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Allergic Contact Hypersensitivity to Nickel, Neomycin, Ethylenediamine, and Benzocaine: Relationships Between Age, Sex, History of Exposure, and Reactivity to Standard Patch Tests and Use Tests in a General Population

Allergic Contact Hypersensitivity to Nickel, Neomycin, Ethylenediamine, and Benzocaine:... Abstract A study population of 1,158 paid adult volunteers was obtained. Prior to patch testing, a history of previous exposure to four allergens also was obtained. Prevalence of positive reactions to patch tests was nickel, 5.8%; neomycin, 1.1%; ethylenediamine, 0.43%; and benzocaine, 0.17%. Nine percent of women reacted to nickel compared with 0.9% of men. There was a strong correlation of nickel sensitivity with a history of pierced ears, earlobe rash, and jewelry rash. Ten of 12 neomycin-positive subjects used neomycin for one week or longer on an inflammatory dermatosis, compared with six of 36 age-, race-, and sex-matched controls. By history, 85% were exposed to benzocaine, 48% to neomycin, and 15% to Mycolog (ethylenediamine). Of 127 patients referred to clinics for evaluation of contact dermatitis, 11% yielded positive tests to nickel, 6.3% to neomycin, 3.1% to ethylenediamine, and 1.6% to benzocaine. Data obtained from testing contact dermatitis patients are not applicable to the general population. (Arch Dermatol 115:959-962, 1979) References 1. Rudner EJ, Clendenning WE, Epstein E, et al: Epidemiology of contact dermatitis in North America: 1972 . Arch Dermatol 108:537-540, 1973.Crossref 2. Fregert S, Hjorth N, Magnusson B, et al: Epidemiology of contact dermatitis . Trans St Johns Hosp Dermatol Soc 55:17-35, 1969. 3. Bandmann HJ, Calnan DC, Cronin E, et al: Dermatitis from applied medicaments . Arch Dermatol 106:335-337, 1972.Crossref 4. Allan AM, Taplin D: Use and misuse of "epidemiology." Arch Dermatol 110:131-132, 1974. 5. Documenta Geigy: Scientific Tables , ed 6. New York, Geigy Pharmaceuticals, 1962. 6. Fleiss JL: Statistical Methods for Rates and Proportions . New York, John Wiley & Sons, 1973, pp 80-83. 7. Fisher AA: Contact Dermatitis , ed 2. Philadelphia, Lea & Febiger, 1973. 8. Fisher AA, Shapiro A: Allergic eczematous contact dermatitis due to metallic nickel . JAMA 161:717-721, 1956.Crossref 9. Calnan CD: Nickel sensitivity in women . Int Arch Allergy 11:73-80, 1957.Crossref 10. Gaul LE: Development of allergic nickel dermatitis from earrings . JAMA 200:186-188, 1967.Crossref 11. Kirton V, Munro-Ashman D: Contact dermatitis from neomycin and framycetin . Lancet 1:138-139, 1965.Crossref 12. Calnan CD, Sarkany I: Contact dermatitis from neomycin . Br J Dermatol 70:435-445, 1958.Crossref 13. Hjorth N, Thomsen K: Differences in the sensitivity capacity of neomycin in creams and in ointments . Br J Dermatol 80:163-169, 1968.Crossref 14. Provost TT, Jillson OF: Ethylenediamine contact dermatitis . Arch Dermatol 96:231-234, 1967.Crossref 15. Epstein E, Maibach HI: Ethylenediamine allergic contact dermatitis . Arch Dermatol 98:476-477, 1968.Crossref 16. Schorr WF, Wenzel FJ, Hegedus SI: Cross-sensitivity and aminoglycoside antibiotics . Arch Dermatol 107:533-539, 1973.Crossref 17. Patrick J, Panzer JD, Derbes VJ: Neomycin sensitivity in the normal (nonatopic) individual . Arch Dermatol 102:532-535, 1970.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Allergic Contact Hypersensitivity to Nickel, Neomycin, Ethylenediamine, and Benzocaine: Relationships Between Age, Sex, History of Exposure, and Reactivity to Standard Patch Tests and Use Tests in a General Population

