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AN ANAPHYLACTIC SKIN REACTION TO DIPHTHERIA BACILLI

AN ANAPHYLACTIC SKIN REACTION TO DIPHTHERIA BACILLI The intracutaneous toxin test of Schick for antitoxic immunity in diphtheria may be stated to have definitely established itself as a safe, easily applied and reliable practical test for detecting those persons who have sufficient natural diphtheria antitoxin in their body fluids to protect them against this infection and also as a measure of antitoxin production after active immunization with toxin-antitoxin mixtures, the latter being the original purpose of Schick in working out the technic of this test to replace the more expensive, time consuming and laborious procedure of determining the antitoxin content of a serum by means of injecting mixtures of the serum and a toxin into guinea-pigs. The positive toxin reaction is a localized inflammation excited by the unneutralized toxin in the skin, and in the majority of instances the area of erythema and edema is sufficiently well marked at the end of forty-eight hours to permit the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

AN ANAPHYLACTIC SKIN REACTION TO DIPHTHERIA BACILLI

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Publisher
American Medical Association
Copyright
Copyright © 1916 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1916.04110150114008
Publisher site
See Article on Publisher Site

Abstract

The intracutaneous toxin test of Schick for antitoxic immunity in diphtheria may be stated to have definitely established itself as a safe, easily applied and reliable practical test for detecting those persons who have sufficient natural diphtheria antitoxin in their body fluids to protect them against this infection and also as a measure of antitoxin production after active immunization with toxin-antitoxin mixtures, the latter being the original purpose of Schick in working out the technic of this test to replace the more expensive, time consuming and laborious procedure of determining the antitoxin content of a serum by means of injecting mixtures of the serum and a toxin into guinea-pigs. The positive toxin reaction is a localized inflammation excited by the unneutralized toxin in the skin, and in the majority of instances the area of erythema and edema is sufficiently well marked at the end of forty-eight hours to permit the

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Sep 1, 1916

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