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Alterations in Kinins of Coronary Blood From Rat Heart Homografts

Alterations in Kinins of Coronary Blood From Rat Heart Homografts Abstract Forty-eight heterotopic heart transplants (33 homografts and 15 isografts) were performed in inbred rats. Levels of kallikrein, prekallikrein, and kallikrein inhibitor were determined in coronary sinus venous blood of grafted hearts at various intervals postgrafting. Homograft observations were assessed against those in nonrejecting isografts. Significant increases in homograft prekallikrein level on day 4 were followed by significant increases in homograft kallikrein activity on day 6. Kallikrein inhibitor levels in homografts were consistently increased in relation to isograft levels. Kallikrein and inhibitor activity showed an inverse relationship in their respective changes. High levels of kallikrein and prekallikrein occurred in homografts ten days posttransplantation. Immunological rejecting homografts showed meaningful changes in the activity of kinin-forming substances known to participate in inflammation. References 1. Moore TC, Chang J: Urinary histamine excretion in the rat following skin homografting and autografting . Ann Surg 167:232-238, 1968.Crossref 2. Moore TC, Cleveland RJ, Thompson DP, et al: Vasoactive amine metabolism following canine and human heart transplantation . Ann Surg 174:51-57, 1971.Crossref 3. Moore TC, Thompson DP, Glassock RJ: Elevation in urinary and blood histamine following clinical renal transplantation . Ann Surg 173:381-388, 1971.Crossref 4. Moore TC, Lemmi CAE, Orlando JC, et al: Correlation of splenic histidine decarboxylase activity and antibody formation following SRBC immunization . Transplantation 11:347-348, 1971. 5. Moore TC, Schayer RW: Histidine decarboxylase activity of the rat spleen following skin allografting . Ann Surg 171:609-614, 1970.Crossref 6. Moore TC, Schayer RW: Histidine decarboxylase activity of autografted and allografted rat skin . Transplantation 7:99-104, 1969.Crossref 7. Moore TC, Thompson DP, Hayes M: Correlation of renal blood-flow indices and histamine metabolism after canine renal allografting . Arch Surg 101:45-51, 1970.Crossref 8. Moore TC: Histidine decarboxylase inhibitors and the survival of skin homografts . Nature 215:871-872, 1967.Crossref 9. Moore TC: Histidine decarboxylase inhibitors and second-set allograft survival . Arch Surg 99:470-473, 1969.Crossref 10. Moore TC, Lawrence W Jr: Suppression of antibody formation by histidine decarboxylase inhibitors . Transplantation 8:224-234, 1969.Crossref 11. Cochrane CG, Wuepper KO: The first component of the kinin-forming system in human and rabbit plasma: Its relation to clotting factor XII (Hageman factor) . J Exp Med 134:986-1004, 1971.Crossref 12. Kaplan AP, Austen KR: A prealbumin activator of prekallikrein: II. Derivation of activators of prekallikrein from active Hageman factor by digestion with plasmin . J Exp Med 133:696-712, 1971.Crossref 13. Rocha e Silva M: Present trends of kinin research . Life Sci 15:7-22, 1974.Crossref 14. Ono K, Lindsey E: Improved technique of heart transplantation in rats . J Thorac Cardiovasc Surg 2:225-229, 1969. 15. Abbott CP, Lindsey ES, Creech O Jr, et al: A technique for heart transplantation in the rat . Arch Surg 89:645-652, 1964.Crossref 16. Colman RW, Mason JW, Sherry S: The kallikreinogen-kallikrein enzyme system of human plasma . Ann Intern Med 71:763-773, 1969.Crossref 17. Miller RL, Melmon KL: The related roles of histamine, serotonin, and bradykinin in the pathogenesis of inflammation . Ser Haematol 3:5-38, 1970. 18. Moore TC: Role of vasoactive substances in the afferent and efferent arcs of the immune response . IRCS Med Sci 2:46-51, 1974. 