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Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1979.04010080023015
Publisher site
See Article on Publisher Site

Abstract

Abstract A study population of 1,158 paid adult volunteers was obtained. Prior to patch testing, a history of previous exposure to four allergens also was obtained. Prevalence of positive reactions to patch tests was nickel, 5.8%; neomycin, 1.1%; ethylenediamine, 0.43%; and benzocaine, 0.17%. Nine percent of women reacted to nickel compared with 0.9% of men. There was a strong correlation of nickel sensitivity with a history of pierced ears, earlobe rash, and jewelry rash. Ten of 12 neomycin-positive subjects used neomycin for one week or longer on an inflammatory dermatosis, compared with six of 36 age-, race-, and sex-matched controls. By history, 85% were exposed to benzocaine, 48% to neomycin, and 15% to Mycolog (ethylenediamine). Of 127 patients referred to clinics for evaluation of contact dermatitis, 11% yielded positive tests to nickel, 6.3% to neomycin, 3.1% to ethylenediamine, and 1.6% to benzocaine. Data obtained from testing contact dermatitis patients are not applicable to the general population. (Arch Dermatol 115:959-962, 1979) References 1. Rudner EJ, Clendenning WE, Epstein E, et al: Epidemiology of contact dermatitis in North America: 1972 . Arch Dermatol 108:537-540, 1973.Crossref 2. Fregert S, Hjorth N, Magnusson B, et al: Epidemiology of contact dermatitis . Trans St Johns Hosp Dermatol Soc 55:17-35, 1969. 3. Bandmann HJ, Calnan DC, Cronin E, et al: Dermatitis from applied medicaments . Arch Dermatol 106:335-337, 1972.Crossref 4. Allan AM, Taplin D: Use and misuse of "epidemiology." Arch Dermatol 110:131-132, 1974. 5. Documenta Geigy: Scientific Tables , ed 6. New York, Geigy Pharmaceuticals, 1962. 6. Fleiss JL: Statistical Methods for Rates and Proportions . New York, John Wiley & Sons, 1973, pp 80-83. 7. Fisher AA: Contact Dermatitis , ed 2. Philadelphia, Lea & Febiger, 1973. 8. Fisher AA, Shapiro A: Allergic eczematous contact dermatitis due to metallic nickel . JAMA 161:717-721, 1956.Crossref 9. Calnan CD: Nickel sensitivity in women . Int Arch Allergy 11:73-80, 1957.Crossref 10. Gaul LE: Development of allergic nickel dermatitis from earrings . JAMA 200:186-188, 1967.Crossref 11. Kirton V, Munro-Ashman D: Contact dermatitis from neomycin and framycetin . Lancet 1:138-139, 1965.Crossref 12. Calnan CD, Sarkany I: Contact dermatitis from neomycin . Br J Dermatol 70:435-445, 1958.Crossref 13. Hjorth N, Thomsen K: Differences in the sensitivity capacity of neomycin in creams and in ointments . Br J Dermatol 80:163-169, 1968.Crossref 14. Provost TT, Jillson OF: Ethylenediamine contact dermatitis . Arch Dermatol 96:231-234, 1967.Crossref 15. Epstein E, Maibach HI: Ethylenediamine allergic contact dermatitis . Arch Dermatol 98:476-477, 1968.Crossref 16. Schorr WF, Wenzel FJ, Hegedus SI: Cross-sensitivity and aminoglycoside antibiotics . Arch Dermatol 107:533-539, 1973.Crossref 17. Patrick J, Panzer JD, Derbes VJ: Neomycin sensitivity in the normal (nonatopic) individual . Arch Dermatol 102:532-535, 1970.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Aug 1, 1979

References