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An Amyloid Forming Nodular Syringocystadenoma

An Amyloid Forming Nodular Syringocystadenoma Abstract A recurrent sweat gland tumor of nodular syringocystadenoma type occurred in a 73-year-old man. The tumor showed mainly solid groups of uniform spindle-shaped cells with some central cystic changes. A considerable amount of amyloid was present in the tumor located in the epithelial nests and apparently being produced by them. To our knowledge no other comparable case of amyloid deposition in an adnexal skin tumor has been found in the literature. Amyloid may be deposited locally in other epithelial tumors not arising in the skin. The pathogenesis of the formation of amyloid in these tumors, and the present case may be similar, and dependent on a factor produced by the proliferating neoplastic cells reacting with a serum protein which results in the formation of amyloid material. This may occur on a simple chemical or immunochemical basis. References 1. Lund, H.Z.: " Tumors of the skin ," in Atlas of Tumor Pathology , Washington, DC: US Armed Forces Institute of Pathology, 1957. 2. Malak, J.A., and Smith, E.W.: Secondary Localised Cutaneous Amyloidosis , Arch Derm 86:465-477 ( (Oct) ) 1962.Crossref 3. Ganter, P., and Beurlet, J.: Le stroma amyloide des cancers cutanes baso-cellulaires , Ann Anat Path 10:233-247 ( (July) -Sept) 1965. 4. Teilum, G.: Amyloidosis: Origin From Fixed Periodic Acid-Schiff Positive Reticuloendothelial Cells in Loco and Basic Factors in Pathogenesis , Lab Invest 15:98-109 ( (Jan) ) 1966. 5. Williams, E.D.; Brown, C.L.; and Doniach, I.: Pathological and Clinical Findings in a Series of 67 Cases of Medullary Carcinoma of the Thyroid , J Clin Path 19:103-113 ( (March) ) 1966.Crossref 6. Hazard, J.B.; Hawk, W.A.; and Crile, G., Jr.: Medullary (Solid) Carcinoma of the Thyroid: A Clinicopathologic Entity , J Clin Endocr 19:152-161 ( (Jan) ) 1959.Crossref 7. Porta, E.A.; Yerry, R.; and Scott, R.F.: Amyloidosis of Functioning Islet Cell Adenomas of the Pancreas , Amer J Path 41:623-628 ( (Nov) ) 1962. 8. Vickers, R.A.; Dahlin, D.C.; and Gorlin, R.J.: Amyloid Containing Odontogenic Tumors , Oral Surg 20:476-480 ( (Oct) ) 1965.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

An Amyloid Forming Nodular Syringocystadenoma

Jennings, Richard C.; Ahmed, Ejaz
Archives of Dermatology , Volume 101 (2) – Feb 1, 1970
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6 pages

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Publisher
American Medical Association
Copyright
Copyright © 1970 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1970.04000020094015
Publisher site
See Article on Publisher Site

Abstract

Abstract A recurrent sweat gland tumor of nodular syringocystadenoma type occurred in a 73-year-old man. The tumor showed mainly solid groups of uniform spindle-shaped cells with some central cystic changes. A considerable amount of amyloid was present in the tumor located in the epithelial nests and apparently being produced by them. To our knowledge no other comparable case of amyloid deposition in an adnexal skin tumor has been found in the literature. Amyloid may be deposited locally in other epithelial tumors not arising in the skin. The pathogenesis of the formation of amyloid in these tumors, and the present case may be similar, and dependent on a factor produced by the proliferating neoplastic cells reacting with a serum protein which results in the formation of amyloid material. This may occur on a simple chemical or immunochemical basis. References 1. Lund, H.Z.: " Tumors of the skin ," in Atlas of Tumor Pathology , Washington, DC: US Armed Forces Institute of Pathology, 1957. 2. Malak, J.A., and Smith, E.W.: Secondary Localised Cutaneous Amyloidosis , Arch Derm 86:465-477 ( (Oct) ) 1962.Crossref 3. Ganter, P., and Beurlet, J.: Le stroma amyloide des cancers cutanes baso-cellulaires , Ann Anat Path 10:233-247 ( (July) -Sept) 1965. 4. Teilum, G.: Amyloidosis: Origin From Fixed Periodic Acid-Schiff Positive Reticuloendothelial Cells in Loco and Basic Factors in Pathogenesis , Lab Invest 15:98-109 ( (Jan) ) 1966. 5. Williams, E.D.; Brown, C.L.; and Doniach, I.: Pathological and Clinical Findings in a Series of 67 Cases of Medullary Carcinoma of the Thyroid , J Clin Path 19:103-113 ( (March) ) 1966.Crossref 6. Hazard, J.B.; Hawk, W.A.; and Crile, G., Jr.: Medullary (Solid) Carcinoma of the Thyroid: A Clinicopathologic Entity , J Clin Endocr 19:152-161 ( (Jan) ) 1959.Crossref 7. Porta, E.A.; Yerry, R.; and Scott, R.F.: Amyloidosis of Functioning Islet Cell Adenomas of the Pancreas , Amer J Path 41:623-628 ( (Nov) ) 1962. 8. Vickers, R.A.; Dahlin, D.C.; and Gorlin, R.J.: Amyloid Containing Odontogenic Tumors , Oral Surg 20:476-480 ( (Oct) ) 1965.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Feb 1, 1970

References

  • Atlas of Tumor Pathology
    Lund , H.Z.: "
  • Secondary Localised Cutaneous Amyloidosis
    Malak , J.A., and Smith, E.W.
  • Le stroma amyloide des cancers cutanes baso-cellulaires
    Ganter , P., and Beurlet, J.
  • Amyloidosis: Origin From Fixed Periodic Acid-Schiff Positive Reticuloendothelial Cells in Loco and Basic Factors in Pathogenesis
    Teilum , G.
  • Pathological and Clinical Findings in a Series of 67 Cases of Medullary Carcinoma of the Thyroid
    Williams , E.D.; Brown, C.L.; and Doniach, I.
  • Medullary (Solid) Carcinoma of the Thyroid: A Clinicopathologic Entity
    Hazard , J.B.; Hawk, W.A.; and Crile, G., Jr.
  • Amyloidosis of Functioning Islet Cell Adenomas of the Pancreas
    Porta , E.A.; Yerry, R.; and Scott, R.F.
  • Amyloid Containing Odontogenic Tumors
    Vickers , R.A.; Dahlin, D.C.; and Gorlin, R.J.