Abstract • In 25 cat eyes 0.7 mL of air and in 11 cat eyes 0.7 mL of balanced salt solution were injected into the anterior chamber after paracentesis. This air persisted for three to four days, and specular microscopy was performed before and two months after air injection. There was an overall significant decrease in the endothelial cell density as a percentage of the preinjection density for the eyes with air when compared with those with balanced salt solution (102% ± 7% for balanced salt solution and 93% ± 11% for air). Thus, while air is generally well tolerated by the corneal endothelium, it is a toxic material in the anterior chamber and probably can cause endothelial damage. If not otherwise indicated and if safe to do so, it seems best to avoid its use or to replace it with physiologic solutions after its use. References 1. Van Horn DL, Edelhauser HF, Arberg TM, et al: In vivo effects of air and sulfur hexafluoride gas on rabbit corneal endothelium . Invest Ophthalmol 11:1028-1036, 1972. 2. Leibowitz HM, Laing RA: Corneal endothelium: The effect of air in the anterior chamber . Arch Ophthalmol 92:227-230, 1974.Crossref 3. Stocker FW: The Endothelium of the Cornea and Its Clinical Implications . Springfield, Ill, Charles C Thomas Publisher, 1971, p 67. 4. Van Horn DL, Sendele DD, Seideman S, et al: Regenerative capacity of the corneal endothelium in rabbit and cat . Invest Ophthalmol 16:597-613, 1977.
Archives of Ophthalmology – American Medical Association
Published: Jul 1, 1980
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