19. Cochrane CG, Revak SD, Wuepper KD: Activation of Hageman factor in solid and fluid phase: A critical role of kallikrein . J Exp Med 138:1564-1583, 1973.Crossref 20. Bagdasarian A, Lahiri B, Colman RW: Origin of the high molecular weight activator of prekallikrein . J Biol Chem 248:7742-7747, 1973. 21. Moore TC, Sinclair MC, Lemmi CAE: Elevation in plasma kallikrein activity after rat kidney allografting . Am J Surg 127:287-291, 1971.Crossref 22. Geipert F, Erdos EG: Properties of granules that contain kallikrein and renin . Experientia 27:912-913, 1971.Crossref 23. MacFarlane NA, Adetvyibi A, Mills IH: Proceedings: Changes in kallikrein excretion during arterial infusion of angiotensin . N Engl J Med 291:72, 1974. 24. Margolins HS, Geller RG, de Jong W, et al: Altered urinary kallikrein excretion in rats with hypertension . Circ Res 30:358-362, 1972.Crossref 25. Margolins HS, Geller RG, de Jong W, et al: Urinary kallikrein excretion in hypertension . Circ Res 31:125-131, 1972.Crossref 26. Croxatto HR, San Martin M: Kallikrein-like activity in the urine of renal hypertensive rats . Experientia 26:1216-1217, 1970.Crossref 27. Aaron RK: Reduction of Hageman factor prekallikrein and kininogen in surgical stress. Read before the International Conference on Chemistry and Biology of the Kallikrein-Kinin System in Health and Disease, Reston, Va, 1974. 28. Werle E, Schmall A: Bradykinin, Kallidin, and Kallikrein: Handbook of Experimental Pharmacology . EG Erdos (ed), Berlin, Springer-Verlag, 1970, vol 25. 29. Abbott CP, DeWitt CW, Creech O Jr: The transplanted rat heart: Histologic and electrocardiographic changes . Transplantation 3:432-445, 1965.Crossref 30. McGregor DD, Logie PS: The mediator of cellular immunology: VII. Localization of sensitized lymphocytes in inflammatory exudates . J Exp Med 139:1415-1430, 1974.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Alterations in Kinins of Coronary Blood From Rat Heart Homografts

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Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1975.01360150014002
Publisher site
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Abstract

Abstract Forty-eight heterotopic heart transplants (33 homografts and 15 isografts) were performed in inbred rats. Levels of kallikrein, prekallikrein, and kallikrein inhibitor were determined in coronary sinus venous blood of grafted hearts at various intervals postgrafting. Homograft observations were assessed against those in nonrejecting isografts. Significant increases in homograft prekallikrein level on day 4 were followed by significant increases in homograft kallikrein activity on day 6. Kallikrein inhibitor levels in homografts were consistently increased in relation to isograft levels. Kallikrein and inhibitor activity showed an inverse relationship in their respective changes. High levels of kallikrein and prekallikrein occurred in homografts ten days posttransplantation. Immunological rejecting homografts showed meaningful changes in the activity of kinin-forming substances known to participate in inflammation. References 1. Moore TC, Chang J: Urinary histamine excretion in the rat following skin homografting and autografting . Ann Surg 167:232-238, 1968.Crossref 2. Moore TC, Cleveland RJ, Thompson DP, et al: Vasoactive amine metabolism following canine and human heart transplantation . Ann Surg 174:51-57, 1971.Crossref 3. Moore TC, Thompson DP, Glassock RJ: Elevation in urinary and blood histamine following clinical renal transplantation . Ann Surg 173:381-388, 1971.Crossref 4. Moore TC, Lemmi CAE, Orlando JC, et al: Correlation of splenic histidine decarboxylase activity and antibody formation following SRBC immunization . Transplantation 11:347-348, 1971. 