivo and in vitro: A copper-containing metallo-polyribonucleo-polypeptide as a novel and unique type of monokine . Protides Biol Fluids 1986;34:525-536. 5. Höckel M, Jung W, Vaupel P, et al: Purified monocyte-derived angiogenic substance (angiotropin) induces controlled angiogenesis associated with regulated tissue proliferation in rabbit skin. J Clin Invest, in press. 6. Höckel M, Beck T, Wissler JH: Neomorphogenesis of blood vessels in rabbit skin induced by a highly purified monocyte-derived polypeptide (monocyto-angiotropin) and associated tissue reactions . Int J Tissue React 1984;6:323-331. 7. Myers MB, Cherry G: Augmentation of tissue survival by delay: An experimental study in rabbits . Plast Reconstr Surg 1967;39:397.Crossref 8. Pearl RM: A unifying theory of the delay phenomenon: Recovery from the hyperadrenergic state . Ann Plast Surg 1981;7:102-108.Crossref 9. Yannas IV, Burke JF: Design of an artificial skin: I. Basic design principles . J Biomed Mater Res 1980;14:65-81.Crossref 10. Yannas IV, Burke JF, Gordon PL, et al: Design of an artificial skin: II. Control of chemical composition . J Biomed Mater Res 1980;14:107-131.Crossref 11. Dagalakis N, Flink J, Stasikelis P, et al: Design of an artificial skin: III. Control of pore structure . J Biomed Mater Res 1980;14:511-528.Crossref 12. Burke JF, Yannas IV, Quinby WC, et al: Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury . Ann Surg 1981;194:413-428.Crossref 13. Yannas IV, Burke JF, Orgill DP, et al: Wound tissue can utilize a polymeric template to synthesize a functional extension of skin . Science 1982;215:174-176.Crossref 14. Sporn MB, Roberts AB, Shull JH, et al: Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo . Science 1983;219:1329-1331.Crossref 15. Buckley A, Davidson JM, Kamerath CD, et al: Sustained release of epidermal growth factor accelerates wound repair . Proc Natl Acad Sci USA 1985;82:7340-7344.Crossref 16. Davidson JM, Klagsbrun M, Hill KE, et al: Accelerated wound repair, cell proliferation, and collagen accumulation are produced by a cartilage-derived growth factor . J Cell Biol 1985;100:1219-1227.Crossref 17. Brown GL, Curtsinger L, Brightwell JR, et al: Enhancement of epidermal regeneration by biosynthetic epidermal growth factor . J Exp Med 1986;163:1319-1324.Crossref 18. Knighton DR, Ciresi KF, Fiegel VD, et al: Classification and treatment of chronic nonhealing wounds . Ann Surg 1986;204:322-330.Crossref 19. Laato M, Niinikoski J, Lebel L, et al: Stimulation of wound healing by epidermal growth factor . Ann Surg 1986;203:379-381.Crossref 20. Lawrence WT, Norton JA, Sporn MB, et al: The reversal of an Adriamycin induced healing impairment with chemoattractants and growth factors . Ann Surg 1986;203:142-147.Crossref 21. Mustoe TA, Pierce GF, Thomason A, et al: Accelerated healing of incisional wounds in rats induced by transforming growth factor-β . Science 1987;237:1333-1336.Crossref 22. Schultz GS, White M, Mitchell R, et al: Epithelial wound healing enhanced by transforming growth factor-α and vaccinia growth factor . Science 1987;235:350-352.Crossref
Archives of Surgery – American Medical Association
Published: Jun 1, 1989
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