Abstract Although chronic renal disease is well known as one of the most frequent causes of growth retardation in children, details of the nature of the dependence of growth on kidney function have received little attention. It is obvious that when renal disease has become advanced, the complication of renal rickets provides an explanation for growth retardation, and it is on the marked dwarfism associated with this complication that pediatric texts and treatises on growth and development usually focus attention. The retardation of growth frequently seen in renal disease in the absence of rickets has not, to our knowledge, been specifically studied. The growth failure of renal disease is usually classed as dwarfism associated with metabolic or organic disorder,* a category into which also fall growth failures resulting from heart disease, liver disease and such diseases of the intestine as celiac disease, pancreatic fibrosis, and megacolon. With the latter diseases, the References 1. 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Invest. 27:198 ( (March) ) 1948. 25. Cotlove, E.; Holliday, M. A.; Schwartz, R., and Wallace, W. M.: Effects of Electrolyte Depletion and Acid-Base Disturbance on Muscle Cations , Am. J. Physiol. 167:665 ( (Dec.) ) 1951. 26. Browne, J. S. L., and Vineberg, A. M.: Inter-Dependence of Gastric Secretion and CO2 Content of Blood , J. Physiol. 75:345 ( (July) ) 1932. 27. Sherman, H. C., and MacLeod, F. L.: Calcium Content of the Body in Relation to Age, Growth, and Food , J. Biol. Chem. 64:429 ( (June) ) 1925. 28. Sherman, H. C., and Booher, L. E.: Calcium Content of the Body in Relation to that of Food , J. Biol. Chem. 93:93 ( (Sept.) ) 1931. 29. Toepfer, E. W., and Sherman, H. C.: Effect of Liberal Intakes of Calcium or Calcium and Phosphorus on Growth and Body Calcium , J. Biol. Chem. 115:685 ( (Oct.) ) 1936. 30. Wells, B. B.: Influence of Crystalline Compounds Separated from Adrenal Cortex on Gluconeogenesis , Proc. Staff Meet. Mayo Clin. 15:294 ( (May 8) ) 1940. 31. Marx, W.; Simpson, M. E.; Li, C. H., and Evans, H. M.: Antagonism of Pituitary Adrenocorticotropic Hormone to Growth Hormone in Hypophysectomized Rats , Endocrinology 33:102 ( (Aug.) ) 1943.Crossref 32. Becks, H.; Simpson, M. E.; Li. C. H. and Evans, H. M.: Effects of Adrenocorticotropic Hormone (ACTH) on the Osseous System in Normal Rats , Endocrinology 34:305 ( (May) ) 1944.Crossref 33. Becks, H.; Simpson, M. E.; Marx, W. L.; Li, C. H., and Evans, H. M.: Antagonism of the Pituitary Adrenocorticotropic Hormone (ACTH) to the Action of Growth Hormone on the Osseous System of Hypophysectomized Rats , Endocrinology 34:311 ( (May) ) 1944.Crossref 34. Talbot, N. B., and Sobel, E. H.: Endocrine and Other Factors Determining the Growth of Children , in Advances in Pediatrics , edited by S. Z. Levine, A. M. Butler, L. E. Holt Jr., and A. A. Weech, New York, Interscience Publishers, Inc., 1947, Vol. 2, p. 238. 35. Griffiths, M., and Young, F. G.: Assay of Hypophyseal Growth-Promoting Extracts Employing Rats Treated with Diethylstilboestrol , J. Endocrinol. 3:96 ( (March) ) 1942.Crossref 36. Mulinos, M. G., and Pomerantz, L.: Pseudo-Hypophysectomy: A Condition Resembling Hypophysectomy Produced by Malnutrition , J. Nutrition 19:493 ( (May) ) 1940. 37. Ershoff, B. H.: Nutrition and the Anterior Pituitary with Special Reference to the General Adaptation Syndrome , Vitamins & Hormones 10:79, 1952. 38. Platt, R.: Renal Failure , Lancet 1:1239 ( (June 9) ) 1951. 39. McCance, R. A.: Excretion of Urea, Salts and Water During Periods of Hydropaenia in Man , J. Physiol. 104:196 ( (Oct. 15) ) 1945. 40. Rapoport, S.; Brodsky, W. A.; West, C. D., and Mackler, B.: Urinary Flow and Excretion of Solutes During Osmotic Diuresis in Hydropenic Man , Am. J. Physiol. 156:433 ( (March) ) 1949.
A.M.A. Journal of Diseases of Children – American Medical Association
Published: May 1, 1956
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