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Adherence of Staphylococcus aureus to Infant Nasal Mucosal Cells

Adherence of Staphylococcus aureus to Infant Nasal Mucosal Cells Abstract Bacterial colonization in the oral cavity of humans is at a low level during the first day after birth and increases to the adult level on the third day.1.2 The reason for this lack of bacteria during early neonatal life has not been explained. The adherence capacity of groups A and B streptococci to buccal mucosal cells at birth (day 1) is minimal, but it rapidly increases to the adult level on day 3. Staphylococcus aureus varies in its ability to attach to nasal epithelial cells.3 Nasal S aureus carriers have greater affinity for S aureus than do noncarriers. The epithelial cells of the newborn may serve as a useful tool in further studies of the mechanisms involved in bacterial binding and colonization on mucosal surfaces in man. This colonization is usually requisite for subsequent clinical infection. The present study investigates the adherence of S aureus to nasal References 1. Ofek I, Beachey EH, Jefferson W, et al: Cell membrane binding properties of group A streptococcal lipoteichoic acid . J Exp Med 141:990-1003, 1975.Crossref 2. Beachey EH: Binding of group a streptococci to human oral mucosal cells by lipoteichoic acid . Assoc Am Physician Trans . 88:285-292, 1975. 3. Aly R, Shinefield HR, Strauss WG, et al: Bacterial adherence to nasal mucosal cells . Infect Immun 17:546-549, 1977. 4. Aly R, Shinefield HR, Litz C, et al: Teichoic acid in the binding of Staphylococcus aureus to nasal epithelial cells . J Infect Dis , to be published. 5. Gillespie WA, Simpson K, Tpzer RC: Staphylococcal infection in a maternity hospital . Lancet 2:1075-1080, 1958.Crossref 6. Hurst V: Transmission of hospital staphylococci among newborn infants: Colonization of the skin and mucous membranes of the infants . Pediatrics 25:204-214, 1960. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Adherence of Staphylococcus aureus to Infant Nasal Mucosal Cells

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Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1980.02130170072025
Publisher site
See Article on Publisher Site

Abstract

Abstract Bacterial colonization in the oral cavity of humans is at a low level during the first day after birth and increases to the adult level on the third day.1.2 The reason for this lack of bacteria during early neonatal life has not been explained. The adherence capacity of groups A and B streptococci to buccal mucosal cells at birth (day 1) is minimal, but it rapidly increases to the adult level on day 3. Staphylococcus aureus varies in its ability to attach to nasal epithelial cells.3 Nasal S aureus carriers have greater affinity for S aureus than do noncarriers. The epithelial cells of the newborn may serve as a useful tool in further studies of the mechanisms involved in bacterial binding and colonization on mucosal surfaces in man. This colonization is usually requisite for subsequent clinical infection. The present study investigates the adherence of S aureus to nasal References 1. Ofek I, Beachey EH, Jefferson W, et al: Cell membrane binding properties of group A streptococcal lipoteichoic acid . J Exp Med 141:990-1003, 1975.Crossref 2. Beachey EH: Binding of group a streptococci to human oral mucosal cells by lipoteichoic acid . Assoc Am Physician Trans . 88:285-292, 1975. 3. Aly R, Shinefield HR, Strauss WG, et al: Bacterial adherence to nasal mucosal cells . Infect Immun 17:546-549, 1977. 4. Aly R, Shinefield HR, Litz C, et al: Teichoic acid in the binding of Staphylococcus aureus to nasal epithelial cells . J Infect Dis , to be published. 5. Gillespie WA, Simpson K, Tpzer RC: Staphylococcal infection in a maternity hospital . Lancet 2:1075-1080, 1958.Crossref 6. Hurst V: Transmission of hospital staphylococci among newborn infants: Colonization of the skin and mucous membranes of the infants . Pediatrics 25:204-214, 1960.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: May 1, 1980

References