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An Experimental Study of Pancreatic Trauma and Its Relationship to Pancreatic Inflammation

An Experimental Study of Pancreatic Trauma and Its Relationship to Pancreatic Inflammation Abstract Introduction Pancreatitis may follow severe abdominal trauma or a surgical procedure and often represents a catastrophic complication. Massive fluid extravasation and electrolyte depletion result in hypovolemia with progressive shock which may convert a serious condition into a fatal one. While pancreatitis has been reported to follow a variety of operations, upper abdominal surgery, particularly gastric or biliary operations, are the most common antecedent procedures.4,5Biliary operations which involve instrumentation of the common duct, dilation of the ampulla, or section of the intrinsic sphincter muscle appear to predispose to this complication. Furthermore, insertion of a long-limbed T tube through the papilla of the bile duct into the duodenum has frequently been implicated in the causation of pancreatitis.7 In such instances, pancreatic duct obstruction would seem to play an important role.8Direct trauma to the pancreas, resulting from external blunt or penetrating injuries, may cause obstruction or laceration of References 1. Anderson, M. C., and Bergan, J. J.: The Significance of Vascular Injury as a Factor in the Pathogenesis of Pancreatitis , Ann Surg 54:58-67, 1961.Crossref 2. Burnett, W. E.; Rosemond, G. P.; Caswell, H. T.; Beauchamp, E. W.; Tyson, R. R.; and Wright, W. C.: Studies on So-Called Postgastrectomy Pancreatitis , Ann Surg 149:737-745, 1959.Crossref 3. Dreiling, D. A.: Experimental Pancreatitis: A Critical Review , J Mount Sinai Hosp NY 25: 128-136, 1958. 4. Ferris, D. O.; Lynn, T. E.; Cain, J. C.; and Baggenstoss, A. H.: Fatal Postoperative Pancreatitis , Ann Surg 146:263-273, 1957.Crossref 5. Pendower, J. E. H., and Tanner, N. C.: Pancreatitis Following Gastrectomy , Brit J Surg 47: 145-147, 1959.Crossref 6. Ponka, J. L.; Landrum, S. E.; and Chaikof, L.: Acute Pancreatitis in the Postoperative Patient , Arch Surg 83:475-490, 1961.Crossref 7. Smith, S. W.; Barker, W. F.; and Kaplan, L.: Acute Pancreatitis Following Transampullary Biliary Drainage , Surgery 30:695, 1951. 8. Telford, D.: Postoperative Acute Pancreatitis , Canad J Surg 2:22-28, 1958. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

An Experimental Study of Pancreatic Trauma and Its Relationship to Pancreatic Inflammation

Archives of Surgery , Volume 86 (6) – Jun 1, 1963

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Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1963.01310120162023
Publisher site
See Article on Publisher Site

Abstract

Abstract Introduction Pancreatitis may follow severe abdominal trauma or a surgical procedure and often represents a catastrophic complication. Massive fluid extravasation and electrolyte depletion result in hypovolemia with progressive shock which may convert a serious condition into a fatal one. While pancreatitis has been reported to follow a variety of operations, upper abdominal surgery, particularly gastric or biliary operations, are the most common antecedent procedures.4,5Biliary operations which involve instrumentation of the common duct, dilation of the ampulla, or section of the intrinsic sphincter muscle appear to predispose to this complication. Furthermore, insertion of a long-limbed T tube through the papilla of the bile duct into the duodenum has frequently been implicated in the causation of pancreatitis.7 In such instances, pancreatic duct obstruction would seem to play an important role.8Direct trauma to the pancreas, resulting from external blunt or penetrating injuries, may cause obstruction or laceration of References 1. Anderson, M. C., and Bergan, J. J.: The Significance of Vascular Injury as a Factor in the Pathogenesis of Pancreatitis , Ann Surg 54:58-67, 1961.Crossref 2. Burnett, W. E.; Rosemond, G. P.; Caswell, H. T.; Beauchamp, E. W.; Tyson, R. R.; and Wright, W. C.: Studies on So-Called Postgastrectomy Pancreatitis , Ann Surg 149:737-745, 1959.Crossref 3. Dreiling, D. A.: Experimental Pancreatitis: A Critical Review , J Mount Sinai Hosp NY 25: 128-136, 1958. 4. Ferris, D. O.; Lynn, T. E.; Cain, J. C.; and Baggenstoss, A. H.: Fatal Postoperative Pancreatitis , Ann Surg 146:263-273, 1957.Crossref 5. Pendower, J. E. H., and Tanner, N. C.: Pancreatitis Following Gastrectomy , Brit J Surg 47: 145-147, 1959.Crossref 6. Ponka, J. L.; Landrum, S. E.; and Chaikof, L.: Acute Pancreatitis in the Postoperative Patient , Arch Surg 83:475-490, 1961.Crossref 7. Smith, S. W.; Barker, W. F.; and Kaplan, L.: Acute Pancreatitis Following Transampullary Biliary Drainage , Surgery 30:695, 1951. 8. Telford, D.: Postoperative Acute Pancreatitis , Canad J Surg 2:22-28, 1958.

Journal

Archives of SurgeryAmerican Medical Association

Published: Jun 1, 1963

References