Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

ADRENAL CORTEX EXTRACT IN PEDIATRICS

ADRENAL CORTEX EXTRACT IN PEDIATRICS THORN1 considers and classifies acute adrenal insufficiency into three types. A fourth type of acute adrenal insufficiency, with congenital hypoplasia of adrenocortical tissue, occurs in the newborn infant.2 The respiratory signs presented by a patient with this condition were definite. There was a disappearance of moist rales, cyanosis and dyspnea after replacement therapy. Because these manifestations recurred and increased in severity with the continued withdrawal of treatment with adrenal cortex extract, it appeared that adrenocortical hormone might exert a selective action on the cardiorespiratory system. This became more probable when a review of the records of several patients who suffered from a deficiency of this hormone revealed clinical and postmortem findings of pulmonary disease.3 In addition, evidence has been presented that fatal hyalin-like membranes in the newborn might be caused by some injury to the epithelium and walls of terminal air spaces in pulmonary fields.4 We http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

ADRENAL CORTEX EXTRACT IN PEDIATRICS

Download PDF
6 pages

Loading next page...
 
/lp/american-medical-association/adrenal-cortex-extract-in-pediatrics-IUDz3ePHRy

References (7)

Publisher
American Medical Association
Copyright
Copyright © 1951 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1951.02040030333002
Publisher site
See Article on Publisher Site

Abstract

THORN1 considers and classifies acute adrenal insufficiency into three types. A fourth type of acute adrenal insufficiency, with congenital hypoplasia of adrenocortical tissue, occurs in the newborn infant.2 The respiratory signs presented by a patient with this condition were definite. There was a disappearance of moist rales, cyanosis and dyspnea after replacement therapy. Because these manifestations recurred and increased in severity with the continued withdrawal of treatment with adrenal cortex extract, it appeared that adrenocortical hormone might exert a selective action on the cardiorespiratory system. This became more probable when a review of the records of several patients who suffered from a deficiency of this hormone revealed clinical and postmortem findings of pulmonary disease.3 In addition, evidence has been presented that fatal hyalin-like membranes in the newborn might be caused by some injury to the epithelium and walls of terminal air spaces in pulmonary fields.4 We

Journal

American journal of diseases of children – American Medical Association

Published: Mar 1, 1951

There are no references for this article.