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Adrenalectomy for Hopeless Carcinoma of the Prostate

Adrenalectomy for Hopeless Carcinoma of the Prostate Abstract There are only a few human malignancies which are influenced in growth and invasive behavior by hormones. Carcinomas of the breast, prostate, thyroid, and ovary are the lesions most commonly influenced, but mammary and prostatic malignancies are sometimes favorably changed when their respective hormones are abolished or nearly abolished by hypophysectomy or adrenalectomy after the respective sex organs have been removed. Growth in certain breast carcinomas is probably enhanced by an increase in estrogen, and in certain prostatic carcinomas, growth seems to accelerate by increased androgen. Observations leading to this knowledge arose after bilateral oophorectomy and bilateral orchiectomy apparently slowed the invasion of the body by these malignancies. It followed that other hormonal glands, capable of producing androgen and estrogen when the sex organs are removed, may by their hormonal activity cause the carcinoma to grow.1 When substitutive hormonal therapy was available, eradication of the adrenal gland was exploited References 1. Huggins, C., and Hodges, C. V.: Studies on Prostatic Cancer; Effect of Castration, of Estrogen, and of Androgen Injection on Serum Phosphatases in Metastatic Carcinoma of Prostate , Cancer Res. 1:293-297 ( (April) ) 1941. 2. Taylor, S. G., III; Li, M. C.; Eckles, N.; Slaughter, D. P., and McDonald, J. H.: Effect of Surgical Addison's Disease on Advanced Carcinoma of the Breast and Prostate , Cancer 6:997-1009 ( (Sept.) ) 1953.Crossref 3. West, D. D.; Hollander, V. P.; Whitmore, W. F.; Randall, H. T., and Pearson, O. H.: The Effect of Bilateral Adrenalectomy upon Neoplastic Disease in Man , Cancer 5:1009-1018 ( (Sept.) ) 1952.Crossref 4. Pyrah, L. N.: Bilateral Adrenalectomy in the Treatment of Mammary and Prostatic Cancer , Proc. Roy. Soc. Med. 47:1002-1006 ( (May 27) ) 1954. 5. Harrison, J. H.; Thorn, G. W., and Jenkins, D.: Total Adrenalectomy for Reactivated Carcinoma of the Prostate , New Engl. J. Med. 248:86-92 ( (Jan. 15) ) 1953.Crossref 6. Ray, B. S.: Some Inferences from Hypophysectomy on 450 Human Patients , A.M.A. Arch. Neurol. 3:121-126 ( (Aug.) ) 1960.Crossref 7. Pearson, O. H., and Ray, B. S.: Hypophysectomy in the Treatment of Metastatic Mammary Cancer , Amer. J. Surg. 99:544-552 ( (April) ) 1960.Crossref 8. Cox, H. T.: Adrenalectomy and Prostatic Cancer , Lancet 2:425-426 ( (Sept. 20) ) 1947.Crossref 9. Huggins, C., and Scott, W. W.: Bilateral Adrenalectomy in Prostatic Cancer , Ann. Surg. 122:1031-1041 ( (Dec.) ) 1945.Crossref 10. MacFarlane, D. A.; Thomas, L. P., and Harrison, J. H.: A Survey of Total Adrenalectomy in Cancer of the Prostate , Amer. J. Surg. 99:562-572 ( (April) ) 1960.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Adrenalectomy for Hopeless Carcinoma of the Prostate

Archives of Surgery , Volume 84 (4) – Apr 1, 1962

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Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1962.01300220045006
Publisher site
See Article on Publisher Site

Abstract

Abstract There are only a few human malignancies which are influenced in growth and invasive behavior by hormones. Carcinomas of the breast, prostate, thyroid, and ovary are the lesions most commonly influenced, but mammary and prostatic malignancies are sometimes favorably changed when their respective hormones are abolished or nearly abolished by hypophysectomy or adrenalectomy after the respective sex organs have been removed. Growth in certain breast carcinomas is probably enhanced by an increase in estrogen, and in certain prostatic carcinomas, growth seems to accelerate by increased androgen. Observations leading to this knowledge arose after bilateral oophorectomy and bilateral orchiectomy apparently slowed the invasion of the body by these malignancies. It followed that other hormonal glands, capable of producing androgen and estrogen when the sex organs are removed, may by their hormonal activity cause the carcinoma to grow.1 When substitutive hormonal therapy was available, eradication of the adrenal gland was exploited References 1. Huggins, C., and Hodges, C. V.: Studies on Prostatic Cancer; Effect of Castration, of Estrogen, and of Androgen Injection on Serum Phosphatases in Metastatic Carcinoma of Prostate , Cancer Res. 1:293-297 ( (April) ) 1941. 2. Taylor, S. G., III; Li, M. C.; Eckles, N.; Slaughter, D. P., and McDonald, J. H.: Effect of Surgical Addison's Disease on Advanced Carcinoma of the Breast and Prostate , Cancer 6:997-1009 ( (Sept.) ) 1953.Crossref 3. West, D. D.; Hollander, V. P.; Whitmore, W. F.; Randall, H. T., and Pearson, O. H.: The Effect of Bilateral Adrenalectomy upon Neoplastic Disease in Man , Cancer 5:1009-1018 ( (Sept.) ) 1952.Crossref 4. Pyrah, L. N.: Bilateral Adrenalectomy in the Treatment of Mammary and Prostatic Cancer , Proc. Roy. Soc. Med. 47:1002-1006 ( (May 27) ) 1954. 5. Harrison, J. H.; Thorn, G. W., and Jenkins, D.: Total Adrenalectomy for Reactivated Carcinoma of the Prostate , New Engl. J. Med. 248:86-92 ( (Jan. 15) ) 1953.Crossref 6. Ray, B. S.: Some Inferences from Hypophysectomy on 450 Human Patients , A.M.A. Arch. Neurol. 3:121-126 ( (Aug.) ) 1960.Crossref 7. Pearson, O. H., and Ray, B. S.: Hypophysectomy in the Treatment of Metastatic Mammary Cancer , Amer. J. Surg. 99:544-552 ( (April) ) 1960.Crossref 8. Cox, H. T.: Adrenalectomy and Prostatic Cancer , Lancet 2:425-426 ( (Sept. 20) ) 1947.Crossref 9. Huggins, C., and Scott, W. W.: Bilateral Adrenalectomy in Prostatic Cancer , Ann. Surg. 122:1031-1041 ( (Dec.) ) 1945.Crossref 10. MacFarlane, D. A.; Thomas, L. P., and Harrison, J. H.: A Survey of Total Adrenalectomy in Cancer of the Prostate , Amer. J. Surg. 99:562-572 ( (April) ) 1960.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Apr 1, 1962

References