Abstract The clinicopathologic entity of bilateral cortical necrosis of the kidneys has been well recognized, especially since the comprehensive summary, which included 2 of the author's own cases, published by Ash1 in 1933. Many articles presenting more examples of this strange condition have appeared since then.2 In all the clinical course was characterized by one or more of the following features: absence of premonitory signs or symptoms of renal damage; acute onset of the illness (frequently subsequent to the termination of pregnancy); reduction or suppression of urinary output; elevation of systolic and diastolic blood pressures (in about one half of the cases); headache, unconsciousness and convulsions (the last occurring in about one third of the cases); vomiting and diarrhea, and a short course, terminating fatally in one to nineteen days. Coma usually preceded death. Albuminuria and the presence of erythrocytes and casts in specimens of urine examined were almost References 1. Ash, J. E.: Bilateral Cortical Necrosis of the Kidneys (Angioneurotic Anuria) , Am. J. M. Sc. 185:71, 1933.Crossref 2. Bowes, R. K.: Renal Cortical Necrosis Associated with Pregnancy , Proc. Roy. Soc. Med. 27:1505, 1934. 3. De Navasquez, S.: Histology and Pathogenesis of Bilateral Cortical Necrosis of Kidney in Pregnancy , J. Path. & Bact. 41:385, 1935. 4. Evans, N., and Gilbert, E. W.: Symmetrical Cortical Necrosis of Kidneys , Am. J. Path. 12:553, 1936. 5. Gaspar, I. A.: Bilateral Cortical Necrosis of Kidneys , Am. J. Clin. Path. 8:281,1938. 6. Garvin, C. F., and Van Wezel, N.: Bilateral Cortical Necrosis of Kidneys: Report of Case , Arch. Int. Med. 62:423 ( (Sept.) ) 1938. 7. Weaver, R. G., and von Haam, E.: Cortical Necrosis of Kidney Following Tonsillitis , Arch. Int. Med. 63: 1084 ( (June) ) 1939. 8. The abstract of the history in this case was taken from the files of the department of internal medicine. 9. Buerger, L.: Thromboangiitis Obliterans , Am. J. M. Sc. 136:567, 1908. 10. Klotz, O.: Periarteritis Nodosa , J. M. Research 37:1, 1917. 11. Goldblatt, H.: Experimental Hypertension Induced by Renal Ischemia: Harvey Lecture , Bull. New York Acad. Med. 14:523, 1938. 12. Winternitz, M. C., and others: Unpublished data.
Archives of Internal Medicine – American Medical Association
Published: Mar 1, 1941
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