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Allergic and Anaphylactoid Inflammation

Allergic and Anaphylactoid Inflammation To the Editor:— The first reports on allergic phenomena uniformly stressed that sensitization produces a state without protection (anaphylaxis) against minimal amounts of the antigen. Testing procedures for the detection of allergies are only reliable when carried out with minimal amounts of the allergen. This rule is of utmost importance when testing with anaphylactoid substances. Intracutaneous or epicutaneous applications of such substances in higher amounts might easily produce anaphylactoid inflammation which is indistinguishable from true allergic inflammation. In "Allergy to Dermatologic Agents" (198:517, 1966), it was claimed that patch tests for neomycin allergy should be performed with 20% to 40% solutions. Even though the exact amount of solution for the testing procedure is not mentioned, one might assume that an amount of 50 to 200 mg of neomycin is applied on skin areas with greatly enhanced penetration. Studying the table in the paper, one finds the number of "allergic" http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Allergic and Anaphylactoid Inflammation

JAMA , Volume 201 (2) – Jul 10, 1967

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Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1967.03130020089035
Publisher site
See Article on Publisher Site

Abstract

To the Editor:— The first reports on allergic phenomena uniformly stressed that sensitization produces a state without protection (anaphylaxis) against minimal amounts of the antigen. Testing procedures for the detection of allergies are only reliable when carried out with minimal amounts of the allergen. This rule is of utmost importance when testing with anaphylactoid substances. Intracutaneous or epicutaneous applications of such substances in higher amounts might easily produce anaphylactoid inflammation which is indistinguishable from true allergic inflammation. In "Allergy to Dermatologic Agents" (198:517, 1966), it was claimed that patch tests for neomycin allergy should be performed with 20% to 40% solutions. Even though the exact amount of solution for the testing procedure is not mentioned, one might assume that an amount of 50 to 200 mg of neomycin is applied on skin areas with greatly enhanced penetration. Studying the table in the paper, one finds the number of "allergic"

Journal

JAMAAmerican Medical Association

Published: Jul 10, 1967

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