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Age-Related Differences in Cochlear Microcirculation and Auditory Brain Stem Response

Age-Related Differences in Cochlear Microcirculation and Auditory Brain Stem Response Abstract Objective: To examine possible age-related differences in auditory sensitivity and cochlear vascular properties. Design: This study is designed to provide information regarding cochlear function using physiological and audiological measures. Each animal underwent intravital microscopic evaluation of red blood cell velocity, vessel diameter, and vascular permeability in the second turn of the cochlear lateral wall. Auditory brain stem responses were used to determine hearing sensitivity. Subjects: Four age ranges of male Fischer rats were studied: young, 2 to 4 months (n=9); mid-young, 9 to 11 months (n=8); mid-old, 18 to 20 months (n=6); and old, 30 to 34 months (n=10). Results: Auditory brain stem response testing showed an age-related decrease in auditory sensitivity. Intravital microscopic analysis showed age-related statistically significant decreases in red blood cell velocity and increased vascular permeability with a trend for reduced capillary diameters. Conclusions: The process of aging is associated with many biochemical and physiological changes that include decrease in cellular water concentration, ionic changes, and decreased elasticity of cellular membranes. One contributing factor to this process may be altered vascular characteristics, such as reduced flow and vascular plasticity, as well as increased vascular permeability. These age-related changes may result in reductions in oxygen and nutrient delivery, and also waste elimination. Our results suggest that progressive age-associated vascular compromise may be a contributing factor in presbycusis.Arch Otolaryngol Head Neck Surg. 1996;122:1221-1226 References 1. Gates GA, Caspery DM, Clark W, Pillsbury HC. Presbycusis . Otolaryngol Head Neck Surg . 1986;100:266-271. 2. Arlinger S. Audiometric profile in presbycusis . Acta OtolaryngolSuppl (Stockh) . 1990;476:85-89. 3. Davis AC, Ostri B, Parving A. Longitudinal study of hearing . Acta Otolaryngol Suppl (Stockh) . 1990;476:12-22. 4. Gacek RR, Schuknecht HF. Pathology of presbycusis . Int Natl Audiol . 1969;8: 199-209.Crossref 5. Harkins SW. Effects of age and interstimulus interval on the brain stem auditory evoked potential . Int J Neurosci . 1981;15:107-118.Crossref 6. Rosenhall U, Pederson K, Dotevall M. Effects of presbycusis and other types of hearing loss on auditory brain stem responses . Scand Audiol . 1986;15:179-185. 7. Hoefding V, Feldman ML. Changes with advanced age in the morphology of the rat auditory nerve . Soc Neurosci . 1987;13:1259. Abstract. 8. Semsei I, Szeszek F, Nagy I. In-vivo studies of the age dependent decrease of the rates of total and mRNA synthesis in the brain cortex of rats . Arch Gerontol Geriatr . 1982;1:29-42.Crossref 9. Richardson A, Butler JA, Rutherford MS, et al. Effects of age and dietary restrictions on the expression of alpha-2 u-microglobulin . J Biol Chem . 1987; 262:605-613. 10. Johnson LG, Hawkins JE Jr. Vascular changes in the human inner ear associated with aging . Ann Otol Rhinol Laryngol . 1972;81:361-376. 11. Prazma J, Butler B, Waters G, Anderson TL, Pilsbury HC. Proceedings of the 71st annual meeting . Fed Am Soc Ex Biol . 1984;46:1538. 12. Gatehouse S, Lowe GD. Whole blood viscosity and red cell filter ability as factors in sensorineural hearing impairment in the elderly . Acta Otolaryngol (Stockh) . 1990;476:37-43. 