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An Interpretive Summary of the Bermuda Workshop

An Interpretive Summary of the Bermuda Workshop Abstract This summary was prepared to share with a broader audience some of the observations and concepts developed during the workshop and to discuss certain implications of these which in our opinion may be useful to colleagues for future experiments. The summary contains three topics: (1) the pathobiology of cell systems in the lung (2) types of models, and (3) relevance of model systems to man. Pathobiology of the Lung The primary response to inhaled materials is found at the cell level with later changes in physiological functions such as pulmonary clearance and airway dynamics. Modern techniques have made it possible to detect these changes at the subcellular levels as ultrastructural or biochemical changes which may alter the functions of cells as biochemical synthesis systems, energy transfer systems, and proliferating populations.The knowledge is still incomplete concerning the types of cells in the lungs, their functions and the materials being References 1. Kilburn KH, Salzano J (eds): Symposium on the structure, function and measurement of respiratory cilia . Amer Rev Resp Dis 93:1-184, 1966. 2. Saffiotti U: Experimental respiratory tract carcinogenesis and its relation to inhalation exposures. Read before the Conference on Inhalation Carcinogenesis, Gatlinburg, Tenn, 1969. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

An Interpretive Summary of the Bermuda Workshop

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Publisher
American Medical Association
Copyright
Copyright © 1970 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1970.00310090138019
Publisher site
See Article on Publisher Site

Abstract

Abstract This summary was prepared to share with a broader audience some of the observations and concepts developed during the workshop and to discuss certain implications of these which in our opinion may be useful to colleagues for future experiments. The summary contains three topics: (1) the pathobiology of cell systems in the lung (2) types of models, and (3) relevance of model systems to man. Pathobiology of the Lung The primary response to inhaled materials is found at the cell level with later changes in physiological functions such as pulmonary clearance and airway dynamics. Modern techniques have made it possible to detect these changes at the subcellular levels as ultrastructural or biochemical changes which may alter the functions of cells as biochemical synthesis systems, energy transfer systems, and proliferating populations.The knowledge is still incomplete concerning the types of cells in the lungs, their functions and the materials being References 1. Kilburn KH, Salzano J (eds): Symposium on the structure, function and measurement of respiratory cilia . Amer Rev Resp Dis 93:1-184, 1966. 2. Saffiotti U: Experimental respiratory tract carcinogenesis and its relation to inhalation exposures. Read before the Conference on Inhalation Carcinogenesis, Gatlinburg, Tenn, 1969.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Sep 1, 1970

References