Letters Corresponding Author: Da-Zhi Xu, MD, PhD, Department of Gastric Surgery, founders. In reality, the propensity to use REBOA is based on Sun Yat-sen University Cancer Center, 651 Dongfeng Rd E, Guangzhou 510060, baseline variables and time-dependent patient status China (email@example.com). changes from ED arrival to REBOA insertion or from ED Published Online: August 14, 2019. doi:10.1001/jamasurg.2019.2667 arrival to the completion of hemostatic procedures. Match- Conflict of Interest Disclosures: None reported. ing analyses without considering these time-dependent vari- 1. Guo J, Xu A, Sun X, et al; The SEIPLUS Randomized Clinical Trial. Combined ables created bias in determining mortality rates; the physi- surgery and extensive intraoperative peritoneal lavage vs surgery alone for ological derangement in REBOA cases might increase the treatment of locally advanced gastric cancer: the SEIPLUS randomized clinical trial [published online March 27, 2019]. JAMA Surg. doi:10.1001/jamasurg.2019. apparent mortality rate, whereas the resuscitation time bias might decrease the apparent mortality in the REBOA group. 2. Misawa K, Mochizuki Y, Ohashi N, et al. A randomized phase III trial exploring Ideally, a time-dependent propensity score–matching analy- the prognostic value of extensive intraoperative peritoneal lavage in addition to sis should be performed, with the use of sensitivity analysis standard
JAMA Surgery – American Medical Association
Published: Dec 21, 2019
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