13. Gratton MA, Schulte BA. Alterations in microvasculature are associated with atrophy of the stria vascularis in quiet-aged gerbils . Hear Res . 1995;82:44-52.Crossref 14. Axelsson A. The cochlear blood vessels in guinea pigs of different ages . Acta Otolaryngol (Stockh) . 1971;72:172-181.Crossref 15. Boettcher FA, Mills JH, Norton BL. Age-related changes in auditory evoked potentials of gerbils, I: response amplitudes . Hear Res . 1993;71:137-145.Crossref 16. Boettcher FA, Mills JH, Norton BL, Schmiedt RA. Age-related changes in auditory evoked potentials of gerbils, II: response latencies . Hear Res . 1993;71: 146-156.Crossref 17. Wayland H, Fraser WG. Modern Techniques in Physiological Sciences . Orlando, Fla: Academic Press Inc; 1975:125-135. 18. Nuttall AL. Velocity of red blood cell flow in capillaries of guinea pig cochlea . Hear Res . 1987;27:121-128.Crossref 19. Huber M, Franzceck UK, Bollinger A. Permeability of superficial lymphatic capillaries in human skin to FITC-labeled dextrans 40,000 and 150,000 . Int J Microsc Clin Exp . 1984;3:59-69. 20. Quirk WS, Avinash G, Nuttall AL, Miller JM. The influence of loud sound on red blood cell velocity and blood vessel diameter in the cochlea . Hear Res . 1991;63:102-107.Crossref 21. Avinash GB, Quirk WS, Nuttall AL. Three dimensional analysis of contrast filled micro vessel diameters . Microvasc Res . 1993;45:180-192.Crossref 22. Crowley DE, Schramm VL, Swain RE, Swanson SN. Analysis of age related changes in electric responses from the inner ear of rats . Ann Otol Rhino Laryngol . 1972;81:739-746. 23. Crowley DE, Schramm VL, Swain RE, Swanson SN. Age related waveform changes of 8th nerve potentials in rats . Laryngoscope . 1973;83:264-275.Crossref 24. Konishi T, Butler R, Fernandez C. Effect of anoxia on cochlear potentials . J Acoust Soc Am . 1961;33:349-356.Crossref 25. Nuttall AL. Dynamic aspects of guinea pig inner hair cell receptor potentials with transient asphyxia . Hear Res . 1984;16:1-16.Crossref 26. Seidman MD, Quirk WS, Nuttall AL, Schweitzer VG. The protective effect of allopurinol and SOD-PEG on ischemic induced cochlear damage . Otolaryngol Head Neck Surg . 1991;105:457-463. 27. Seidman MD, Quirk WS. The protective effect of U74006F on ischemic induced cochlear damage . Otolaryngol Head Neck Surg . 1991;105:511-516. 28. Roosa DB. Presbycusis . Trans Am Otol Soc . 1885;3:449-460. 29. Henry KR, McGinn MD, Chole RA. Age-related auditory loss in the Mongolian gerbil . Arch Otolaryngol . 1980;228:233-238. 30. Willot JF, Parham K, Hunter KP. Comparison of the auditory sensitivity of neurons in the cochlear nucleus and inferior colliculus of young and aging C57BL/6J and CBA/J mice . Hear Res . 1991;52:78-94.Crossref 31. Simpson GV, Knight RT, Brailowsky S, Prospero-Garcia O, Scabini D. Altered peripheral and brain stem auditory function in aged rats . Brain Res . 1985;348:28-35.Crossref 32. Soucek S, Michaels L, Frohlich A. Pathological changes in the organ of corti in presbycusis as revealed by micro slicing and staining . Acta Otolaryngol Suppl (Stockh) . 1987;436:93-102.Crossref 33. Nadol JB Jr. Application to electron microscopy to human otopathology: ultrastructural findings in neural presbycusis, Meniere's disease and Usher's syndrome . Acta Otolaryngol (Stockh) . 1988;105:411-419.Crossref 34. Keithley EM, Feldman ML. Hair-cell counts in age graded series of rat cochleas . Hear Res . 1982;93:249-262.Crossref 35. Hallberg OE. Sudden deafness and its relation to atherosclerosis . JAMA . 1957; 165:1649-1716.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology - Head & Neck Surgery American Medical Association

