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Adult Stem Cell Therapy and Heart Failure, 2000 to 2016

Adult Stem Cell Therapy and Heart Failure, 2000 to 2016 Key PointsQuestionCan adult stem cell therapy effectively treat patients with heart failure? FindingsIn this systematic review, we found that adult stem cells may release cardioprotective paracrine factors that activate endogenous pathways, leading to myocardial repair; however, randomized clinical trials have found only a modest benefit in patients receiving stem cell therapy. The lack of a significant benefit may result from variations in trial methods, discrepancies in reporting, and an overreliance on surrogate end points. MeaningAlthough stem cell therapy for cardiovascular disease is not yet ready for routine clinical application, significant progress continues to be made. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Cardiology American Medical Association

Adult Stem Cell Therapy and Heart Failure, 2000 to 2016

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Publisher
American Medical Association
Copyright
Copyright 2016 American Medical Association. All Rights Reserved.
ISSN
2380-6583
eISSN
2380-6591
DOI
10.1001/jamacardio.2016.2225
pmid
27557438
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionCan adult stem cell therapy effectively treat patients with heart failure? FindingsIn this systematic review, we found that adult stem cells may release cardioprotective paracrine factors that activate endogenous pathways, leading to myocardial repair; however, randomized clinical trials have found only a modest benefit in patients receiving stem cell therapy. The lack of a significant benefit may result from variations in trial methods, discrepancies in reporting, and an overreliance on surrogate end points. MeaningAlthough stem cell therapy for cardiovascular disease is not yet ready for routine clinical application, significant progress continues to be made.

Journal

JAMA CardiologyAmerican Medical Association

Published: Oct 24, 2016

References