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Amyloidosis of the Head and Neck: A Clinicopathologic Study of the UCLA Experience, 1955-1991

Amyloidosis of the Head and Neck: A Clinicopathologic Study of the UCLA Experience, 1955-1991 Abstract Objective: To characterize the otolaryngologic manifestations of amyloidosis; classify patients with amyloidosis by specific location and type of underlying disease; and compare disease presentation and long-term outcome in these patients. Design: Retrospective review of biopsy specimens recorded as amyloidosis. Setting: Tertiary care referral center serving a diverse patient base. Patients: Of 141 patients with biopsy-verified amyloidosis who met the inclusion criterion for the study, 27 (19%) had head and neck manifestations. Outcome Measures: Good functional outcome and survival of patients with amyloidosis. Results: The tongue was the most commonly affected site of the head and neck. Distinct differences exist in functional outcome and long-term survival in patients with the localized form of amyloidosis when compared with patients with systemic amyloidosis. Conclusion: Because amyloidosis often affects the head and neck, otolaryngologists need to be familiar with this disease.(Arch Otolaryngol Head Neck Surg. 1995;121:778-782) References 1. Kyle RA, Bayrd ED. Amyloidosis: review of 236 cases . Medicine . 1975;54:271-299.Crossref 2. Briggs GW. Amyloidosis . Ann Intern Med . 1961;55:943-957.Crossref 3. Symmers W. Primary amyloidosis: a review . J Clin Pathol . 1956;9:187-211.Crossref 4. Chen KTK. Amyloidosis presenting in the respiratory tract . Pathol Annu . 1989; 24( (pt 1) ):253-273. 5. Lewis JE, Olsen KD, Kurtin PJ, et al. Laryngeal amyloidosis: a clinicopathologic and immunohistochemical review . Otolaryngol Head Neck Surg . 1992; 106:372-377. 6. Simpson GT, Strong MS, Skinner M, et al. Localized amyloidosis of the head and neck and upper aerodigestive and lower respiratory tracts . Ann Otol Rhinol Laryngol . 1984;93:374-379. 7. Michaels L, Hyams VJ. Amyloid in localised deposits and plasmacytomas of the respiratory tract . J Pathol . 1979;128:29-38.Crossref 8. Dendy RA, Davies JR, Gorst DW. A tongue resection in macroglossia due to primary amyloidosis . Br J Oral Maxillofac Surg . 1989;27:329-333.Crossref 9. Gertz MA, Kyle RA. Primary systemic amyloidosis: a diagnostic primer . Mayo Clin Proc . 1989;64:1505-1519.Crossref 10. Hawkins PN, Lavender JP, Pepys MB. Evaluation of systemic amyloidosis by scintigraphy with 123l-labeled serum amyloid P component . N Engl J Med . 1990; 323:508-513.Crossref 11. Hellquist H, Sokjer H, Odkvist LM. Amyloidosis of the larynx . Acta Otolaryngol (Stockh) . 1979;88:443-450.Crossref 12. Barnes EL, Zafar T. Laryngeal amyloidosis: clinicopathologic study of seven cases . Ann Otol Rhinol Laryngol . 1977;86:856-863. 13. Hardingham M. Diffuse amyloidosis of the larynx . Ear Nose Throat J . 1987; 66:32-38. 14. Timosca G, Gavrilita L. Primary localized amyloidosis of the palate . Oral Surg Oral Med Oral Pathol 1977;44:76-83.Crossref 15. Beiser M, Messer G, Samuel J, et al. Amyloidosis of Waldeyer's ring . Acta Otolaryngol (Stockh) . 1980;89:562-569.Crossref 16. Pizov G, Soffer D. Amyloid tumor (amyloidoma) of a peripheral nerve . Arch Pathol Lab Med . 1986;110:969-970. 17. Kerr PD, Dort JC. Primary extramedullary plasmacytoma of the salivary glands . J Laryngol Otol . 1991;105:687-692.Crossref 18. Westermark P, Stenkvist B. A new method for the diagnosis of systemic amyloidosis . Arch Intern Med . 1973;182:522-523.Crossref 19. Kerr PD, Dort JC. Primary extramedullary plasmacytoma of the salivary glands . J Laryngol Otol . 1991;105:687-692.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology - Head & Neck Surgery American Medical Association

Amyloidosis of the Head and Neck: A Clinicopathologic Study of the UCLA Experience, 1955-1991

