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AN INVESTIGATION OF THE POTENCY OF TINCTURE OF ACONITE

AN INVESTIGATION OF THE POTENCY OF TINCTURE OF ACONITE Abstract The pharmacologic action of aconite indicates that the drug should be of distinct use in the treatment of heart disease. The effect of the active principle of the drug, aconitin, on the mammalian heart was studied by Matthews,1 who described two stages of aconitin poisoning. During the first stage there was slowing of the heart with weakening of systole. The heart-rate was sometimes reduced one-half or onethird of the original rate with a corresponding lowering of the bloodpressure. These effects seemed to be entirely due to central vagus stimulation, as they disappeared after the administration of atropin or after cutting the vagi. During the second stage tachycardia and arhythmia appeared, apparently caused by the action of the drug directly on the heart muscle. Matthews considers that the drug might be employed therapeutically in such doses that the effects of the first stage alone are obtained References 1. Matthews : A Study of the Action of Aconitin on the Mammalian Heart and Circulation , Jour. Exper. Med. , 1897, ii, 593.Crossref 2. Rudolf and Cole : The Effects of Medicinal Doses of Aconite upon the Pulse-Rate , Am. Jour. Med. Sc. , 1912, cxliv, 788.Crossref 3. Price : Recent Advances in the Diagnosis, Prognosis and Treatment of Heart Disease: The Polyograph , Brit. Med. Jour. , 1913, i, 477.Crossref 4. Piersol : The Management of High Blood-Pressure , Therap. Gaz. , 1913, xxxvii. 5. Winterberg: Ueber die Wirkung des Physostigmin auf das Warmbluterherz , Ztschr. f. exper. Path. u. Therap. , 1907, iv, 636.Crossref 6. Kaufmann: Physostigmin in Tachycardia , Wien. klin. Wchnschr. , 1912, xxv. 7. Roth: The Physiological Assay of Aconite , Jour. Am. Pharm. Assn. , 1913, ii, 705. 8. Wood : The Purpose and Limitations of Bio-Assay , Jour. Am. Med. Assn. , 1912, lix, 1433.Crossref 9. Cushny: Irregularities of the Mammalian Heart Observed Under Aconitin and on Electrical Stimulation , Heart , 1909, i, 1. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

AN INVESTIGATION OF THE POTENCY OF TINCTURE OF ACONITE

Archives of Internal Medicine , Volume XV (5_1) – May 1, 1915

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Publisher
American Medical Association
Copyright
Copyright © 1915 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1915.00070230002001
Publisher site
See Article on Publisher Site

Abstract

Abstract The pharmacologic action of aconite indicates that the drug should be of distinct use in the treatment of heart disease. The effect of the active principle of the drug, aconitin, on the mammalian heart was studied by Matthews,1 who described two stages of aconitin poisoning. During the first stage there was slowing of the heart with weakening of systole. The heart-rate was sometimes reduced one-half or onethird of the original rate with a corresponding lowering of the bloodpressure. These effects seemed to be entirely due to central vagus stimulation, as they disappeared after the administration of atropin or after cutting the vagi. During the second stage tachycardia and arhythmia appeared, apparently caused by the action of the drug directly on the heart muscle. Matthews considers that the drug might be employed therapeutically in such doses that the effects of the first stage alone are obtained References 1. Matthews : A Study of the Action of Aconitin on the Mammalian Heart and Circulation , Jour. Exper. Med. , 1897, ii, 593.Crossref 2. Rudolf and Cole : The Effects of Medicinal Doses of Aconite upon the Pulse-Rate , Am. Jour. Med. Sc. , 1912, cxliv, 788.Crossref 3. Price : Recent Advances in the Diagnosis, Prognosis and Treatment of Heart Disease: The Polyograph , Brit. Med. Jour. , 1913, i, 477.Crossref 4. Piersol : The Management of High Blood-Pressure , Therap. Gaz. , 1913, xxxvii. 5. Winterberg: Ueber die Wirkung des Physostigmin auf das Warmbluterherz , Ztschr. f. exper. Path. u. Therap. , 1907, iv, 636.Crossref 6. Kaufmann: Physostigmin in Tachycardia , Wien. klin. Wchnschr. , 1912, xxv. 7. Roth: The Physiological Assay of Aconite , Jour. Am. Pharm. Assn. , 1913, ii, 705. 8. Wood : The Purpose and Limitations of Bio-Assay , Jour. Am. Med. Assn. , 1912, lix, 1433.Crossref 9. Cushny: Irregularities of the Mammalian Heart Observed Under Aconitin and on Electrical Stimulation , Heart , 1909, i, 1.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: May 1, 1915

References

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