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W. Centerwall, S. Centerwall, V. Armon, L. Mann (1961)
Phenylketonuria. II. Results of treatment of infants and young children. A report of 10 cases.The Journal of pediatrics, 59
P. Dodge, E. Mancall, J. Crawford, J. Knapp, R. Paine (1959)
Hypoglycemia complicating treatment of phenylketonuria with a phenylalanine-deficient diet; report of two cases.The New England journal of medicine, 260 22
D.Y. Hsia (1966)
Phenylketonuria: A Study of Human Biochemical GeneticsPediatrics, 38
A. Davison, J. Dobbing (1966)
Myelination as a vulnerable period in brain development.British medical bulletin, 22 1
W.R. Centerwall (1961)
Phenylketonuria: II. Results of Treatment in Infants and Young ChildrenJ Pediat, 59
J. Benton, H. Moser, P. Dodge, S. Carr (1966)
Modification of the schedule of myelination in the rat by early nutritional deprivation.Pediatrics, 38 5
B. Sutherland, B. Umbarger, H. Berry (1966)
The treatment of phenylketonuria. A decade of results.JAMA Pediatrics, 111
S. Farber, J. Craig (1959)
CLINICAL pathological conference.Clinical proceedings - Children's Hospital of the District of Columbia, 12 6
A. Harper, P. Leung, A. Yoshida, Q. Rogers (1964)
SOME NEW THOUGHTS ON AMINO ACID IMBALANCE.Federation proceedings, 23
M. Murdoch, G. Holman (1964)
ROENTGENOLOGIC BONE CHANGES IN PHENYLKETONURIA. RELATION TO DIETARY PHENYLALANINE AND SERUM ALKALINE PHOSPHATASE.American journal of diseases of children, 107
S. Farber (1963)
Clinical Pathological ConferenceJ Pediat, 63
J. Sherman, J. Greenfield, D. Ingall (1964)
REVERSIBLE BONE-MARROW VACUOLIZATIONS IN PHENYLKETONURIA.The New England journal of medicine, 270
W. Centerwall, S. Centerwall, P. Acosta, R. Chinnock (1961)
Phenylketonuria. I. Dietary management of infants and young children.The Journal of pediatrics, 59
F. Brimblecombe, M. Stoneman (1958)
The Treatment of PhenylketonuriaJournal of the Royal Society of Medicine, 51
D. Hsia (1966)
PHENYLKETONURIA: A STUDY OF HUMAN BIOCHEMICAL GENETICS E. Mead Johnson Award Address, October 26, 1965Pediatrics, 38
J. Cravioto, B. Robles (1965)
EVOLUTION OF ADAPTIVE AND MOTOR BEHAVIOR DURING REHABILITATION FROM KWASHIORKOR.The American journal of orthopsychiatry, 35
B.S. Sutherland , B. Umbarger, H.K. and Berry (1966)
The Treatment of PhenylketonuriaAmer J Dis Child, 111
R.O. Fisch , H.J. Gravem, S.B. and Feinberg (1966)
Growth and Bone Characteristics of PhenylketonuricsAmer J Dis Child, 112
P.R. Dodge (1959)
Hypoglycemia Complicating Treatment of PhenylketonuriaNew Eng J Med, 260
Abstract AN INCREASING number of phenylketonuric infants are being fed a low-phenylalanine diet with the aim of preventing the development of mental retardation. Severe phenylalanine deprivation may result from such a diet unless the serum phenylalanine level is closely monitored and necessary adjustments of intake are promptly made. The observed lag in weight gain and linear growth1,2 in phenylketonuric infants on a low-phenylalanine diet, should not be considered a "necessary evil" or a "minor price to pay," but rather should prompt the search for a potentially correctable dietary imbalance. The consequences of amino acid imbalance on animal growth have been discussed recently by Harper et al.3 If the dietary intake of an indispensable amino acid is maintained at a suboptimal level, any further administration of an amino acid mixture with exclusion of the limiting amino acid is bound to produce more marked signs of protein deficiency, such as growth References 1. Centerwall, W.R., et al: Phenylketonuria: II. Results of Treatment in Infants and Young Children , J Pediat 59:102, 1961.Crossref 2. Fisch, R.O.; Gravem, H.J.; and Feinberg, S.B.: Growth and Bone Characteristics of Phenylketonurics , Amer J Dis Child 112:3, 1966.Crossref 3. Harper, A.E., et al: Some New Thoughts on Amino Acid Imbalance , Fed Proc 23:1087, 1964. 4. Sutherland, B.S.; Umbarger, B.; and Berry, H.K.: The Treatment of Phenylketonuria , Amer J Dis Child 111:505, 1966.Crossref 5. Sherman, J.D.; Greenfield, J.B.; and Ingall, D.: Reversible Bone Marrow Vacuolizations in Phenylketonunia , New Eng J Med 270:810, 1964.Crossref 6. Murdoch, M.D., and Holman, G.H.: Roentgenologic Bone Changes in Phenylketonuria: Relation to Dietary Phenylalanine and Serum Alkaline Phosphatase , Amer J Dis Child 107:523, 1964.Crossref 7. Dodge, P.R., et al: Hypoglycemia Complicating Treatment of Phenylketonuria , New Eng J Med 260:1104, 1959.Crossref 8. Farber, S., and Vawter, G.F.: Clinical Pathological Conference , J Pediat 63:667, 1963.Crossref 9. Hsia, D.Y.: Phenylketonuria: A Study of Human Biochemical Genetics , Pediatrics 38:173, 1966. 10. Benton, J.W., et al: Modification of the Schedule of Myelination in the Rat by Early Nutritional Deprivation , Pediatrics 38:801, 1966. 11. Davison, A.N., and Dobbing, J.: Myelination as a Vulnerable Period in Brain Development , Brit Med Bull 22:40, 1966. 12. Cravioto, J., and Robles, B.: Evolution of Adaptive and Motor Behavior During Rehabilitation From Kwashiorkor , Amer J Orthopsychiat 35:449, 1965.Crossref 13. Centerwall, W.R., et al: Phenylketonuria: I. Dietary Management of Infants and Young Children , J Pediat 59:93, 1961.Crossref
American Journal of Diseases of Children – American Medical Association
Published: May 1, 1967
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