ORIGINAL CONTRIBUTION Scan for Author Video Interview A Randomized Controlled Trial Jane M. Garbutt, MBChB Context Evidence to support antibiotic treatment for acute rhinosinusitis is limited, yet antibiotics are commonly used. Christina Banister, BA Edward Spitznagel, PhD Objective To determine the incremental effect of amoxicillin treatment over symp- tomatic treatments for adults with clinically diagnosed acute rhinosinusitis. Jay F. Piccirillo, MD Design, Setting, and Participants A randomized, placebo-controlled trial of adults CUTE RHINOSINUSITIS IS A with uncomplicated, acute rhinosinusitis were recruited from 10 community practices common disease associated in Missouri between November 1, 2006, and May 1, 2009. with significant morbidity, Interventions Ten-day course of either amoxicillin (1500 mg/d) or placebo admin- Alost time from work, and istered in 3 doses per day. All patients received a 5- to 7-day supply of symptomatic 1,2 treatment costs. Considering the treatments for pain, fever, cough, and nasal congestion to use as needed. public health threat posed by increas- Main Outcome Measures The primary outcome was improvement in disease- ing antibiotic resistance, strong evi- specific quality of life after 3 to 4 days of treatment assessed with the Sinonasal Out- dence of symptom relief is needed to come Test-16 (minimally important difference
JAMA – American Medical Association
Published: Feb 15, 2012
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