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ADDENDUM

ADDENDUM This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract After the present paper went to press, our attention was called to the recent article by T. A. Loomis and T. C. West, Comparative Sedative Effects of a Barbiturate and Some Tranquilizer Drugs on Normal Subjects (J. Pharmacol. & Exper. Therap. 122:525-531, 1958). They found that meprobamate, chlorpromazine, and secobarbital produced a significant impairment of performance on a simulated automobile-driving apparatus. Phenaglycodol and placebo did not. Loomis and West maintained that they obtained positive results (which we, as well as other investigators, did not) because, among other things, their subjects were more thoroughly trained and their driving task was more difficult. These factors are quite possibly of real importance. Certain questions, however, may be raised about their study: 1. What is the general significance of a research in this field with only eight subjects, especially since analysis of variance showed a markedly significant difference among subjects (P<0.001) and interactions http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

ADDENDUM

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract After the present paper went to press, our attention was called to the recent article by T. A. Loomis and T. C. West, Comparative Sedative Effects of a Barbiturate and Some Tranquilizer Drugs on Normal Subjects (J. Pharmacol. & Exper. Therap. 122:525-531, 1958). They found that meprobamate, chlorpromazine, and secobarbital produced a significant...
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Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1958.02340080122026
Publisher site
See Article on Publisher Site

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract After the present paper went to press, our attention was called to the recent article by T. A. Loomis and T. C. West, Comparative Sedative Effects of a Barbiturate and Some Tranquilizer Drugs on Normal Subjects (J. Pharmacol. & Exper. Therap. 122:525-531, 1958). They found that meprobamate, chlorpromazine, and secobarbital produced a significant impairment of performance on a simulated automobile-driving apparatus. Phenaglycodol and placebo did not. Loomis and West maintained that they obtained positive results (which we, as well as other investigators, did not) because, among other things, their subjects were more thoroughly trained and their driving task was more difficult. These factors are quite possibly of real importance. Certain questions, however, may be raised about their study: 1. What is the general significance of a research in this field with only eight subjects, especially since analysis of variance showed a markedly significant difference among subjects (P<0.001) and interactions

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Aug 1, 1958

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