Age-Related Differences in Cochlear Microcirculation and Auditory Brain Stem Response

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Publisher
American Medical Association
Copyright
Copyright © 1996 American Medical Association. All Rights Reserved.
ISSN
0886-4470
eISSN
1538-361X
DOI
10.1001/archotol.1996.01890230067013
Publisher site
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Abstract

Abstract Objective: To examine possible age-related differences in auditory sensitivity and cochlear vascular properties. Design: This study is designed to provide information regarding cochlear function using physiological and audiological measures. Each animal underwent intravital microscopic evaluation of red blood cell velocity, vessel diameter, and vascular permeability in the second turn of the cochlear lateral wall. Auditory brain stem responses were used to determine hearing sensitivity. Subjects: Four age ranges of male Fischer rats were studied: young, 2 to 4 months (n=9); mid-young, 9 to 11 months (n=8); mid-old, 18 to 20 months (n=6); and old, 30 to 34 months (n=10). Results: Auditory brain stem response testing showed an age-related decrease in auditory sensitivity. Intravital microscopic analysis showed age-related statistically significant decreases in red blood cell velocity and increased vascular permeability with a trend for reduced capillary diameters. Conclusions: The process of aging is associated with many biochemical and physiological changes that include decrease in cellular water concentration, ionic changes, and decreased elasticity of cellular membranes. One contributing factor to this process may be altered vascular characteristics, such as reduced flow and vascular plasticity, as well as increased vascular permeability. These age-related changes may result in reductions in oxygen and nutrient delivery, and also waste elimination. Our results suggest that progressive age-associated vascular compromise may be a contributing factor in presbycusis.Arch Otolaryngol Head Neck Surg. 1996;122:1221-1226 References 1. Gates GA, Caspery DM, Clark W, Pillsbury HC. Presbycusis . Otolaryngol Head Neck Surg . 1986;100:266-271. 2. Arlinger S. Audiometric profile in presbycusis . Acta OtolaryngolSuppl (Stockh) . 1990;476:85-89. 3. Davis AC, Ostri B, Parving A. Longitudinal study of hearing . Acta Otolaryngol Suppl (Stockh) . 1990;476:12-22. 4. Gacek RR, Schuknecht HF. Pathology of presbycusis . Int Natl Audiol . 1969;8: 199-209.Crossref 5. Harkins SW. Effects of age and interstimulus interval on the brain stem auditory evoked potential . Int J Neurosci . 1981;15:107-118.Crossref 6. Rosenhall U, Pederson K, Dotevall M. Effects of presbycusis and other types of hearing loss on auditory brain stem responses . Scand Audiol . 1986;15:179-185. 7. Hoefding V, Feldman ML. Changes with advanced age in the morphology of the rat auditory nerve . Soc Neurosci . 1987;13:1259. Abstract. 8. Semsei I, Szeszek F, Nagy I. In-vivo studies of the age dependent decrease of the rates of total and mRNA synthesis in the brain cortex of rats . Arch Gerontol Geriatr . 1982;1:29-42.Crossref 9. Richardson A, Butler JA, Rutherford MS, et al. Effects of age and dietary restrictions on the expression of alpha-2 u-microglobulin . J Biol Chem . 1987; 262:605-613. 10. Johnson LG, Hawkins JE Jr. Vascular changes in the human inner ear associated with aging . Ann Otol Rhinol Laryngol . 1972;81:361-376. 11. Prazma J, Butler B, Waters G, Anderson TL, Pilsbury HC. Proceedings of the 71st annual meeting . Fed Am Soc Ex Biol . 1984;46:1538. 12. Gatehouse S, Lowe GD. Whole blood viscosity and red cell filter ability as factors in sensorineural hearing impairment in the elderly . Acta Otolaryngol (Stockh) . 