Key PointsQuestionCan adult stem cell therapy effectively treat patients with heart failure? FindingsIn this systematic review, we found that adult stem cells may release cardioprotective paracrine factors that activate endogenous pathways, leading to myocardial repair; however, randomized clinical trials have found only a modest benefit in patients receiving stem cell therapy. The lack of a significant benefit may result from variations in trial methods, discrepancies in reporting, and an overreliance on surrogate end points. MeaningAlthough stem cell therapy for cardiovascular disease is not yet ready for routine clinical application, significant progress continues to be made.
JAMA Cardiology – American Medical Association
Published: Oct 24, 2016
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