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Anemia During Acute Infections: Role of Glucose-6-Phosphate Dehydrogenase Deficiency in Negroes

Anemia During Acute Infections: Role of Glucose-6-Phosphate Dehydrogenase Deficiency in Negroes Abstract PHYSICIANS are often confronted with the problem of anemia occurring with various infectious diseases. Moderately severe anemia frequently develops during the course of chronic suppurative diseases,1-3 and presumably results primarily from depressed erythropoiesis. The less frequent anemia associated with acute infections usually has been assumed to result from elaboration of bacterial hemolysins, direct red blood cell (RBC) infestation, elevated titers of cold agglutinins, or transient hypersplenism.4 We had been impressed by the greater frequency of transient anemia during the course of acute bacterial infections in Negroes (30% to 40%) as compared to whites (5% to 10%) (in unpublished data). Furthermore, only rarely were any of the aforementioned mechanisms of anemia identified. In preliminary studies a few such patients were found to be deficient in the RBC enzyme glucose-6-phosphate dehydrogenase (G-6-PD). The present study was undertaken to determine if an association between G-6-PD deficiency and the occurrence of significant References 1. Bush, J.A., et al: The Anemia of Infection: XX. The Kinetics of Iron Metabolism in the Anemia Associated With Chronic Infection , J Clin Invest 35:89, 1956.Crossref 2. Cartwright, G.E., and Wintrobe, M.M.: The Anemia of Infection: XVII. A Review , Advances Intern Med 5:165, 1952. 3. Saiti, M.F., and Vaughn, J.M.: The Anaemia Associated With Infection , J Path Bact 56:189, 1944.Crossref 4. Jandl, J.H.; Jacob, H.S.; and Daland, G.A.: Hypersplenism Due to Infection: Study of Five Cases Manifesting Hemolytic Anemia , New Eng J Med 264:1063, 1961.Crossref 5. Cartwright, G.E.: Diagnostic Laboratory Hematology , ed 2, New York: Grune and Stratton, Inc, 1958. 6. Zinkham, W.H.; Lenhard, R.E.; and Childs, B.: A Deficiency of Glucose-6-Phosphate Dehydrogenase Activity in Erythrocytes From Patients With Favism , Bull J Hopkins Hosp 102:169, 1958. 7. Brown, G.M.: Pathogenesis of Secondary Anaemia , Canad Med Assoc J 62:472, 1951. 8. Fountain, J.R.: Blood Changes Associated With Disseminated Tuberculosis: Report of Four Fatal Cases and Review , Brit Med J 2:76, 1954.Crossref 9. Freireich, E.J., et al: Effect of Inflammation on the Utilization of Erythrocyte and Transferrin Bound Radioiron for Red Cell Production , Blood 12:972, 1957. 10. Vaughn, J.M., and Saiti, M.F.: Hemoglobin Metabolism in Chronic Infections , J Path Bact 49:69, 1939.Crossref 11. Burka, E.R.; Weaver, Z., III; and Marks, P.A.: Clinical Spectrum of Hemolytic Anemia Associated With Glucose-6-Phosphate Dehydrogenase Deficiency , Ann Intern Med 66:817, 1966.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Anemia During Acute Infections: Role of Glucose-6-Phosphate Dehydrogenase Deficiency in Negroes

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Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1967.00290210119011
Publisher site
See Article on Publisher Site

Abstract

Abstract PHYSICIANS are often confronted with the problem of anemia occurring with various infectious diseases. Moderately severe anemia frequently develops during the course of chronic suppurative diseases,1-3 and presumably results primarily from depressed erythropoiesis. The less frequent anemia associated with acute infections usually has been assumed to result from elaboration of bacterial hemolysins, direct red blood cell (RBC) infestation, elevated titers of cold agglutinins, or transient hypersplenism.4 We had been impressed by the greater frequency of transient anemia during the course of acute bacterial infections in Negroes (30% to 40%) as compared to whites (5% to 10%) (in unpublished data). Furthermore, only rarely were any of the aforementioned mechanisms of anemia identified. In preliminary studies a few such patients were found to be deficient in the RBC enzyme glucose-6-phosphate dehydrogenase (G-6-PD). The present study was undertaken to determine if an association between G-6-PD deficiency and the occurrence of significant References 1. Bush, J.A., et al: The Anemia of Infection: XX. The Kinetics of Iron Metabolism in the Anemia Associated With Chronic Infection , J Clin Invest 35:89, 1956.Crossref 2. Cartwright, G.E., and Wintrobe, M.M.: The Anemia of Infection: XVII. A Review , Advances Intern Med 5:165, 1952. 3. Saiti, M.F., and Vaughn, J.M.: The Anaemia Associated With Infection , J Path Bact 56:189, 1944.Crossref 4. Jandl, J.H.; Jacob, H.S.; and Daland, G.A.: Hypersplenism Due to Infection: Study of Five Cases Manifesting Hemolytic Anemia , New Eng J Med 264:1063, 1961.Crossref 5. Cartwright, G.E.: Diagnostic Laboratory Hematology , ed 2, New York: Grune and Stratton, Inc, 1958. 6. Zinkham, W.H.; Lenhard, R.E.; and Childs, B.: A Deficiency of Glucose-6-Phosphate Dehydrogenase Activity in Erythrocytes From Patients With Favism , Bull J Hopkins Hosp 102:169, 1958. 7. Brown, G.M.: Pathogenesis of Secondary Anaemia , Canad Med Assoc J 62:472, 1951. 8. Fountain, J.R.: Blood Changes Associated With Disseminated Tuberculosis: Report of Four Fatal Cases and Review , Brit Med J 2:76, 1954.Crossref 9. Freireich, E.J., et al: Effect of Inflammation on the Utilization of Erythrocyte and Transferrin Bound Radioiron for Red Cell Production , Blood 12:972, 1957. 10. Vaughn, J.M., and Saiti, M.F.: Hemoglobin Metabolism in Chronic Infections , J Path Bact 49:69, 1939.Crossref 11. Burka, E.R.; Weaver, Z., III; and Marks, P.A.: Clinical Spectrum of Hemolytic Anemia Associated With Glucose-6-Phosphate Dehydrogenase Deficiency , Ann Intern Med 66:817, 1966.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Mar 1, 1967

References