Abstract The pharmacologic action of aconite indicates that the drug should be of distinct use in the treatment of heart disease. The effect of the active principle of the drug, aconitin, on the mammalian heart was studied by Matthews,1 who described two stages of aconitin poisoning. During the first stage there was slowing of the heart with weakening of systole. The heart-rate was sometimes reduced one-half or onethird of the original rate with a corresponding lowering of the bloodpressure. These effects seemed to be entirely due to central vagus stimulation, as they disappeared after the administration of atropin or after cutting the vagi. During the second stage tachycardia and arhythmia appeared, apparently caused by the action of the drug directly on the heart muscle. Matthews considers that the drug might be employed therapeutically in such doses that the effects of the first stage alone are obtained References 1. Matthews : A Study of the Action of Aconitin on the Mammalian Heart and Circulation , Jour. Exper. Med. , 1897, ii, 593.Crossref 2. Rudolf and Cole : The Effects of Medicinal Doses of Aconite upon the Pulse-Rate , Am. Jour. Med. Sc. , 1912, cxliv, 788.Crossref 3. Price : Recent Advances in the Diagnosis, Prognosis and Treatment of Heart Disease: The Polyograph , Brit. Med. Jour. , 1913, i, 477.Crossref 4. Piersol : The Management of High Blood-Pressure , Therap. Gaz. , 1913, xxxvii. 5. Winterberg: Ueber die Wirkung des Physostigmin auf das Warmbluterherz , Ztschr. f. exper. Path. u. Therap. , 1907, iv, 636.Crossref 6. Kaufmann: Physostigmin in Tachycardia , Wien. klin. Wchnschr. , 1912, xxv. 7. Roth: The Physiological Assay of Aconite , Jour. Am. Pharm. Assn. , 1913, ii, 705. 8. Wood : The Purpose and Limitations of Bio-Assay , Jour. Am. Med. Assn. , 1912, lix, 1433.Crossref 9. Cushny: Irregularities of the Mammalian Heart Observed Under Aconitin and on Electrical Stimulation , Heart , 1909, i, 1.
Archives of Internal Medicine – American Medical Association
Published: May 1, 1915
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera