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ADHD Medications and Risk of Serious Cardiovascular Events in Young and Middle-aged Adults

ADHD Medications and Risk of Serious Cardiovascular Events in Young and Middle-aged Adults ORIGINAL CONTRIBUTION ONLINE FIRST Scan for Author ADHD Medications and Risk Video Interview of Serious Cardiovascular Events in Young and Middle-aged Adults Laurel A. Habel, PhD Context More than 1.5 million US adults use stimulants and other medications labeled for treatment of attention-deficit/hyperactivity disorder (ADHD). These agents can in- William O. Cooper, MD, MPH crease heart rate and blood pressure, raising concerns about their cardiovascular safety. Colin M. Sox, MD, MS Objective To examine whether current use of medications prescribed primarily to K. Arnold Chan, MD, ScD treat ADHD is associated with increased risk of serious cardiovascular events in young Bruce H. Fireman, MA and middle-aged adults. Patrick G. Arbogast, PhD Design, Setting, and Participants Retrospective, population-based cohort study using electronic health care records from 4 study sites (OptumInsight Epidemiology, T. Craig Cheetham, PharmD, MS Tennessee Medicaid, Kaiser Permanente California, and the HMO Research Net- Virginia P. Quinn, PhD, MPH work), starting in 1986 at 1 site and ending in 2005 at all sites, with additional covar- iate assessment using 2007 survey data. Participants were adults aged 25 through 64 Sascha Dublin, MD, PhD years with dispensed prescriptions for methylphenidate, amphetamine, or atomox- Denise M. Boudreau, PhD, RPh etine http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2011.1830
pmid
22161946
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION ONLINE FIRST Scan for Author ADHD Medications and Risk Video Interview of Serious Cardiovascular Events in Young and Middle-aged Adults Laurel A. Habel, PhD Context More than 1.5 million US adults use stimulants and other medications labeled for treatment of attention-deficit/hyperactivity disorder (ADHD). These agents can in- William O. Cooper, MD, MPH crease heart rate and blood pressure, raising concerns about their cardiovascular safety. Colin M. Sox, MD, MS Objective To examine whether current use of medications prescribed primarily to K. Arnold Chan, MD, ScD treat ADHD is associated with increased risk of serious cardiovascular events in young Bruce H. Fireman, MA and middle-aged adults. Patrick G. Arbogast, PhD Design, Setting, and Participants Retrospective, population-based cohort study using electronic health care records from 4 study sites (OptumInsight Epidemiology, T. Craig Cheetham, PharmD, MS Tennessee Medicaid, Kaiser Permanente California, and the HMO Research Net- Virginia P. Quinn, PhD, MPH work), starting in 1986 at 1 site and ending in 2005 at all sites, with additional covar- iate assessment using 2007 survey data. Participants were adults aged 25 through 64 Sascha Dublin, MD, PhD years with dispensed prescriptions for methylphenidate, amphetamine, or atomox- Denise M. Boudreau, PhD, RPh etine

Journal

JAMAAmerican Medical Association

Published: Dec 28, 2011

References