Abstract Introduction The purpose of this paper is to present a simple formula permitting rapid calculation of the following data essential to the performance of an exchange transfusion for an infant, child, or adult: (a) the volume of donor blood needed; (b) the length of time required to perform the exchange transfusion; (c) the number of "unit exchanges" required; (d) the per cent exchange effected.The formula will be presented after a discussion of background material essential to its effective application. Four typical problems are then discussed, followed by a summary. Derivation of the formula and related subjects are given in an appendix. The Exchange Transfusion Since 1946 the exchange transfusion has become the accepted method in treatment of erythroblastosis fetalis.1-3 Since 1950 exchange transfusions have been used to treat blood transfusion reactions4 and poisoning when conventional methods have failed. Poisoning by the following substances has been treated successfully References 1. Hart, A. P.: Familial Icterus Gravis of the New-Born and Its Treatment , Canad. M.A.J. 15: 1008, 1925. 2. Wallerstein H.: Treatment of Severe Erythroblastosis by Simultaneous Removal and Replacement of Blood of Newborn Infant , Science 103:583, 1946.Crossref 3. Allen, F. H., and Diamond, L. K.: Erythroblastosis Fetalis Including Exchange Transfusion Technic , Boston, Little Brown & Company, 1958. 4. Rutherford, P. S.: Hemolytic Blood Transfusion Reaction Treated by Replacement Transfusion , Am. J. Clin. Path. 23:1059, 1953. 5. Axtrup, S.: Exchange Transfusion as a Treatment in Poisoning , Acta paediat. 39:541, 1950.Crossref 6. Boggs, T. R., Jr., and Anrode, H. G.: Boric Acid Poisoning Treated by Exchange Transfusion , Pediatrics 16:109, 1955. 7. Radebaugh, J. F., Jr., and Emery, F. C.: Salicylate Poisoning Treatment with Replacement Transfusion: A Case Report , J. Maine M.A. 48:437, 1957. 8. Done, A. K., and Otterness, L. J.: Exchange Transfusion in the Treatment of Oil of Wintergreen (Methyl Salicylate) Poisoning , Pediatrics 18:80, 1956. 9. Katz, B. E., and Carver, M. W.: Acute Poisoning with Isoniazid Treated by Exchange Transfusion , Pediatrics 18:72, 1956. 10. Petit, R., and Herbaut, M.: Exsanguination Transfusion in a Case of Accidental Butazolidin Poisoning in an Infant of 15 Months , Bruxelle-méd. 35:1294, 1955. 11. Trossman, C. M., and Madison, M.: Donnatal Poisoning Treated by Exchange Transfusion in a 2-Year-Old, to be reported. 12. Wintrobe, M.: Clinical Hematology , Ed. 4, Philadelphia, Lea & Febiger, 1956, Chap. 6 , pp. 304-310; 322-323. 13. Kolff, W. J.; Watschinger, B., and Vertes, V.: Results in Patients Treated with the Coil Kidney (Disposable Dialyzing Unit) , J.A.M.A. 161:1433, 1956.Crossref 14. Wiener, A. S., and Wexler, I. B.: The Use of Heparin When Performing Exchange Blood Transfusions , J. Lab. & Clin. Med. 31: 1016, 1946.
A.M.A. Journal of Diseases of Children – American Medical Association
Published: Dec 1, 1959