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Alternating Electric Fields for the Treatment of Glioblastoma

Alternating Electric Fields for the Treatment of Glioblastoma Opinion Editorials represent the opinions of the authors and JAMA EDITORIAL and not those of the American Medical Association. John H. Sampson, MD, PhD, MHSc, MBA Glioblastoma is the most common malignant tumor of the cen- expected from a locally delivered therapy, the delivery of AEFs tral nervous system, and one of the most difficult cancers to was not associated with any significant increase in systemic treat. Standard therapy includes maximal surgical resection, toxic effects, though there was a higher incidence of scalp ir- high-dose external-beam ra- ritation, anxiety, confusion, insomnia, and headaches. The diation therapy, and regional incidence of seizures was not increased. Author Audio Interview at or systemic chemotherapy. It has been hypothesized that the polarity of AEFs at spe- jama.com Still, 5-year survival rates are cific frequencies can disrupt spindle formation during cell di- only 5%. Current therapies vision and lead to mitotic arrest. When AEFs are applied to hu- lack specificity, fail to address man and rodent cancer cell lines in vitro using insulated wires Related article page 2535 tumor heterogeneity, or are fixed to the bottom of standard cell culture dishes, there was limited because of an inability to penetrate the blood-brain bar- a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Alternating Electric Fields for the Treatment of Glioblastoma

JAMA , Volume 314 (23) – Dec 15, 2015

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Publisher
American Medical Association
Copyright
Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2015.16701
pmid
26670969
Publisher site
See Article on Publisher Site

Abstract

Opinion Editorials represent the opinions of the authors and JAMA EDITORIAL and not those of the American Medical Association. John H. Sampson, MD, PhD, MHSc, MBA Glioblastoma is the most common malignant tumor of the cen- expected from a locally delivered therapy, the delivery of AEFs tral nervous system, and one of the most difficult cancers to was not associated with any significant increase in systemic treat. Standard therapy includes maximal surgical resection, toxic effects, though there was a higher incidence of scalp ir- high-dose external-beam ra- ritation, anxiety, confusion, insomnia, and headaches. The diation therapy, and regional incidence of seizures was not increased. Author Audio Interview at or systemic chemotherapy. It has been hypothesized that the polarity of AEFs at spe- jama.com Still, 5-year survival rates are cific frequencies can disrupt spindle formation during cell di- only 5%. Current therapies vision and lead to mitotic arrest. When AEFs are applied to hu- lack specificity, fail to address man and rodent cancer cell lines in vitro using insulated wires Related article page 2535 tumor heterogeneity, or are fixed to the bottom of standard cell culture dishes, there was limited because of an inability to penetrate the blood-brain bar- a

Journal

JAMAAmerican Medical Association

Published: Dec 15, 2015

References