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Allergic Photocontact Dermatitis from Promethazine (Phenergan)

Allergic Photocontact Dermatitis from Promethazine (Phenergan) Abstract Allergic photocontact dermatitis from promethazine (Phenergan) seems to be rare in this country. The following case is presented mainly because the allergic nature of the dermatitis appears well documented. Report of a Case A male white bartender, 33 years of age, was seen on Aug. 21, 1958. He suffered from a dermatitis of the hands for about six weeks, apparently due to contacts in his occupation and infection. He had been treated with various ointments, among them promethazine cream. Two days prior to his first visit he again had applied promethazine cream and accidentally had exposed his hands to sunlight. A hyperacute dermatitis followed with swelling and large blisters on the dorsa of both hands, spreading beyond the area involved by the underlying chronic eczema.The acute photocontact dermatitis subsided quickly, but the original "bartender's eczema" persisted with aggravations when he exposed himself to the cleaning and antiseptic solutions of References 1. Controls with these patch and photopatch tests on normal persons were always negative. Long ultraviolet was applied by five minutes of irradiation with filtered (Corning filter No. 597) light from a Kromayer lamp. This light never produces a reaction on normal persons even with four times the time used in the tests. 2. Dr. Hermann Pinkus, Monroe, Mich., did the interpretation and photomicrographs of the biopsy specimens. 3. Burckhardt, W.: Untersuchungen über die Photoaktivität einiger Sulfanilamide , Dermatologica 83:63, 1941.Crossref 4. Burckhardt, W.: Photoallergische Ekzeme durch Sulfanilamidsalben , Dermatologica 96:280-285, 1948.Crossref 5. Epstein, S.: Photoallergy and Primary Phototoxicity to Sulfanilamide , J. Invest. Dermat. 2:43-51, 1939.Crossref 6. Calnan, C. D.: Drug Photosensitivity with Chlorpromazine , Tr. St. John's Hosp. Dermat. Soc. , to be published. 7. Sidi, E.: Les Photosensibilisations spontanées et provoquées , Vie méd. 39:875-884, 1958. 8. Sidi, E.; Hincky, M., and Gervais, A.: Allergic Sensitization and Photosensitization to Phenergan Cream , J. Invest. Dermat. 24:345-352, 1955.Crossref 9. Ippen, H.: Zur Spezifität der Photoallergie, 1958, to be published. 10. Schulz, K. H.; Wiskemann, A., and Wulf, K.: Klinische und experimentelle Untersuchungen über die photodynamische Wirksamkeit von Phenothiazinderivaten, insbesondere von Megaphen , Arch. klin. u. exper. Dermat. 202:285-298, 1956.Crossref 11. Epstein, S., and Rowe, R.: Photoallergy and Photocross-Sensitivity to Phenergan , J. Invest. Dermat. 29:319-326, 1957.Crossref 12. Cahn, M. M., and Levy, E. J.: Ultraviolet Light Factor in Chlorpromazine Dermatitis , A.M.A. Arch. Dermat 75:38-40, 1957.Crossref 13. Epstein, J. H.; Brunsting, L. A.; Peterson, M. C., and Schwartz, B. E.: A Study of Photosensitivity Occurring with Chlorpromazine Therapy , J. Invest. Dermat. 28:329-338, 1957. 14. Meare, cited by Calnan.4 15. Burckhardt, W.: Largactileczeme mit photoallergischer Komponente , Dermatologica 113:307, 1956.Crossref 16. Schwarz, K. and Speck, M.: Experimentelle Untersuchungen zur Frage der Photoallergie der Sulfonamide , Dermatologica 114:232-243, 1957.Crossref 17. Rives, cited by Calnan.4 18. Pellerat, cited by Calnan.4 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Allergic Photocontact Dermatitis from Promethazine (Phenergan)

A.M.A. Archives of Dermatology , Volume 81 (2) – Feb 1, 1960

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Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1960.03730020011002
Publisher site
See Article on Publisher Site

Abstract

Abstract Allergic photocontact dermatitis from promethazine (Phenergan) seems to be rare in this country. The following case is presented mainly because the allergic nature of the dermatitis appears well documented. Report of a Case A male white bartender, 33 years of age, was seen on Aug. 21, 1958. He suffered from a dermatitis of the hands for about six weeks, apparently due to contacts in his occupation and infection. He had been treated with various ointments, among them promethazine cream. Two days prior to his first visit he again had applied promethazine cream and accidentally had exposed his hands to sunlight. A hyperacute dermatitis followed with swelling and large blisters on the dorsa of both hands, spreading beyond the area involved by the underlying chronic eczema.The acute photocontact dermatitis subsided quickly, but the original "bartender's eczema" persisted with aggravations when he exposed himself to the cleaning and antiseptic solutions of References 1. Controls with these patch and photopatch tests on normal persons were always negative. Long ultraviolet was applied by five minutes of irradiation with filtered (Corning filter No. 597) light from a Kromayer lamp. This light never produces a reaction on normal persons even with four times the time used in the tests. 2. Dr. Hermann Pinkus, Monroe, Mich., did the interpretation and photomicrographs of the biopsy specimens. 3. Burckhardt, W.: Untersuchungen über die Photoaktivität einiger Sulfanilamide , Dermatologica 83:63, 1941.Crossref 4. Burckhardt, W.: Photoallergische Ekzeme durch Sulfanilamidsalben , Dermatologica 96:280-285, 1948.Crossref 5. Epstein, S.: Photoallergy and Primary Phototoxicity to Sulfanilamide , J. Invest. Dermat. 2:43-51, 1939.Crossref 6. Calnan, C. D.: Drug Photosensitivity with Chlorpromazine , Tr. St. John's Hosp. Dermat. Soc. , to be published. 7. Sidi, E.: Les Photosensibilisations spontanées et provoquées , Vie méd. 39:875-884, 1958. 8. Sidi, E.; Hincky, M., and Gervais, A.: Allergic Sensitization and Photosensitization to Phenergan Cream , J. Invest. Dermat. 24:345-352, 1955.Crossref 9. Ippen, H.: Zur Spezifität der Photoallergie, 1958, to be published. 10. Schulz, K. H.; Wiskemann, A., and Wulf, K.: Klinische und experimentelle Untersuchungen über die photodynamische Wirksamkeit von Phenothiazinderivaten, insbesondere von Megaphen , Arch. klin. u. exper. Dermat. 202:285-298, 1956.Crossref 11. Epstein, S., and Rowe, R.: Photoallergy and Photocross-Sensitivity to Phenergan , J. Invest. Dermat. 29:319-326, 1957.Crossref 12. Cahn, M. M., and Levy, E. J.: Ultraviolet Light Factor in Chlorpromazine Dermatitis , A.M.A. Arch. Dermat 75:38-40, 1957.Crossref 13. Epstein, J. H.; Brunsting, L. A.; Peterson, M. C., and Schwartz, B. E.: A Study of Photosensitivity Occurring with Chlorpromazine Therapy , J. Invest. Dermat. 28:329-338, 1957. 14. Meare, cited by Calnan.4 15. Burckhardt, W.: Largactileczeme mit photoallergischer Komponente , Dermatologica 113:307, 1956.Crossref 16. Schwarz, K. and Speck, M.: Experimentelle Untersuchungen zur Frage der Photoallergie der Sulfonamide , Dermatologica 114:232-243, 1957.Crossref 17. Rives, cited by Calnan.4 18. Pellerat, cited by Calnan.4

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Feb 1, 1960

References