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Abstract A recurrent sweat gland tumor of nodular syringocystadenoma type occurred in a 73-year-old man. The tumor showed mainly solid groups of uniform spindle-shaped cells with some central cystic changes. A considerable amount of amyloid was present in the tumor located in the epithelial nests and apparently being produced by them. To our knowledge no other comparable case of amyloid deposition in an adnexal skin tumor has been found in the literature. Amyloid may be deposited locally in other epithelial tumors not arising in the skin. The pathogenesis of the formation of amyloid in these tumors, and the present case may be similar, and dependent on a factor produced by the proliferating neoplastic cells reacting with a serum protein which results in the formation of amyloid material. This may occur on a simple chemical or immunochemical basis. References 1. Lund, H.Z.: " Tumors of the skin ," in Atlas of Tumor Pathology , Washington, DC: US Armed Forces Institute of Pathology, 1957. 2. Malak, J.A., and Smith, E.W.: Secondary Localised Cutaneous Amyloidosis , Arch Derm 86:465-477 ( (Oct) ) 1962.Crossref 3. Ganter, P., and Beurlet, J.: Le stroma amyloide des cancers cutanes baso-cellulaires , Ann Anat Path 10:233-247 ( (July) -Sept) 1965. 4. Teilum, G.: Amyloidosis: Origin From Fixed Periodic Acid-Schiff Positive Reticuloendothelial Cells in Loco and Basic Factors in Pathogenesis , Lab Invest 15:98-109 ( (Jan) ) 1966. 5. Williams, E.D.; Brown, C.L.; and Doniach, I.: Pathological and Clinical Findings in a Series of 67 Cases of Medullary Carcinoma of the Thyroid , J Clin Path 19:103-113 ( (March) ) 1966.Crossref 6. Hazard, J.B.; Hawk, W.A.; and Crile, G., Jr.: Medullary (Solid) Carcinoma of the Thyroid: A Clinicopathologic Entity , J Clin Endocr 19:152-161 ( (Jan) ) 1959.Crossref 7. Porta, E.A.; Yerry, R.; and Scott, R.F.: Amyloidosis of Functioning Islet Cell Adenomas of the Pancreas , Amer J Path 41:623-628 ( (Nov) ) 1962. 8. Vickers, R.A.; Dahlin, D.C.; and Gorlin, R.J.: Amyloid Containing Odontogenic Tumors , Oral Surg 20:476-480 ( (Oct) ) 1965.Crossref
Archives of Dermatology – American Medical Association
Published: Feb 1, 1970
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