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All ACE Inhibitors Are Not Alike-Reply

All ACE Inhibitors Are Not Alike-Reply Abstract In Reply.— The comments by Cheng are quite valid and further emphasize the differences between various angiotensin-converting enzyme inhibitors. Although the presence of the sulfhydryl group in captopril has been shown to contribute to captopril's capacity to act as a free radical scavenger,12 the clinical significance of this phenomenon is not established. In the study by McMurray et al,2 the investigators evaluated 29 patients with chronic congestive heart failure by measurement of plasma malondialdehyde (an indirect indicator of free radical-mediated damage to lipids) and demonstrated that, compared with (Continued from p 1670.) healthy control subjects, the patients with congestive heart failure had higher plasma malondialdehyde and lower thiol concentrations (P<.05). Although it is true that increased free radical activity in patients with congestive heart failure may have important implications since free radicals cause impairment of myocyte metabolism and contraction,3 there is as yet little available information References 1. Westlin W, Mullane K. Does captopril attenuate reperfusion-induced myocardial dysfunction by scavenging free radicals? Circulation . 1988;77( (suppl 1) ):30-39. 2. McMurray J, McLay J, Chopra M, Bridges A, Belch JJF. Evidence for enhanced free radical activity in chronic congestive heart failure secondary to coronary artery disease . Am J Cardiol . 1990;65:1261-1262.Crossref 3. Goldhaber JI, Ji S, Lamp ST, Weiss JN. Effects of exogenous free radical on electromechanical function and metabolism in isolated rabbit and guinea pig ventricle: implications for ischaemia and reperfusioninjury . J Clin Invest . 1989;83:1800-1809.Crossref 4. Powell JS, Clozel JP, Müller RKM, et al. Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury . Science . 1989;245:186-188.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

All ACE Inhibitors Are Not Alike-Reply

Archives of Internal Medicine , Volume 151 (8) – Aug 1, 1991

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Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1991.00400080150036
Publisher site
See Article on Publisher Site

Abstract

Abstract In Reply.— The comments by Cheng are quite valid and further emphasize the differences between various angiotensin-converting enzyme inhibitors. Although the presence of the sulfhydryl group in captopril has been shown to contribute to captopril's capacity to act as a free radical scavenger,12 the clinical significance of this phenomenon is not established. In the study by McMurray et al,2 the investigators evaluated 29 patients with chronic congestive heart failure by measurement of plasma malondialdehyde (an indirect indicator of free radical-mediated damage to lipids) and demonstrated that, compared with (Continued from p 1670.) healthy control subjects, the patients with congestive heart failure had higher plasma malondialdehyde and lower thiol concentrations (P<.05). Although it is true that increased free radical activity in patients with congestive heart failure may have important implications since free radicals cause impairment of myocyte metabolism and contraction,3 there is as yet little available information References 1. Westlin W, Mullane K. Does captopril attenuate reperfusion-induced myocardial dysfunction by scavenging free radicals? Circulation . 1988;77( (suppl 1) ):30-39. 2. McMurray J, McLay J, Chopra M, Bridges A, Belch JJF. Evidence for enhanced free radical activity in chronic congestive heart failure secondary to coronary artery disease . Am J Cardiol . 1990;65:1261-1262.Crossref 3. Goldhaber JI, Ji S, Lamp ST, Weiss JN. Effects of exogenous free radical on electromechanical function and metabolism in isolated rabbit and guinea pig ventricle: implications for ischaemia and reperfusioninjury . J Clin Invest . 1989;83:1800-1809.Crossref 4. Powell JS, Clozel JP, Müller RKM, et al. Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury . Science . 1989;245:186-188.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Aug 1, 1991

References