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An Unusual Case of T-Lymphocytic Leukemia With Coexpression of Helper and Suppressor Surface Markers

An Unusual Case of T-Lymphocytic Leukemia With Coexpression of Helper and Suppressor Surface Markers Abstract To the Editor.— T-cell prolymphocytic leukemia (T-PLL) represents a rare form of lymphoproliferative disorder that carries a grave prognostic consequence. We describe an unusual presentation of a case, and we believe that the pattern of immunophenotypic expression of the leukemic cells provides a useful distinguishing feature from other forms of leukemias/lymphomas. Report of a Case.— An 84-year-old white man presented in June 1989 with a 6-week history of a florid nonblanching macular erythema affecting the face and upper chest only (Figure). Physical examination was unremarkable; there was neither lymphadenopathy nor hepatosplenomegaly.Laboratory findings revealed marked leukocytosis with an atypical lymphocytosis of 36.9 × 109/L. The cytoplasm demonstrated deep basophilia, and the nuclei showed a regular outline with slight indentation. The nucleoli were inconspicuous under light microscopy. With the use of membrane marker analysis against a panel of monoclonal antibodies, the peripheral mononuclear cells demonstrated the following membrane markers: References 1. Matutes E, Talavera JG, O'Brien M, Catovsky D. The morphological spectrum of T-prolymphocytic leukaemia . Br J Haematol. 1986;64:111-124.Crossref 2. Costello C, Catovsky D, O'Brien M, and Galton DAG. Prolymphocytic leukaemia: an ultrastructural study of 22 cases . BrJ Haematol. 1980;44:389-394.Crossref 3. Catovsky D, Weschler A, Matutes E, et al. The membrane phenotype of T-prolymphocytic leukaemia . Scand J Haematol . 1982;29:398-404.Crossref 4. Suchi T, Lennert K, Tu LY, et al. Histopathology and immunohistochemistry of peripheral T-cell lymphomas: a proposal for their classification . J Clin Pathol. 1987;40:995-1015.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

An Unusual Case of T-Lymphocytic Leukemia With Coexpression of Helper and Suppressor Surface Markers

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Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1991.01680050155026
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— T-cell prolymphocytic leukemia (T-PLL) represents a rare form of lymphoproliferative disorder that carries a grave prognostic consequence. We describe an unusual presentation of a case, and we believe that the pattern of immunophenotypic expression of the leukemic cells provides a useful distinguishing feature from other forms of leukemias/lymphomas. Report of a Case.— An 84-year-old white man presented in June 1989 with a 6-week history of a florid nonblanching macular erythema affecting the face and upper chest only (Figure). Physical examination was unremarkable; there was neither lymphadenopathy nor hepatosplenomegaly.Laboratory findings revealed marked leukocytosis with an atypical lymphocytosis of 36.9 × 109/L. The cytoplasm demonstrated deep basophilia, and the nuclei showed a regular outline with slight indentation. The nucleoli were inconspicuous under light microscopy. With the use of membrane marker analysis against a panel of monoclonal antibodies, the peripheral mononuclear cells demonstrated the following membrane markers: References 1. Matutes E, Talavera JG, O'Brien M, Catovsky D. The morphological spectrum of T-prolymphocytic leukaemia . Br J Haematol. 1986;64:111-124.Crossref 2. Costello C, Catovsky D, O'Brien M, and Galton DAG. Prolymphocytic leukaemia: an ultrastructural study of 22 cases . BrJ Haematol. 1980;44:389-394.Crossref 3. Catovsky D, Weschler A, Matutes E, et al. The membrane phenotype of T-prolymphocytic leukaemia . Scand J Haematol . 1982;29:398-404.Crossref 4. Suchi T, Lennert K, Tu LY, et al. Histopathology and immunohistochemistry of peripheral T-cell lymphomas: a proposal for their classification . J Clin Pathol. 1987;40:995-1015.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Jun 1, 1991

References