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An Unusual Wart-like Skin Lesion Found in a Renal Allograft Recipient

An Unusual Wart-like Skin Lesion Found in a Renal Allograft Recipient Abstract • Immunosuppressed renal allograft recipients have an increased tendency to acquire warts. While studying such patients, we found a virus-induced, wart-like lesion that had an unusual histologic picture. Light microscopic studies showed bizarre keratinocytes with cytoplasmic, juxtanuclear, giant, crescentic bodies and round, nuclear inclusions. By electron microscopy, the giant cytoplasmic bodies were found to be composed of tonofilaments, and the nuclear inclusions were found to be composed of papillomavirus-like particles in a filamentous matrix. Typical papillomavirus particles were observed in a wart extract by the negative-staining method. Although virus was abundant in infected cells, no structural viral antigens of the human papillomavirus (HPV) types 1, 2, 3, or 5 could be detected by immunofluorescence microscopy, indicating infection by HPV 4 or some other, as yet undescribed, HPV type. (Arch Dermatol 117:43-46, 1981) References 1. Koranda FC, Dehmel EM, Kahn G, et al: Cutaneous complications in immunosuppressed renal homograft recipients . JAMA 229:419-424, 1974.Crossref 2. Mullen DL, Silverberg SG, Penn I, et al: Squamous cell carcinoma of the skin and lip in renal homograft recipients . Cancer 37:729-734, 1976.Crossref 3. Spencer ES, Andersen HK: Viral infections in renal allograft recipients treated with long-term immunosuppression . Br Med J 2:829-830, 1979.Crossref 4. Lutzner MA, Croissant O, Ducasse MF, et al: Potentially oncogenic human papillomavirus (HPV-5) found in two renal allograft recipients . J Invest Dermatol , to be published. 5. Orth G, Jablonska S, Favre M, et al: Characterization of two types of human papillomaviruses in lesions of epidermodysplasia verruciformis . Proc Natl Acad Sci USA 75:1537-1541, 1978.Crossref 6. Orth G, Favre M, Breitburd F, et al: Characteristics of the lesions and risk of malignant conversion associated with the type of human papillomavirus involved in epidermodysplasia verruciformis . Cancer Res 39:1074-1082, 1979. 7. Orth G, Jablonska S, Favre M, et al: Epidermodysplasia verruciformis: A model for the role of papillomaviruses in human cancer , in Essex M, Todaro G, zur Hausen H (eds): Cold Spring Harbor Conferences on Cell Proliferation: Viruses in Naturally Occurring Cancers . Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1980, vol 7. 8. Coggin JR Jr, zur Hausen H: Workshop on papillomaviruses and cancer . Cancer Res 39:545-546, 1979. 9. Orth G, Favre M, Croissant O: Characterization of a new type of human papillomavirus that causes skin warts . J Virol 24:108-120, 1977. 10. Gissmann L, Pfister H, zur Hausen H: Human papilloma viruses (HPV): Characterization of four different isolates . Virology 76:569-580, 1977.Crossref 11. Pass F, Reissig M, Shah KV, et al: Identification of an immunologically distinct papillomavirus from lesions of epidermodysplasia verruciformis . J Natl Cancer Inst 59:1107-1112, 1977. 12. Pfister H, Gross G, Hagedorn M: Characterization of human papilloma-virus 3 in warts of a renal allograft patient . J Invest Dermatol 73:349-353, 1979.Crossref 13. Laurent R, Coume-Marquet S, Kienzler JL, et al: Comparative electron microscopic study of clear cells in epidermodysplasia verruciformis and flat warts . Arch Dermatol Res 263:1-12, 1978.Crossref 14. Kaufmann J, Meves C, Ott F: Die Epidermodysplasia verruciformis Lewandowsky-Lutz in lichtund elektronenoptischem Vergleich mit den übrigen Papova-Virus-Akanthomen . Arch Dermatol Res 261:39-54, 1978.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

