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Angioimmunoblastic Lymphadenopathy With Paraproteinemia: Analysis of the Clinical and Biological Characteristics and Their Prognostic Significance

Angioimmunoblastic Lymphadenopathy With Paraproteinemia: Analysis of the Clinical and Biological... Abstract • We report a case of a double M component appearing in the course of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD). Lymphocyte function, especially the decrease in T-suppressor cells, could play an essential role in the mechanisms of the disease. In the presence of an M component, the prognosis for AILD seems to be more pessimistic. Arguments for considering AILD as a premalignant disease are reviewed. (Arch Intern Med 1984;144:2092-2093) References 1. Frizzera G, Moran EM, Rappaport H: Angioimmunoblastic lymphadenopathy with dysproteinemia . Lancet 1974;1:1070-1073.Crossref 2. Schauer PK, Straus DJ, Bagley CM, et al: Angioimmunoblastic lymphadenopathy: Clinical spectrum of disease . Cancer 1981;48:2493-2498.Crossref 3. Case records of the Massachusetts General Hospital: Case 11: 1980 . N Engl J Med 1980;302:678-684.Crossref 4. Boyum A: Separation of leucocytes from blood and bone marrow . Scand J Clin Invest 1968;21( (suppl 97) ):1-30. 5. Schandene L, Vandesteen F, Romasco F, et al: Active T rosettes, human autologous T rosettes, OKT8 and OKT4 cells, Con A-induced suppressor activity and autoantibodies: Clinical correlations . Clin Immunol Immunopathol 1983;28:147-154.Crossref 6. Bensa JC, Faure J, Martin M, et al: Levamisole in angioimmunoblastic lymphadenopathy . Lancet 1976;1:1081.Crossref 7. Bluming AZ, Cohen HG, Saxon A: Angioimmunoblastic lymphadenopathy with dysproteinemia: A pathogenetic link between physiologic lymphoid proliferation and malignant lymphoma . Am J Med 1979; 67:421-428.Crossref 8. Dujardin P, Audoly P, Cassuto JP: Les lymphadénopathies angioimmunoblastiques avec dysprotéinémie: Á propos de cinq observations . Sem Hop Paris 1977;53:1425-1429. 9. Iseman MD, Schwarz MI, Stanford RE: Interstitial pneumonia in angio-immunoblastic lymphadenopathy with dysproteinemia . Ann Intern Med 1976;85:752-755.Crossref 10. Palutke M, Khilanani P, Weise R: Immunologic and electromicroscopic characteristics of a case of immunoblastic lymphadenopathy . Am J Clin Pathol 1976;65:929-941. 11. Reinherz EL, Schlossman SF: Current concepts in immunology: Regulation of the immune response: Inducer and suppressor-T-lymphocytes subsets in human beings . N Engl J Med 1980;303:370-376.Crossref 12. Aizan AY, Zawadzki ZA, Micolonghi TS, et al: Vasculitis and Sjögren's syndrome with IgA-IgG cryoglobulinemia: Termination in immunoblastic sarcoma . Am J Med 1979;67:160-166.Crossref 13. Maltz LR, Papadimitriou JM, Carroll JR, et al: Angioimmunoblastic lymphadenopathy with dysproteinemia . Cancer 1977;40:2152-2160.Crossref 14. Flandrin G: Angioimmunoblastic lymphadenopathy: Clinical, biologic and follow-up study of 14 cases . Recent Results Cancer Res 1978;64: 241-262. 15. Ironside P, Cornell FN: Immunoblastic lymphadenopathy: A clinicopathological study of 16 cases . Pathology 1979;11:27-37.Crossref 16. Klajman A, Yaretzky A, Schneider M, et al: Angioimmunoblastic lymphadenopathy with paraproteinemia: A T- and B-cell disorder: Cancer 1981;48:2433-2437.Crossref 17. Abu-Zahra HT, McDonald DB, Home WI: Angioimmunoblastic lymphadenopathy with dysproteinemia . Lancet 1975;1:114-115.Crossref 18. Budman DR, Koziner B, Cunningham-Rundles C, et al: IgA deficiency associated with angioimmunoblastic lymphadenopathy . N Engl J Med 1978;298:1204. 19. Kaneko Y, Larson RA, Variakojis D, et al: Nonrandom chromosome abnormalities in angioimmunoblastic lymphadenopathy . Blood 1982;60: 877-887. 20. Moore SB, Harrison EG Jr, Weiland LH: Angioimmunoblastic lymphadenopathy . Mayo Clin Proc 1976;51:273-280. 21. Tangun Y, Saracbasi Z, Pekcelen Y, et al: Angioimmunoblastic lymphadenopathy dysproteinemia . Lancet 1974;1:1345-1346. 22. Pangalis GA, Moran EM, Nathawani BN, et al: Angioimmunoblastic lymphadenopathy: Long-term follow-up study . Cancer 1983;52:318-321.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Angioimmunoblastic Lymphadenopathy With Paraproteinemia: Analysis of the Clinical and Biological Characteristics and Their Prognostic Significance

