Abstract Introduction This paper is the second in a series of three summarizing 13 years of experience with the glutamic acid treatment of mental retardation and behavior disorders. In the first report1 results of a controlled experiment are presented, comparing the effectiveness of glutamic acid, reserpine, and a placebo in producing intellectual and behavioral alterations and revealing the nature, as well as the degrees, of change obtained with each drug. Findings indicated considerable overlapping between action of the two drugs, with response broad in scope but highly individualized.As we pointed out, emphasis in the past few years has shifted away from a narrow fixation upon change or lack of change in the intelligence quotient following treatment because of the realization that mentation is only one aspect of much broader Gestalten involving a wide variety of behavioral manifestations. In contrast to former reports, the crux of the matter has recently References 1. Zimmerman, F. T., and Burgemeister, B. B.: Arch. Neurol. & Psychiat. , this issue, p. 639. 2. Terman, L. M., and Merrill, M. A: Measuring Intelligence: A Guide to Administration of Revised Stanford-Binet Tests of Intelligence , Boston, Houghton Mifflin Company, 1937. 3. Stutsman, R.: Mental Measurement of Preschool Children , Yonkers-on-Hudson, World Book Company, 1931. 4. Pintner, R., and Paterson, D. G.: A Scale of Performance Tests , New York, D. Appleton & Co., 1917. 5. Rorschach, H.: Psychodiagnostik , Bern & Leipzig, E. Bircher, 1921. 6. Müller, H. W.: öffentliche Gesundheitsdienst 15:387, 1954. 7. Kane, E. D.: Am. J. Psychiat. 109:699, 1953. 8. Bergius, R.: Jahrb. Psychol. u. Psychotherap. 2:21, 1954. 9. Pile, W. J.: Dis. Nerv. System 13:106, 1952. 10. Ewalt, J. R., and Bruce, E. J.: Texas Rep. Biol. & Med. 6:97, 1948. 11. Kitzinger, H; De Vere, G. A.; Cartwright, R. W., and Shapiro, D.: Rorschach Res. Exchange 13:210, 1949. 12. Zabarenko, R. N., and Chambers, G. S.: Am. J. Psychiat. 108:881, 1952. 13. Himwich, H. E.: Wolff, K.; Hunsicker, A. L., and Himwich, W. A.: J. Nerve. & Ment. Dis. 121:40, 1955. 14. Klingmüller, V.: Biochemic, Physiologie und Klink der Glutaminsäure , edited by K. G. Cantor, Aulendorf i Wurtt, 1955.
A.M.A. Archives of Neurology & Psychiatry – American Medical Association
Published: May 1, 1959