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Acute-Phase Proteins and Interleukin 6 Serum Level in Head and Neck Cancer-Reply

Acute-Phase Proteins and Interleukin 6 Serum Level in Head and Neck Cancer-Reply This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In Reply.—I appreciate the opportunity to respond to the letter by Gallo and coworkers that was in response to our article that appeared in the January issue of the Archives. Their letter suggests that advanced head and neck cancers produce significant interleukin-6 serum levels which produce systemic responses, including acute-phase proteins as well as other secondary cytokines. In agreement with this concept, the burgeoning evidence in head and neck immunology, as well as molecular immunology, supports that tumors produce multiple secondary cytokines as well as other paracrine-secreted substances. Recent work in our laboratory has shown that squamous cell carcinoma cell lines demonstrate messenger RNA expression and secondary cytokine production of interleukin 1α and interleukin 6, as well as TGF-β. Additionally, the interaction of tumor cells, tumor-associated lymphocytes, tumor fibroblastic matrix, and other tumor microenvironment pleuripotential cells all may act in a very complex interactive manner. Such questions are being http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology - Head & Neck Surgery American Medical Association

Acute-Phase Proteins and Interleukin 6 Serum Level in Head and Neck Cancer-Reply

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Publisher
American Medical Association
Copyright
Copyright © 1992 American Medical Association. All Rights Reserved.
ISSN
0886-4470
eISSN
1538-361X
DOI
10.1001/archotol.1992.01880120092020
Publisher site
See Article on Publisher Site

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In Reply.—I appreciate the opportunity to respond to the letter by Gallo and coworkers that was in response to our article that appeared in the January issue of the Archives. Their letter suggests that advanced head and neck cancers produce significant interleukin-6 serum levels which produce systemic responses, including acute-phase proteins as well as other secondary cytokines. In agreement with this concept, the burgeoning evidence in head and neck immunology, as well as molecular immunology, supports that tumors produce multiple secondary cytokines as well as other paracrine-secreted substances. Recent work in our laboratory has shown that squamous cell carcinoma cell lines demonstrate messenger RNA expression and secondary cytokine production of interleukin 1α and interleukin 6, as well as TGF-β. Additionally, the interaction of tumor cells, tumor-associated lymphocytes, tumor fibroblastic matrix, and other tumor microenvironment pleuripotential cells all may act in a very complex interactive manner. Such questions are being

Journal

Archives of Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: Dec 1, 1992

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