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1984.04400010219041
Publisher site
See Article on Publisher Site

Abstract

Abstract • We report a case of a double M component appearing in the course of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD). Lymphocyte function, especially the decrease in T-suppressor cells, could play an essential role in the mechanisms of the disease. In the presence of an M component, the prognosis for AILD seems to be more pessimistic. Arguments for considering AILD as a premalignant disease are reviewed. (Arch Intern Med 1984;144:2092-2093) References 1. Frizzera G, Moran EM, Rappaport H: Angioimmunoblastic lymphadenopathy with dysproteinemia . Lancet 1974;1:1070-1073.Crossref 2. Schauer PK, Straus DJ, Bagley CM, et al: Angioimmunoblastic lymphadenopathy: Clinical spectrum of disease . Cancer 1981;48:2493-2498.Crossref 3. Case records of the Massachusetts General Hospital: Case 11: 1980 . N Engl J Med 1980;302:678-684.Crossref 4. Boyum A: Separation of leucocytes from blood and bone marrow . Scand J Clin Invest 1968;21( (suppl 97) ):1-30. 5. Schandene L, Vandesteen F, Romasco F, et al: Active T rosettes, human autologous T rosettes, OKT8 and OKT4 cells, Con A-induced suppressor activity and autoantibodies: Clinical correlations . Clin Immunol Immunopathol 1983;28:147-154.Crossref 6. Bensa JC, Faure J, Martin M, et al: Levamisole in angioimmunoblastic lymphadenopathy . Lancet 1976;1:1081.Crossref 7. Bluming AZ, Cohen HG, Saxon A: Angioimmunoblastic lymphadenopathy with dysproteinemia: A pathogenetic link between physiologic lymphoid proliferation and malignant lymphoma . Am J Med 1979; 67:421-428.Crossref 8. Dujardin P, Audoly P, Cassuto JP: Les lymphadénopathies angioimmunoblastiques avec dysprotéinémie: Á propos de cinq observations . Sem Hop Paris 1977;53:1425-1429. 9. Iseman MD, Schwarz MI, Stanford RE: Interstitial pneumonia in angio-immunoblastic lymphadenopathy with dysproteinemia . Ann Intern Med 1976;85:752-755.Crossref 10. Palutke M, Khilanani P, Weise R: Immunologic and electromicroscopic characteristics of a case of immunoblastic lymphadenopathy . Am J Clin Pathol 1976;65:929-941. 11. Reinherz EL, Schlossman SF: Current concepts in immunology: Regulation of the immune response: Inducer and suppressor-T-lymphocytes subsets in human beings . N Engl J Med 1980;303:370-376.Crossref 12. Aizan AY, Zawadzki ZA, Micolonghi TS, et al: Vasculitis and Sjögren's syndrome with IgA-IgG cryoglobulinemia: Termination in immunoblastic sarcoma . Am J Med 1979;67:160-166.Crossref 13. Maltz LR, Papadimitriou JM, Carroll JR, et al: Angioimmunoblastic lymphadenopathy with dysproteinemia . Cancer 1977;40:2152-2160.Crossref 14. Flandrin G: Angioimmunoblastic lymphadenopathy: Clinical, biologic and follow-up study of 14 cases . Recent Results Cancer Res 1978;64: 241-262. 15. Ironside P, Cornell FN: Immunoblastic lymphadenopathy: A clinicopathological study of 16 cases . Pathology 1979;11:27-37.Crossref 16. Klajman A, Yaretzky A, Schneider M, et al: Angioimmunoblastic lymphadenopathy with paraproteinemia: A T- and B-cell disorder: Cancer 1981;48:2433-2437.Crossref 17. Abu-Zahra HT, McDonald DB, Home WI: Angioimmunoblastic lymphadenopathy with dysproteinemia . Lancet 1975;1:114-115.Crossref 18. Budman DR, Koziner B, Cunningham-Rundles C, et al: IgA deficiency associated with angioimmunoblastic lymphadenopathy . N Engl J Med 1978;298:1204. 19. Kaneko Y, Larson RA, Variakojis D, et al: Nonrandom chromosome abnormalities in angioimmunoblastic lymphadenopathy . Blood 1982;60: 877-887. 20. Moore SB, Harrison EG Jr, Weiland LH: Angioimmunoblastic lymphadenopathy . Mayo Clin Proc 1976;51:273-280. 21. Tangun Y, Saracbasi Z, Pekcelen Y, et al: Angioimmunoblastic lymphadenopathy dysproteinemia . Lancet 1974;1:1345-1346. 22. Pangalis GA, Moran EM, Nathawani BN, et al: Angioimmunoblastic lymphadenopathy: Long-term follow-up study . Cancer 1983;52:318-321.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Oct 1, 1984

References