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References (8)
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R. Frank, U. Salmon, R. Friedman (1935)
Determination of Luteinizing and Follicle-Stimulating Principles in Castrate and Menopause UrineProceedings of the Society for Experimental Biology and Medicine, 32
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B. Zondek (1931)
Die Hormone des Ovariums und des Hypophysenvorderlappens: Untersuchungen zur Biologie und Klinik der Weiblichen Genitalfunktion -
R. Frank (1931)
THE RÔLE OF THE FEMALE SEX HORMONEJAMA, 97
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E. Allen (1928)
Further experiments with an ovarian hormone in the ovariectomized adult monkey, macacus rhesus, especially the degenerative phase of the experimental menstrual cycleAmerican Journal of Anatomy, 42
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H. Mazer, S. Israel (1937)
STUDIES ON THE OPTIMAL DOSAGE OF ESTROGENS: AN EXPERIMENTAL AND CLINICAL EVALUATIONJAMA, 108
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R. Frank, M. Goldberger, U. Salmon (1936)
Estrogenic Substances in the Blood and Urine After Castration and the MenopauseProceedings of the Society for Experimental Biology and Medicine, 33
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R. Frank (1935)
SEX-ENDOCRINE FACTORS IN BLOOD AND URINE IN HEALTH AND DISEASEJAMA, 104
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U. Salmon, R. Frank (1935)
An Improved Method for Determination of the Gonadotropic HormoneProceedings of the Society for Experimental Biology and Medicine, 32
- Publisher
- American Medical Association
- Copyright
- Copyright © 1937 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
- ISSN
- 0098-7484
- eISSN
- 1538-3598
- DOI
- 10.1001/jama.1937.02780490001001
- Publisher site
- See Article on Publisher Site
Abstract
This investigation of patients with amenorrhea is a continuation of our studies on oligomenorrhea, amenorrhea and sterility begun in 1931.1 Since our last publications the methods for determining the gonadotropic factors in both blood and urine have been improved.2 As far as treatment is concerned, pure estrogenic substances are now available in large dosage. In addition to gonadotropic substances from pregnancy urine or the placenta, which lack some of the properties of the adenohypophysis, physiologically potent gland preparations and their equivalent—the serum of pregnant mares—are now available. This permits a better evaluation of any prepituitary effects that might be obtained in our carefully controlled series of cases. MATERIAL The patients selected had suffered with amenorrhea for various periods and were of various ages. Intelligence, faithful carrying out of orders, ability and willingness to report as directed were of importance in the choice. In one instance the investigation covered
Journal
JAMA – American Medical Association
Published: Dec 4, 1937