Abstract Objectives: To describe a patient who developed an unusual polyneuropathy after treatment with interferon alfa-2a for hepatitis C and to discuss issues related to diagnosis and pathogenesis. Design: Case report. Setting: Tertiary care center. Case: A 46-year-old man with chronic hepatitis C had acute onset of an axonal polyneuropathy with prominent smallfiber involvement shortly after completing a standard 6-month course of therapy with low-dose interferon alfa-2a. Main Outcome and Results: Further interferon treatment for hepatitis C was discontinued. Conclusion: Standard, low-dose interferon alfa-2a treatment can produce a persistent predominantly smallfiber polyneuropathy. References 1. Smedley H, Katrak M, Sikora K, Wheeler T. Neurological effects of recombinant human interferon . BMJ . 1983;286:262-264.Crossref 2. Bernsen PLJA, Chung RE Wong, Vingerhoets HM, Janssen JTP. Bilateral neuralgic amyotrophy induced by interferon treatment . Arch Neurol . 1988;45:449-451.Crossref 3. Cudillo L, Cantonetti M, Venditti A, et al. Peripheral polyneuropathy during treatment with alpha-2 interferon . Haematologica . 1990;75:485-486. 4. Sakajiri K, Takamori M. Multiple mononeuropathy during recombinant interferonalpha 2a therapy for chronic hepatitis C . Rinsho Shinkeigaku . 1992;32:1041-1043. 5. Negoro K, Fukusako T, Morimatsu M, Liao C. Acute axonal polyneuropathy during interferon α-2A therapy for chronic hepatitis type C . Muscle Nerve . 1994;17:1351-1352. 6. Shin OJ. Clinical Electromyography: Nerve Conduction Studies . 2nd ed. Baltimore, Md: Williams & Wilkins; 1993.
Archives of Neurology – American Medical Association
Published: Jul 1, 1997
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