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Amoxicillin for Acute Rhinosinusitis

Amoxicillin for Acute Rhinosinusitis ORIGINAL CONTRIBUTION Scan for Author Video Interview A Randomized Controlled Trial Jane M. Garbutt, MBChB Context Evidence to support antibiotic treatment for acute rhinosinusitis is limited, yet antibiotics are commonly used. Christina Banister, BA Edward Spitznagel, PhD Objective To determine the incremental effect of amoxicillin treatment over symp- tomatic treatments for adults with clinically diagnosed acute rhinosinusitis. Jay F. Piccirillo, MD Design, Setting, and Participants A randomized, placebo-controlled trial of adults CUTE RHINOSINUSITIS IS A with uncomplicated, acute rhinosinusitis were recruited from 10 community practices common disease associated in Missouri between November 1, 2006, and May 1, 2009. with significant morbidity, Interventions Ten-day course of either amoxicillin (1500 mg/d) or placebo admin- Alost time from work, and istered in 3 doses per day. All patients received a 5- to 7-day supply of symptomatic 1,2 treatment costs. Considering the treatments for pain, fever, cough, and nasal congestion to use as needed. public health threat posed by increas- Main Outcome Measures The primary outcome was improvement in disease- ing antibiotic resistance, strong evi- specific quality of life after 3 to 4 days of treatment assessed with the Sinonasal Out- dence of symptom relief is needed to come Test-16 (minimally important difference http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Amoxicillin for Acute Rhinosinusitis

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Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2012.138
pmid
22337680
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Scan for Author Video Interview A Randomized Controlled Trial Jane M. Garbutt, MBChB Context Evidence to support antibiotic treatment for acute rhinosinusitis is limited, yet antibiotics are commonly used. Christina Banister, BA Edward Spitznagel, PhD Objective To determine the incremental effect of amoxicillin treatment over symp- tomatic treatments for adults with clinically diagnosed acute rhinosinusitis. Jay F. Piccirillo, MD Design, Setting, and Participants A randomized, placebo-controlled trial of adults CUTE RHINOSINUSITIS IS A with uncomplicated, acute rhinosinusitis were recruited from 10 community practices common disease associated in Missouri between November 1, 2006, and May 1, 2009. with significant morbidity, Interventions Ten-day course of either amoxicillin (1500 mg/d) or placebo admin- Alost time from work, and istered in 3 doses per day. All patients received a 5- to 7-day supply of symptomatic 1,2 treatment costs. Considering the treatments for pain, fever, cough, and nasal congestion to use as needed. public health threat posed by increas- Main Outcome Measures The primary outcome was improvement in disease- ing antibiotic resistance, strong evi- specific quality of life after 3 to 4 days of treatment assessed with the Sinonasal Out- dence of symptom relief is needed to come Test-16 (minimally important difference

Journal

JAMAAmerican Medical Association

Published: Feb 15, 2012

References