An Unusual Wart-like Skin Lesion Found in a Renal Allograft Recipient

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Publisher
American Medical Association
Copyright
Copyright © 1981 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1981.01650010049025
Publisher site
See Article on Publisher Site

Abstract

Abstract • Immunosuppressed renal allograft recipients have an increased tendency to acquire warts. While studying such patients, we found a virus-induced, wart-like lesion that had an unusual histologic picture. Light microscopic studies showed bizarre keratinocytes with cytoplasmic, juxtanuclear, giant, crescentic bodies and round, nuclear inclusions. By electron microscopy, the giant cytoplasmic bodies were found to be composed of tonofilaments, and the nuclear inclusions were found to be composed of papillomavirus-like particles in a filamentous matrix. Typical papillomavirus particles were observed in a wart extract by the negative-staining method. Although virus was abundant in infected cells, no structural viral antigens of the human papillomavirus (HPV) types 1, 2, 3, or 5 could be detected by immunofluorescence microscopy, indicating infection by HPV 4 or some other, as yet undescribed, HPV type. (Arch Dermatol 117:43-46, 1981) References 1. Koranda FC, Dehmel EM, Kahn G, et al: Cutaneous complications in immunosuppressed renal homograft recipients . JAMA 229:419-424, 1974.Crossref 2. Mullen DL, Silverberg SG, Penn I, et al: Squamous cell carcinoma of the skin and lip in renal homograft recipients . Cancer 37:729-734, 1976.Crossref 3. Spencer ES, Andersen HK: Viral infections in renal allograft recipients treated with long-term immunosuppression . Br Med J 2:829-830, 1979.Crossref 4. Lutzner MA, Croissant O, Ducasse MF, et al: Potentially oncogenic human papillomavirus (HPV-5) found in two renal allograft recipients . J Invest Dermatol , to be published. 5. Orth G, Jablonska S, Favre M, et al: Characterization of two types of human papillomaviruses in lesions of epidermodysplasia verruciformis . Proc Natl Acad Sci USA 75:1537-1541, 1978.Crossref 6. Orth G, Favre M, Breitburd F, et al: Characteristics of the lesions and risk of malignant conversion associated with the type of human papillomavirus involved in epidermodysplasia verruciformis . Cancer Res 39:1074-1082, 1979. 7. Orth G, Jablonska S, Favre M, et al: Epidermodysplasia verruciformis: A model for the role of papillomaviruses in human cancer , in Essex M, Todaro G, zur Hausen H (eds): Cold Spring Harbor Conferences on Cell Proliferation: Viruses in Naturally Occurring Cancers . Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1980, vol 7. 8. Coggin JR Jr, zur Hausen H: Workshop on papillomaviruses and cancer . Cancer Res 39:545-546, 1979. 9. Orth G, Favre M, Croissant O: Characterization of a new type of human papillomavirus that causes skin warts . J Virol 24:108-120, 1977. 10. Gissmann L, Pfister H, zur Hausen H: Human papilloma viruses (HPV): Characterization of four different isolates . Virology 76:569-580, 1977.Crossref 11. Pass F, Reissig M, Shah KV, et al: Identification of an immunologically distinct papillomavirus from lesions of epidermodysplasia verruciformis . J Natl Cancer Inst 59:1107-1112, 1977. 12. Pfister H, Gross G, Hagedorn M: Characterization of human papilloma-virus 3 in warts of a renal allograft patient . J Invest Dermatol 73:349-353, 1979.Crossref 13. Laurent R, Coume-Marquet S, Kienzler JL, et al: Comparative electron microscopic study of clear cells in epidermodysplasia verruciformis and flat warts . Arch Dermatol Res 263:1-12, 1978.Crossref 14. Kaufmann J, Meves C, Ott F: Die Epidermodysplasia verruciformis Lewandowsky-Lutz in lichtund elektronenoptischem Vergleich mit den übrigen Papova-Virus-Akanthomen . Arch Dermatol Res 261:39-54, 1978.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Jan 1, 1981

References