5. Moore TC, Schayer RW: Histidine decarboxylase activity of the rat spleen following skin allografting . Ann Surg 171:609-614, 1970.Crossref 6. Moore TC, Schayer RW: Histidine decarboxylase activity of autografted and allografted rat skin . Transplantation 7:99-104, 1969.Crossref 7. Moore TC, Thompson DP, Hayes M: Correlation of renal blood-flow indices and histamine metabolism after canine renal allografting . Arch Surg 101:45-51, 1970.Crossref 8. Moore TC: Histidine decarboxylase inhibitors and the survival of skin homografts . Nature 215:871-872, 1967.Crossref 9. Moore TC: Histidine decarboxylase inhibitors and second-set allograft survival . Arch Surg 99:470-473, 1969.Crossref 10. Moore TC, Lawrence W Jr: Suppression of antibody formation by histidine decarboxylase inhibitors . Transplantation 8:224-234, 1969.Crossref 11. Cochrane CG, Wuepper KO: The first component of the kinin-forming system in human and rabbit plasma: Its relation to clotting factor XII (Hageman factor) . J Exp Med 134:986-1004, 1971.Crossref 12. Kaplan AP, Austen KR: A prealbumin activator of prekallikrein: II. Derivation of activators of prekallikrein from active Hageman factor by digestion with plasmin . J Exp Med 133:696-712, 1971.Crossref 13. Rocha e Silva M: Present trends of kinin research . Life Sci 15:7-22, 1974.Crossref 14. Ono K, Lindsey E: Improved technique of heart transplantation in rats . J Thorac Cardiovasc Surg 2:225-229, 1969. 15. Abbott CP, Lindsey ES, Creech O Jr, et al: A technique for heart transplantation in the rat . Arch Surg 89:645-652, 1964.Crossref 16. Colman RW, Mason JW, Sherry S: The kallikreinogen-kallikrein enzyme system of human plasma . Ann Intern Med 71:763-773, 1969.Crossref 17. Miller RL, Melmon KL: The related roles of histamine, serotonin, and bradykinin in the pathogenesis of inflammation . Ser Haematol 3:5-38, 1970. 18. Moore TC: Role of vasoactive substances in the afferent and efferent arcs of the immune response . IRCS Med Sci 2:46-51, 1974. 19. Cochrane CG, Revak SD, Wuepper KD: Activation of Hageman factor in solid and fluid phase: A critical role of kallikrein . J Exp Med 138:1564-1583, 1973.Crossref 20. Bagdasarian A, Lahiri B, Colman RW: Origin of the high molecular weight activator of prekallikrein . J Biol Chem 248:7742-7747, 1973. 21. Moore TC, Sinclair MC, Lemmi CAE: Elevation in plasma kallikrein activity after rat kidney allografting . Am J Surg 127:287-291, 1971.Crossref 22. Geipert F, Erdos EG: Properties of granules that contain kallikrein and renin . Experientia 27:912-913, 1971.Crossref 23. MacFarlane NA, Adetvyibi A, Mills IH: Proceedings: Changes in kallikrein excretion during arterial infusion of angiotensin . N Engl J Med 291:72, 1974. 24. Margolins HS, Geller RG, de Jong W, et al: Altered urinary kallikrein excretion in rats with hypertension . Circ Res 30:358-362, 1972.Crossref 25. Margolins HS, Geller RG, de Jong W, et al: Urinary kallikrein excretion in hypertension . Circ Res 31:125-131, 1972.Crossref 26. Croxatto HR, San Martin M: Kallikrein-like activity in the urine of renal hypertensive rats . Experientia 26:1216-1217, 1970.Crossref 27. Aaron RK: Reduction of Hageman factor prekallikrein and kininogen in surgical stress. Read before the International Conference on Chemistry and Biology of the Kallikrein-Kinin System in Health and Disease, Reston, Va, 1974. 28. Werle E, Schmall A: Bradykinin, Kallidin, and Kallikrein: Handbook of Experimental Pharmacology . EG Erdos (ed), Berlin, Springer-Verlag, 1970, vol 25. 29. Abbott CP, DeWitt CW, Creech O Jr: The transplanted rat heart: Histologic and electrocardiographic changes . Transplantation 3:432-445, 1965.Crossref 30. McGregor DD, Logie PS: The mediator of cellular immunology: VII. Localization of sensitized lymphocytes in inflammatory exudates . J Exp Med 139:1415-1430, 1974.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Sep 1, 1975

References