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Publisher
American Medical Association
Copyright
Copyright © 1995 American Medical Association. All Rights Reserved.
ISSN
0886-4470
eISSN
1538-361X
DOI
10.1001/archotol.1995.01890070064014
Publisher site
See Article on Publisher Site

Abstract

Abstract Objective: To characterize the otolaryngologic manifestations of amyloidosis; classify patients with amyloidosis by specific location and type of underlying disease; and compare disease presentation and long-term outcome in these patients. Design: Retrospective review of biopsy specimens recorded as amyloidosis. Setting: Tertiary care referral center serving a diverse patient base. Patients: Of 141 patients with biopsy-verified amyloidosis who met the inclusion criterion for the study, 27 (19%) had head and neck manifestations. Outcome Measures: Good functional outcome and survival of patients with amyloidosis. Results: The tongue was the most commonly affected site of the head and neck. Distinct differences exist in functional outcome and long-term survival in patients with the localized form of amyloidosis when compared with patients with systemic amyloidosis. Conclusion: Because amyloidosis often affects the head and neck, otolaryngologists need to be familiar with this disease.(Arch Otolaryngol Head Neck Surg. 1995;121:778-782) References 1. Kyle RA, Bayrd ED. Amyloidosis: review of 236 cases . Medicine . 1975;54:271-299.Crossref 2. Briggs GW. Amyloidosis . Ann Intern Med . 1961;55:943-957.Crossref 3. Symmers W. Primary amyloidosis: a review . J Clin Pathol . 1956;9:187-211.Crossref 4. Chen KTK. Amyloidosis presenting in the respiratory tract . Pathol Annu . 1989; 24( (pt 1) ):253-273. 5. Lewis JE, Olsen KD, Kurtin PJ, et al. Laryngeal amyloidosis: a clinicopathologic and immunohistochemical review . Otolaryngol Head Neck Surg . 1992; 106:372-377. 6. Simpson GT, Strong MS, Skinner M, et al. Localized amyloidosis of the head and neck and upper aerodigestive and lower respiratory tracts . Ann Otol Rhinol Laryngol . 1984;93:374-379. 7. Michaels L, Hyams VJ. Amyloid in localised deposits and plasmacytomas of the respiratory tract . J Pathol . 1979;128:29-38.Crossref 8. Dendy RA, Davies JR, Gorst DW. A tongue resection in macroglossia due to primary amyloidosis . Br J Oral Maxillofac Surg . 1989;27:329-333.Crossref 9. Gertz MA, Kyle RA. Primary systemic amyloidosis: a diagnostic primer . Mayo Clin Proc . 1989;64:1505-1519.Crossref 10. Hawkins PN, Lavender JP, Pepys MB. Evaluation of systemic amyloidosis by scintigraphy with 123l-labeled serum amyloid P component . N Engl J Med . 1990; 323:508-513.Crossref 11. Hellquist H, Sokjer H, Odkvist LM. Amyloidosis of the larynx . Acta Otolaryngol (Stockh) . 1979;88:443-450.Crossref 12. Barnes EL, Zafar T. Laryngeal amyloidosis: clinicopathologic study of seven cases . Ann Otol Rhinol Laryngol . 1977;86:856-863. 13. Hardingham M. Diffuse amyloidosis of the larynx . Ear Nose Throat J . 1987; 66:32-38. 14. Timosca G, Gavrilita L. Primary localized amyloidosis of the palate . Oral Surg Oral Med Oral Pathol 1977;44:76-83.Crossref 15. Beiser M, Messer G, Samuel J, et al. Amyloidosis of Waldeyer's ring . Acta Otolaryngol (Stockh) . 1980;89:562-569.Crossref 16. Pizov G, Soffer D. Amyloid tumor (amyloidoma) of a peripheral nerve . Arch Pathol Lab Med . 1986;110:969-970. 17. Kerr PD, Dort JC. Primary extramedullary plasmacytoma of the salivary glands . J Laryngol Otol . 1991;105:687-692.Crossref 18. Westermark P, Stenkvist B. A new method for the diagnosis of systemic amyloidosis . Arch Intern Med . 1973;182:522-523.Crossref 19. Kerr PD, Dort JC. Primary extramedullary plasmacytoma of the salivary glands . J Laryngol Otol . 1991;105:687-692.Crossref

Journal

Archives of Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: Jul 1, 1995

References