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Amyopathic Dermatomyositis

Amyopathic Dermatomyositis Abstract DERMATOMYOSITIS IS a chronic inflammatory disorder involving skin and muscle; it may, in certain instances, be associated with pulmonary manifestations, cardiac involvement, and/or malignancy. It is commonly understood in this disorder, as in others, that not all manifestations need occur simultaneously, nor with the same degree of severity. In addition, some manifestations may be absent or have only minimal expression. In the case of its central features, however, controversy has arisen over incomplete disease presentation. Without rash, most authorities currently believe that the disease mechanisms and immunologic profile of polymyositis are so unique that this disorder should be set apart as a distinct nosologic entity. This suggestion largely rests on the character of the inflammatory infiltrate in muscle, as well as on certain clinical findings. Biopsy findings in dermatomyositis demonstrate the presence of an inflammatory infiltrate characterized by a T-lymphocytic response containing both See also page 1381 CD4 and CD8 References 1. Krain LS. Dermatomyositis in six patients without initial muscle involvement . Arch Dermatol. 1975;111:241-245.Crossref 2. Rockerbie NR, Woo TY, Callen JP, Giustina T. Cutaneous changes of dermatomyositis without muscle weakness . J Am Acad Dermatol. 1989;20:629-632.Crossref 3. Euwer R, Sontheimer RD. Amyopathic dermatomyositis (dermatomyositis sine myositis) . J Am Acad Dermatol. 1991;24:959-966.Crossref 4. Stonecipher MR, Jorizzo JL, White WL, Walker FO, Prichard E. Cutaneous changes of dermatomyositis in patients with normal enzymes: dermatomyositis sine myositis? J Am Acad Dermatol. 1993;28:951-956.Crossref 5. Cosnes A, Amaudric F, Gherardi R, et al. Dermatomyositis without muscle weakness: long-term follow-up of 12 patients without systemic corticosteroids . Arch Dermatol. 1995;131:1381-1385.Crossref 6. Braverman I. Connective tissue (rheumatic) diseases . In: Skin Signs of Systemic Disease. 2nd ed. Philadelphia, Pa: WB Saunders Co; 1981:300-310. 7. Bohan A, Peter JB, Bowman RL, Pearson CM. A computer-assisted analysis of 153 patients with polymyositis and dermatomyositis . Medicine. 1977;56:255-286.Crossref 8. Whitmore SE, Rosenshein NB, Provost TT. Ovarian cancer in patients with dermatomyositis . Medicine. 1994;73:153-160.Crossref 9. Sigurgiersson B, Lindelöf B, Edhag 0, Allander E. Risk of cancer in patients with dermatomyositis or polymyositis . N Engl J Med. 1992;326:363-367.Crossref 10. Callen JP, Hyla JF, Bole GG Jr, Kay DR. The relationship of dermatomyositis and polymyositis to internal malignancy . Arch Dermatol. 1980;116:295-298.Crossref 11. Schulman P, Kerr LD, Spiera H. A re-examination of the relationship between myositis and malignancy . J Rheumatol. 1991;18:1689-1692. 12. Koh ET, Seow A, Ong B, Ratnagopal P, Tjia H, Chung HH. Adult onset polymyositis/ dermatomyositis: clinical and laboratory features and treatment response in 75 patients . Ann Rheum Dis. 1993;52:857-861.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Amyopathic Dermatomyositis

Archives of Dermatology , Volume 131 (12) – Dec 1, 1995

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Publisher
American Medical Association
Copyright
Copyright © 1995 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1995.01690240124023
Publisher site
See Article on Publisher Site

Abstract

Abstract DERMATOMYOSITIS IS a chronic inflammatory disorder involving skin and muscle; it may, in certain instances, be associated with pulmonary manifestations, cardiac involvement, and/or malignancy. It is commonly understood in this disorder, as in others, that not all manifestations need occur simultaneously, nor with the same degree of severity. In addition, some manifestations may be absent or have only minimal expression. In the case of its central features, however, controversy has arisen over incomplete disease presentation. Without rash, most authorities currently believe that the disease mechanisms and immunologic profile of polymyositis are so unique that this disorder should be set apart as a distinct nosologic entity. This suggestion largely rests on the character of the inflammatory infiltrate in muscle, as well as on certain clinical findings. Biopsy findings in dermatomyositis demonstrate the presence of an inflammatory infiltrate characterized by a T-lymphocytic response containing both See also page 1381 CD4 and CD8 References 1. Krain LS. Dermatomyositis in six patients without initial muscle involvement . Arch Dermatol. 1975;111:241-245.Crossref 2. Rockerbie NR, Woo TY, Callen JP, Giustina T. Cutaneous changes of dermatomyositis without muscle weakness . J Am Acad Dermatol. 1989;20:629-632.Crossref 3. Euwer R, Sontheimer RD. Amyopathic dermatomyositis (dermatomyositis sine myositis) . J Am Acad Dermatol. 1991;24:959-966.Crossref 4. Stonecipher MR, Jorizzo JL, White WL, Walker FO, Prichard E. Cutaneous changes of dermatomyositis in patients with normal enzymes: dermatomyositis sine myositis? J Am Acad Dermatol. 1993;28:951-956.Crossref 5. Cosnes A, Amaudric F, Gherardi R, et al. Dermatomyositis without muscle weakness: long-term follow-up of 12 patients without systemic corticosteroids . Arch Dermatol. 1995;131:1381-1385.Crossref 6. Braverman I. Connective tissue (rheumatic) diseases . In: Skin Signs of Systemic Disease. 2nd ed. Philadelphia, Pa: WB Saunders Co; 1981:300-310. 7. Bohan A, Peter JB, Bowman RL, Pearson CM. A computer-assisted analysis of 153 patients with polymyositis and dermatomyositis . Medicine. 1977;56:255-286.Crossref 8. Whitmore SE, Rosenshein NB, Provost TT. Ovarian cancer in patients with dermatomyositis . Medicine. 1994;73:153-160.Crossref 9. Sigurgiersson B, Lindelöf B, Edhag 0, Allander E. Risk of cancer in patients with dermatomyositis or polymyositis . N Engl J Med. 1992;326:363-367.Crossref 10. Callen JP, Hyla JF, Bole GG Jr, Kay DR. The relationship of dermatomyositis and polymyositis to internal malignancy . Arch Dermatol. 1980;116:295-298.Crossref 11. Schulman P, Kerr LD, Spiera H. A re-examination of the relationship between myositis and malignancy . J Rheumatol. 1991;18:1689-1692. 12. Koh ET, Seow A, Ong B, Ratnagopal P, Tjia H, Chung HH. Adult onset polymyositis/ dermatomyositis: clinical and laboratory features and treatment response in 75 patients . Ann Rheum Dis. 1993;52:857-861.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Dec 1, 1995

References