This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In Reply.—I appreciate the opportunity to respond to the letter by Gallo and coworkers that was in response to our article that appeared in the January issue of the Archives. Their letter suggests that advanced head and neck cancers produce significant interleukin-6 serum levels which produce systemic responses, including acute-phase proteins as well as other secondary cytokines. In agreement with this concept, the burgeoning evidence in head and neck immunology, as well as molecular immunology, supports that tumors produce multiple secondary cytokines as well as other paracrine-secreted substances. Recent work in our laboratory has shown that squamous cell carcinoma cell lines demonstrate messenger RNA expression and secondary cytokine production of interleukin 1α and interleukin 6, as well as TGF-β. Additionally, the interaction of tumor cells, tumor-associated lymphocytes, tumor fibroblastic matrix, and other tumor microenvironment pleuripotential cells all may act in a very complex interactive manner. Such questions are being
Archives of Otolaryngology - Head & Neck Surgery – American Medical Association
Published: Dec 1, 1992
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera