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ADJUNCTIVE THERAPY WITH DIETHYLSTILBESTROL IN OBSTETRICS AND GYNECOLOGY

ADJUNCTIVE THERAPY WITH DIETHYLSTILBESTROL IN OBSTETRICS AND GYNECOLOGY Before proceeding to evaluate the present status of diethylstilbestrol in clinical obstetrics and gynecology, let us observe where diethylstilbestrol fits into our therapeutic philosophy by briefly reviewing certain significant trends in reproductive physiology, especially as regards our conception of the so-called "sex" hormones estradiol, progesterone and testosterone. The guiding principle in these recent advances has been the premise that all biologic processes are essentially chemical in nature. Basic in its significance was the demonstration that the steroid nucleus is not essential for gynecologic activity, because its implications are so broad and sweeping. In a series of investigations that forms one of the most fascinating chapters in modern medical annals, Dodds1 and his co-workers chemically dissected the steroid skeleton of estradiol in a search for the chemical moiety requisite for gynecogenic activity. Among the scores of nonsteroidal chemical substances evolved, a very potent gynecogen was discovered in 4-4′-diethyl-dihydroxy-stilbene, popularly known http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

ADJUNCTIVE THERAPY WITH DIETHYLSTILBESTROL IN OBSTETRICS AND GYNECOLOGY

ABARBANEL, A. R.; ARANOW, HARRY; GOODFRIEND, MILTON J.
JAMA , Volume 121 (14) – Apr 3, 1943
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References (29)

Publisher
American Medical Association
Copyright
Copyright © 1943 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1943.02840140007002
Publisher site
See Article on Publisher Site

Abstract

Before proceeding to evaluate the present status of diethylstilbestrol in clinical obstetrics and gynecology, let us observe where diethylstilbestrol fits into our therapeutic philosophy by briefly reviewing certain significant trends in reproductive physiology, especially as regards our conception of the so-called "sex" hormones estradiol, progesterone and testosterone. The guiding principle in these recent advances has been the premise that all biologic processes are essentially chemical in nature. Basic in its significance was the demonstration that the steroid nucleus is not essential for gynecologic activity, because its implications are so broad and sweeping. In a series of investigations that forms one of the most fascinating chapters in modern medical annals, Dodds1 and his co-workers chemically dissected the steroid skeleton of estradiol in a search for the chemical moiety requisite for gynecogenic activity. Among the scores of nonsteroidal chemical substances evolved, a very potent gynecogen was discovered in 4-4′-diethyl-dihydroxy-stilbene, popularly known

Journal

JAMA – American Medical Association

Published: Apr 3, 1943

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