Abstract The etiology and pathogenesis of many skin diseases are obscure. Even more enigmatic is their clinical course. In some instances these dermatoses respond readily to treatment, in fact may undergo spontaneous remission. Often this is not the case. They are recalcitrant, or response is only temporary and the disease is subject to recurrences. As a result, long-term management is a frequent problem for all physicians who are concerned with dermatologic problems. Because of a frequent, absolute inability to determine the precise cause of skin conditions encountered, most dermatologists have incorporated forms of nonspecific therapy in their treatment regimen. The value of such therapy has been recognized for many years.1 Foreign proteins, pyrotherapy, vitamin therapy and administration of steroid hormones are well-known examples. Dramatic remissions of many dermatologic conditions can be produced by administration of corticotropin (ACTH) and cortisone, and these References 1. Supplied by Travenol Laboratories, Inc., Morton Grove, Ill. 2. References 7 to 16. 3. References 17 to 25. 4. O'Leary, P. A.: Present Status of Nonspecific Treatment in Dermatology , Arch. Dermat. & Syph. 5:470, 1927. 5. Nesset, N. M.; McLallen, J.; Anthony, P. Z., and Ginger, L. G.: Bacterial Pyrogens: I. Pyrogenic Preparation from a Pseudomonas Species , J. Am. Pharm. A. (Scient. Ed.) 39:456, 1950. 6. Lonson, W., and Liebert, E.: Studies on a New Pyrogen Fever Treatment , Illinois M. J. 96:: 186, 1949. 7. Page, I. H., and Taylor, R. D.: Pyrogens in the Treatment of Malignant Hypertension , J. Lab. & Clin. Med. 34:1756, 1949. 8. Kierland, R. R., and Kulwin, M. H.: Clinical Evaluation of a New Pyrogenic Agent , Arch. Dermat. & Syph. 62:571, 1950. 9. Randolph, T. G., and Rollins, J. P.: Pyromen in the Treatment of Perennial Allergic Symptoms , Ann. Allergy 8:626, 1950. 10. Wittich, F. W.: Pyromen in the Treatment of Perennial Respiratory Allergies , Ann. Allergy 9:502, 1951. 11. Leech, C. A., Jr.: Management of Hay Fever and Allergic Rhinitis with Bacterial Pyrogen , Clin. Med. 2:255, 1955. 12. Fenton, M. M.: Adjunct Treatment of Certain Allergies Responding Unsatisfactorily to Conventional Therapy , Ann. Allergy 11:336, 1953. 13. Aronoff, S., and Abolghassem, G.: Use of a Purified Non-Protein Bacterial Component, Piromen, in Allergic Conditions , J. M. Soc. New Jersey 50:564, 1953. 14. Zindler, G. A.: Pyromen Therapy in the Treatment of Food Allergy , Ann. Allergy 9:494, 1951. 15. Knight, G. F.: Experiences with Piromen in the Treatment of Allergic Disorders , Ann. Allergy 12:174, 1954. 16. Prince, H. E., and Etter, R. L.: Letters of the International Correspondence Society of Allergists, Series XVII, 1953, p. 17. 17. Samter, M., and Kofoed, M. A.: On the Rationale of Treating Allergic Diseases with Bacterial Pyrogens , J. Allergy 23:327, 1952. 18. Fond, I. A.: Piromen Therapy in Asthma , J. Allergy 24:326, 1953. 19. MacLaren, W. R., and Frank, D. E.: The Value of Piromen in the Treatment of Allergic Disorders , Ann. Allergy 11:344, 1953. 20. Welsh, A. L., and Ede, M.: An Appraisal of Piromen as a Dermatological Chemotherapeutic , Ohio M. J. , to be published. 21. Lincoln, C. S., Jr.: Clinical Aspects of Piromen Therapy in Dermatology , M. Times 83:178, 1955. 22. Howles, J. K.: Piromen Therapy in Dermatology , J. Louisiana M. Soc. 106:54, 1954. 23. McCorriston, L. R.: Piromen Treatment of Varied Dermatoses , Canad. M. A. J. 68:137, 1953. 24. Sigel, H.: Clinical Evaluation of Piromen in Dermatology , Connecticut M. J. 17:912, 1953. 25. Cobin, I.: Response of Varied Dermatoses to Piromen , Clin. Med. 61:131, 1954. 26. Guerrieri, J. A.: Treatment of Neurodermatitis with Pyromen—A New Therapeutic Agent , Clin. Med. 59:29, 1952. 27. Welsh, R. C.: Piromen Therapy in Otitis Externa, Eye, Ear , Nose and Throat Month . 32:585, 1953. 28. Oliver, R. M.: Piromen for Stubborn Dermatoses , The Schoch Letter , (March) , 1955. 29. Wexler, B. C., and others: Unpublished data, 1952-1955. 30. Soylemezoglu, B., and Wells, J. A.: Comparison of Leukocyte Response to ACTH and Bacterial Pyrogen , Proc. Soc. Exper. Biol. & Med. 77:43, 1951. 31. Windle, W. F.; Chambers, W. W.; Ricker, W. A.; Ginger, L. G., and Koenig, H.: Reaction of Tissues to Administration of Pyrogenic Preparation from a Pseudomonas Species , Am. J. M. Sc. 219:422, 1950. 32. Conn, J. W.; Fajans, S. S.; Louis, L. H.; Seltzer, H. S., and Haine, H. D.: A Comparison of Steroidal Excretion and Metabolic Effects in Man by Stress and by ACTH, in Recent Progress in Hormone Research , Vol. 10, New York, Academic Press, Inc., 1954, pp. 471-488.
A.M.A. Archives of Dermatology – American Medical Association
Published: Nov 1, 1955