1990;476:37-43. 13. Gratton MA, Schulte BA. Alterations in microvasculature are associated with atrophy of the stria vascularis in quiet-aged gerbils . Hear Res . 1995;82:44-52.Crossref 14. Axelsson A. The cochlear blood vessels in guinea pigs of different ages . Acta Otolaryngol (Stockh) . 1971;72:172-181.Crossref 15. Boettcher FA, Mills JH, Norton BL. Age-related changes in auditory evoked potentials of gerbils, I: response amplitudes . Hear Res . 1993;71:137-145.Crossref 16. Boettcher FA, Mills JH, Norton BL, Schmiedt RA. Age-related changes in auditory evoked potentials of gerbils, II: response latencies . Hear Res . 1993;71: 146-156.Crossref 17. Wayland H, Fraser WG. Modern Techniques in Physiological Sciences . Orlando, Fla: Academic Press Inc; 1975:125-135. 18. Nuttall AL. Velocity of red blood cell flow in capillaries of guinea pig cochlea . Hear Res . 1987;27:121-128.Crossref 19. Huber M, Franzceck UK, Bollinger A. Permeability of superficial lymphatic capillaries in human skin to FITC-labeled dextrans 40,000 and 150,000 . Int J Microsc Clin Exp . 1984;3:59-69. 20. Quirk WS, Avinash G, Nuttall AL, Miller JM. The influence of loud sound on red blood cell velocity and blood vessel diameter in the cochlea . Hear Res . 1991;63:102-107.Crossref 21. Avinash GB, Quirk WS, Nuttall AL. Three dimensional analysis of contrast filled micro vessel diameters . Microvasc Res . 1993;45:180-192.Crossref 22. Crowley DE, Schramm VL, Swain RE, Swanson SN. Analysis of age related changes in electric responses from the inner ear of rats . Ann Otol Rhino Laryngol . 1972;81:739-746. 23. Crowley DE, Schramm VL, Swain RE, Swanson SN. Age related waveform changes of 8th nerve potentials in rats . Laryngoscope . 1973;83:264-275.Crossref 24. Konishi T, Butler R, Fernandez C. Effect of anoxia on cochlear potentials . J Acoust Soc Am . 1961;33:349-356.Crossref 25. Nuttall AL. Dynamic aspects of guinea pig inner hair cell receptor potentials with transient asphyxia . Hear Res . 1984;16:1-16.Crossref 26. Seidman MD, Quirk WS, Nuttall AL, Schweitzer VG. The protective effect of allopurinol and SOD-PEG on ischemic induced cochlear damage . Otolaryngol Head Neck Surg . 1991;105:457-463. 27. Seidman MD, Quirk WS. The protective effect of U74006F on ischemic induced cochlear damage . Otolaryngol Head Neck Surg . 1991;105:511-516. 28. Roosa DB. Presbycusis . Trans Am Otol Soc . 1885;3:449-460. 29. Henry KR, McGinn MD, Chole RA. Age-related auditory loss in the Mongolian gerbil . Arch Otolaryngol . 1980;228:233-238. 30. Willot JF, Parham K, Hunter KP. Comparison of the auditory sensitivity of neurons in the cochlear nucleus and inferior colliculus of young and aging C57BL/6J and CBA/J mice . Hear Res . 1991;52:78-94.Crossref 31. Simpson GV, Knight RT, Brailowsky S, Prospero-Garcia O, Scabini D. Altered peripheral and brain stem auditory function in aged rats . Brain Res . 1985;348:28-35.Crossref 32. Soucek S, Michaels L, Frohlich A. Pathological changes in the organ of corti in presbycusis as revealed by micro slicing and staining . Acta Otolaryngol Suppl (Stockh) . 1987;436:93-102.Crossref 33. Nadol JB Jr. Application to electron microscopy to human otopathology: ultrastructural findings in neural presbycusis, Meniere's disease and Usher's syndrome . Acta Otolaryngol (Stockh) . 1988;105:411-419.Crossref 34. Keithley EM, Feldman ML. Hair-cell counts in age graded series of rat cochleas . Hear Res . 1982;93:249-262.Crossref 35. Hallberg OE. Sudden deafness and its relation to atherosclerosis . JAMA . 1957; 165:1649-1716.Crossref

Journal

Archives of Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: Nov 1, 1996

References