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ALBUMIN AND GLOBULIN CHANGES IN BURNS AS DEMONSTRATED BY ELECTROPHORESIS

ALBUMIN AND GLOBULIN CHANGES IN BURNS AS DEMONSTRATED BY ELECTROPHORESIS Abstract HERETOFORE there has been no report of a systematic electrophoretic study of a series of human burn patients. Shedlovsky and Scudder1 described an increase in the alpha globulin fraction of a single patient suffering from first, second and third degree burns. Murakami2 studied the chemolytic albumin-globulin ratios of four patients who had suffered first and second degree burns and found that the globulin portion was somewhat increased at the expense of the albumin portion. In the present investigation, blood protein patterns for a series of burn patients have been studied at regular intervals from the onset of thermal injury, through the period of the body's response to this stress, and until the onset of healing. Altogether, blood serum and blood plasma of eight hospitalized patients suffering primarily second and third degree burns ranging in extent from 10 to 35% of the total surface area of the body have References 1. Shedlovsky, T., and Scudder, J.: A Comparison of Erythrocyte Sedimentation Rates and Electrophoretic Patterns of Normal and Pathological Human Blood , J. Exper. Med. 75:119-126, 1942.Crossref 2. Murakami, T.: Studies on the Serum Proteins in Burns , Jap. J. Dermat. & Urol. 34:85, 1933. 3. Reiner, M.; Fenichel, R. L., and Stern, K. G.: Electrophoretic Studies on the Protein Distribution in Normal Human Serum , Acta haemat. 3:202-210, 1950. 4. Named concentrations were identified on the basis of electrophoretic mobility. 5. Woodruff, L. M., and Gibson, S. T.: Use of Human Albumin in Military Medicine: The Clinical Evaluation of Human Albumin , U. S. Nav. M. Bull. 40:791-796, 1942. 6. White, A., and Dougherty, T.: The Role of Lymphocytes in Normal and Immune Globulin Production and the Mode of Release of Globulin from Lymphocytes , Ann. New York Acad. Sc. 46:859-882, 1946. 7. Harris, T. N.; Grimm, E.: Mertens, E., and Ehrich, W. S.: The Role of the Lymphocyte in Antibody Formation , J. Exper. Med. 81:73-83, 1945. 8. Kass, E. H.: The Occurrence of Normal Serum Gamma-Globulin in Human Lymphocytes , Science 101:337-338, 1945. 9. Perlmann, G. E.; Glenn, W. W. L., and Kaufman, D.: Changes in the Electrophoretic Pattern in Lymph and Serum in Experimental Burns , J. Clin. Invest. 22:627-632, 1943. 10. Roberts, S., and White, A.: Studies on the Origin of the Serum Proteins , J. Biol. Chem. 180:505-516, 1949. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives Surgery American Medical Association

ALBUMIN AND GLOBULIN CHANGES IN BURNS AS DEMONSTRATED BY ELECTROPHORESIS

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Publisher
American Medical Association
Copyright
Copyright © 1952 American Medical Association. All Rights Reserved.
ISSN
0096-6908
DOI
10.1001/archsurg.1952.01260010753001
Publisher site
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Abstract

Abstract HERETOFORE there has been no report of a systematic electrophoretic study of a series of human burn patients. Shedlovsky and Scudder1 described an increase in the alpha globulin fraction of a single patient suffering from first, second and third degree burns. Murakami2 studied the chemolytic albumin-globulin ratios of four patients who had suffered first and second degree burns and found that the globulin portion was somewhat increased at the expense of the albumin portion. In the present investigation, blood protein patterns for a series of burn patients have been studied at regular intervals from the onset of thermal injury, through the period of the body's response to this stress, and until the onset of healing. Altogether, blood serum and blood plasma of eight hospitalized patients suffering primarily second and third degree burns ranging in extent from 10 to 35% of the total surface area of the body have References 1. Shedlovsky, T., and Scudder, J.: A Comparison of Erythrocyte Sedimentation Rates and Electrophoretic Patterns of Normal and Pathological Human Blood , J. Exper. Med. 75:119-126, 1942.Crossref 2. Murakami, T.: Studies on the Serum Proteins in Burns , Jap. J. Dermat. & Urol. 34:85, 1933. 3. Reiner, M.; Fenichel, R. L., and Stern, K. G.: Electrophoretic Studies on the Protein Distribution in Normal Human Serum , Acta haemat. 3:202-210, 1950. 4. Named concentrations were identified on the basis of electrophoretic mobility. 5. Woodruff, L. M., and Gibson, S. T.: Use of Human Albumin in Military Medicine: The Clinical Evaluation of Human Albumin , U. S. Nav. M. Bull. 40:791-796, 1942. 6. White, A., and Dougherty, T.: The Role of Lymphocytes in Normal and Immune Globulin Production and the Mode of Release of Globulin from Lymphocytes , Ann. New York Acad. Sc. 46:859-882, 1946. 7. Harris, T. N.; Grimm, E.: Mertens, E., and Ehrich, W. S.: The Role of the Lymphocyte in Antibody Formation , J. Exper. Med. 81:73-83, 1945. 8. Kass, E. H.: The Occurrence of Normal Serum Gamma-Globulin in Human Lymphocytes , Science 101:337-338, 1945. 9. Perlmann, G. E.; Glenn, W. W. L., and Kaufman, D.: Changes in the Electrophoretic Pattern in Lymph and Serum in Experimental Burns , J. Clin. Invest. 22:627-632, 1943. 10. Roberts, S., and White, A.: Studies on the Origin of the Serum Proteins , J. Biol. Chem. 180:505-516, 1949.

Journal

A.M.A. Archives SurgeryAmerican Medical Association

Published: Jun 1, 1952

References

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